Professor Wenwei Tu (涂文偉)
MBBS & MMSc (China), Ph.D. (HKU)
Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine,
The University of Hong Kong
Viral Immunology & Transplantation Immunology
l The 2nd class prize of “The Progress of Science & Technology”, Ministry of Education, China (2004)
l The second class prize of “The Progress of Science & Technology”, Chongqing, China (2002)
l Travel award for Federation of Clinical Immunology Societies, USA (2002)
l The third class prize of “The Progress of Science & Technology”, Chongqing, China. (1998)
l The first class prize of “The Progress of Science & Technology”, Chongqing, China (1997)
l The second class prize of “The Progress of Science & Technology”, Sichuan, China (1994)
Department of Paediatrics & Adolescent Medicine
L7-56, Labortory Block, Faculty of Medicine Building
21 Sassoon Road, Pokfulam, Hong Kong
TRANSLATIONAL IMMUNOLOGY emphasizing on discovering and translating the novel discoveries in the field of immunology to the delivery of effective immunological solutions for human diseases is my long-standing interest.
Humanized Mouse Model: My laboratory has established the humanized mice with complete human immune system. Using humanized mice, we have successfully established different disease models, such as virus infection, graft-versus-host disease (GVHD) and allograft transplantation models. Now we are focusing on establishment of different autoimmune disease models in humanized mice.
Viral Immunology: To understand cellular and molecular basis involved in the host immune responses to influenza viruses and Epstein-Barr virus (EBV) and develop novel antiviral strategies. We have report for the first time that the small-for-gestational-age and preterm neonates have impaired antiviral activity of Vγ9Vδ2-T and NK cells against influenza virus. By targeting human γδ-T cell immunity, we have further discovered novel strategies to treat human and avian influenza diseases and control EBV-induced tumors. Now we are studying the roles of γδ-T and NK cells in immune surveillance of influenza virus and EBV infections.
Transplantation Immunology: To understand the basic processes that control T-cell-mediated inflammation and tolerance. We have developed the novel methods to generate antigen-specific CD4 and CD8 regulatory T cells (Tregs). We also confirmed that ex vivo-generated human CD8 Tregs can control graft-versus-host disease (GVHD) in an allo-specific manner while leaving graft versus tumor and general immune responses intact in humanized mice. We are now focusing on translating these basic studies into the development of new therapies for GVHD, organ transplantation and autoimmune diseases.
Selected publications (* Corresponding author)
|l||Xiang Z, Liu Y, Zheng J, Liu M, Lv A, Gao Y, Hu H, Lam KT, Chan GC, Yang Y, Chen H, Tsao GS, Bonneville M, Lau YL, Tu W*. Targeted activation of human Vg9Vd2-T cells controls Epstein-Barr virus-induced B cell lymphoproliferative disease. Cancer Cell 2014 Oct 13;26(4):565-576. doi: 10.1016/j.ccr.2014.07.026. [IF: 24.755]|
|l||Wu Y, Tu W*, Lam KT, Chow KH, Ho PL, Guan Y, Peiris JS, Lau YL. Lethal co-infection of influenza virus and Streptococcus pneumoniae lowers antibody response to influenza virus in lung, and reduces germinal center B cells, T follicular helper cells and plasma cells in mediastinal lymph node. Journal of Virology. 2015 Feb;89(4):2013-23. doi: 10.1128/JVI.02455-14. [IF:5.402]|
|l||Li J, Li H, Mo H, Yu M, Feng T, Yang F, Fan Y, Lu Q, Shen C, Yin Z， Mao M, Tu W*. Impaired NK cell antiviral cytokine response against influenza virus in small-for-gestational-age neonates. Cellular and Molecular Immunology 2013 Jul 22. doi: 10.1038/cmi.2013.31. [Epub ahead of print]. M [IF: 4.185]|
|l||Li J, Li H, Mo H, Yu M, Feng T, Yang F, Fan Y, Lu Q, Shen C, Yin Z，Tu W*, Mao M. Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates. Cellular and Molecular Immunology 2013 May;10(3):253-60. M [IF: 4.185]|
|l||Qin G, Liu Y, Zheng J, Ng IH, Peiris JSM, Lau YL and Tu W*. Phenotypic and functional characterization of human γδ T cell subsets in response to influenza A viruses. Journal of Infectious Diseases. 2012;205(11):1646-53. [IF:6.410]|
|l||Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W*, and Cao X. Tyrosine kinase Btk is required for NK cell activation. Journal of Biological Chemistry. 2012;287(28):23769-78. [IF:5.328]|
|l||Liu Y, Wu Y, Lam KT, Lee PPW, Tu W* and Lau YL. Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia. Journal of Clinical Immunology2012;32(3):421-9. [IF:3.382]|
|l||Tu W*, Zheng J, Liu Y, Sia SF, Liu M, Qin G, Ng IHY, Lam KT, Peiris JSM, and Lau YL. The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice. Journal of Experimental Medicine. 2011; 208(7):1511-22. [IF:14.8]|
|l||Qin G, Liu Y, Zheng J, Ng IH, Xiang Z, Lam KT, Mao H, Li H, Peiris JSM, Lau YL and Tu W*. Type-1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses. Journal of Virology.2011; 85(19):10109-16. [IF:5.402]|
|l||Tu W*, Mao H, Zheng J, Liu Y, Chiu SS, Qin G, Chan PL, Lam KT, Guan J, Zhang L, Guan Y, Yuen KY, Peiris JSM and Lau YL. Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-react against 2009 Pandemic H1N1 Influenza Virus. Journal of Virology. 2010;84(13):6527-35. [IF:5.402]|
|l||Mao H, Tu W*, Qin G, Sia SF, Chan PL, Liu Y, Lam KT, Zheng J, Peiris JSM and Lau YL. Inhibition of human natural killer cell activity by influenza virion and hemagglutinin. Journal of Virology. 2010; 84(9):4148-57. [IF:5.402]|
|l||Mao H, Tu W*, Qin G, Law HKW, Sia SF, Chan PL, Liu Y, Lam KT, Zheng J, Peiris JSM and Lau YL. Influenza virus directly infects human natural killer cells and induces cell apoptosis. Journal of Virology. 2009;83(18):9215-22. [IF:5.402]|
|l||Qin G, Mao H, Zheng J, Sia FS, Liu Y, Peiris JSM, Lau YL and Tu W*. Phosphoantigen-expanded gammadelta T cells display potent cytotoxicity against human and avian influenza virus-infected monocyte-derived macrophages. Journal of Infectious Diseases. 2009;200(6):858-65. [IF:6.410]|
|l||Tu W, Potena L, Stepick-Biek P, Liu L, Dionis KY, Luikart H, Fearon WF, Holmes TH, Chin C, Cooke JP, Valantine HA, Mocarski ES, Lewis DB. T-Cell Immunity to Subclinical Cytomegalovirus Infection Reduces Cardiac Allograft Disease. Circulation. 2006; 114(15): 1608-15. [IF:15.202]|
|l||Zheng J, Liu Y, Liu M, Xiang Z, Lam KT, Lewis DB, Lau YL, Tu W*. Human CD8 regulatory T cells inhibit graft-versus-host disease and preserve general immunity in humanized mice. Science Translational Medicine. 2013;5(168):168ra9. [IF: 15.843]|
|l||Zheng J, Chan PL, Liu Y, Qin G, Xiang Z, Lam KT, Lewis DB, Lau YL, Tu W*. ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner. Plos One. 2013; 8(12): e82203. doi:10.1371/journal.pone.0082203. [IF:4.092]|
|l||Chan PL, Zheng J, Liu Y, Lam KT, Xiang Z, Mao H, Liu Y, Qin G, Lau YL, and Tu W*. TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells. Plos One. 2013; 8(7): e67969. doi:10.1371/journal. pone.0067969. [IF:4.092]|
|l||Zheng J, Liu Y, Qin G, Chan PL, Mao H, Lewis DB, Lau YL and Tu W*. Generation of human Th1-like regulatory CD4+ T Cells by an intrinsic IFN-g- and T-bet-dependent pathway. European Journal of Immunology. 2011;41(1):128-39. [IF:5.179]|
|l||Zheng J, Liu Y, Lau YL and Tu W*. CD40-activated B cells are more potent than immature dendritic cells to induce regulatory T cells. Cellular and Molecular Immunology. 2010, 7(1):44-50. [IF: 4.185]|
|l||Tu W*, Zheng J, Liu Y and Lau YL. Stimulatory or tolerogenic role of CD40-activated B cells depends on the strength of the activation to T cells. Blood. 2009, 114(3): 747-8. [IF: 10.896]|
|l||Zheng J, Liu Y, Qin G, Chan PL, Mao H, Lewis DB, Lau YL and Tu W*. Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells. Journal of Immunology. 2009;183(6):3742-50. [IF:6.068]|
|l||Tu W*, Lau YL, Zheng J, Liu Y, Chan PL, Mao H, Dionis K, Schneider P, and Lewis DB. Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naïve precursors by CD40-activated B cells. Blood. 2008:112(6):2554-62. [IF: 10.896]|
Research Grants & Patents
Twenty-six external peer-reviewed competitive research grants as PI or Co-PI (including RGC, AoE, TbRS, RFCID, HMRF, Croucher Foundation, NSFC, etc. total HK$ >100 millions).
Holder of 6 international research patents on cellular therapy for GVHD and allograft transplantation.
6 MPhil students (5 graduated), 10 PhD students (7 graduated), Examiners of 33 post-graduate students.