Next generation sequencing of Epstein-Barr virus genomes in tumour tissues, saliva and blood
The objective is to discover pathogenic variants of EBV associated with particular diseases.
Clinical and molecular studies
Longitudinal follow-up of different cohorts of EBV-associated lymphoproliferative diseases in children.
Paediatric non-Hodgkin lymphoma therapeutic trials.
Using cutting-edge technologies including CNV arrays, whole exome/genome sequencing and detailed phenotypic evaluation, we identify novel variants/genes involved in the pathogenesis of human diseases.
Bioinformatics
We are interested in human genetics for both complex diseases and Mendelian disorders. We use genome-wide association studies (GWAS) to study diseases such as SLE and whole exome sequencing (WES) to reach molecular diagnoses for Mendelian disorders such as PID. We are also interested in analysis of big data in biology. For example, we try to understand susceptibility in the context of gene expression, epigenetic changes, genome biology, and immunological pathways. We also have a keen interest in improving next generation sequencing (NGS) for molecular diagnosis of Mendelian diseases and for population genetic screening. For details, see paed.hku.hk/genome
