Dr Siu-yuen CHAN

BSc (HK), MPhil (HK), PhD (Cantab)


Email: sychan@hku.hk

Lab: Department of Paediatrics & Adolescent Medicine
Room L7-01, 7/F, Laboratory Block
LKS Faculty of Medicine
The University of Hong Kong
21, Sassoon Road, Pokfulam
Hong Kong


Research ID
ORCid: https://orcid.org/0000-0001-7262-1293

Developmental Biology
Molecular Biology

Research Area


Ø Molecular basis of mammalian development and genetic diseases

My research interest is in understanding the genetic control of mammalian development and how abnormalities in this process lead to diseases. Currently we are focusing on a group of nucleosome assembly proteins, the TSPYL family proteins. We aim at understanding their biological importance and identify their specific target genes. Currently, we are using CRISPR/Cas in mice and cancer cell lines.


Ø Congratulations to:

  • Huiqi Tan for receiving Scholarship for doctoral course on “Medical Development Biology” in Stockholm, Sweden, 2023;
  • Chi-ho Chong for being the 1st runner up for oral presentation in the Annual Scientific Conference of the Hong Kong Society of Neurosciences, 2016;
    Best poster award, Postgraduate Symposium, 2015
  • Anson Tsang for winning the Japanese Society of Developmental Biologists (JSDB) travel award 2010;
    Best presentation award, 43rd Annual meeting for the JSDB 2010



Team members

Priscilla Ho Shan MAK, BSc (Napier)
Vicky Huiqi TAN, BSc (STU)

Ryan Wai Hin LI, BSc (HKU)

Mia Xinfang MIAO, BSc (UCL)

Rylee Xu LUO, BSc (FJMU) MA (CQMU)


Student alumni



Recent Publications


  1. M. Cardano, M. Magni, R. Alfieri, S.Y. Chan, S. Sabbioneda, G. Buscemi & L. Zannini (2023) Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells. Cell Death & Disease, 14, 197.
  2. T.Z.E. Kang, L. Zhu, D. Yang, D. Ding, X. Zhu, Y.C.E. Wan, J. Liu, S. Ramakrishnan, L.L. Chan, S.Y. Chan, X. Wang, H. Gan, J. Han, T. Ishibashi, Q. Li, K.M. Chan (2021) The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer. J. Biol. Chem, 296, 100374.
  3. L. Peng, E.H.W. Leung, J. So, P.H.S. Mak, C.L. Lee, H. Tan, K.F. Lee and S.Y. Chan (2020) TSPYL1 regulates steroidogenic gene expression and male fertility in mice. F&S Science, doi: https://doi.org/10.1016/j.xfss.2020.08.001.
  4. C.H. Chong, Q. Li, P.H.S. Mak, C.C.P. Ng, E.H.W. Leung, V.H. Tan, A.K.W. Chan, G. McAlonan, S.Y. Chan (2019) Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation. Translational Psychiatry In press
  5. M. Mio, T. Sugiki, C. Matsuda, H. Mitsuhashi, C. Kojima, S.Y. Chan, Y.K. Hayashi, K. Mio (2019) Structural instability of lamin A tail domain modulates its assembly and higher order function in Emery-Dreifuss muscular dystrophy. Biochem Biophys Res Commun. 512(1):22-28.
  6. M. Magni, G. Buscemi, L. Maita, L. Peng, S.Y. Chan, A. Montecucco, D. Delia and L. Zannini (2018) TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage. Cell Death and Differentiation doi: 10.1038/s41418-018-0168-6.
  7. H. Liu, L. Peng, J. So, K.H. Tsang, C.H. Chong, P.H.S. Mak, K.M. Chan and S.Y. Chan (2018) TSPYL2 regulates the expression of EZH2 target genes in neurons. Molecular Neurobiology doi: 10.1007/s12035-018-1238-y.
  8. Q. Li, S.Y. Chan, K.K. Wong, R. Wei, Y.O. Leung, A.Y. Ding, T.C. Hui, C. Cheung, S.E. Chua, P.C. Sham, E.X. Wu and G.M. McAlonan. (2016) TSPYL2 loss-of-function causes neurodevelopmental brain and behaviour abnormalities in mice. Behavior Genetics 46(4), 529-37.
  9. K.H. Tsang, S.K. Lai, Q. Li, W.H. Yung, H. Liu, H.S. Mak, C.P. Ng, G. McAlonan, Y.S. Chan, S.Y. Chan (2014) The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B.
    Sci. Rep., 4, 3654.
  10. T. Eda, M. Mizuno, K. Araki, Y. Iwakura, H. Namba, H. Sotoyama, A. Kakita, H. Takahashi, H. Satoh, S.Y. Chan, H. Nawa (2013) Neurobehavioral deficits of epidermal growth factor-overexpressing transgenic mice: impact on dopamine metabolism. Neurosci. Lett., 28, 547:21-5.
  11. A.S. Don-Salu-Hewage, S.Y. Chan, K.M. McAndrews, M.A. Chetram, M.R. Dawson, D.A. Bethea, C.V. Hinton (2013) Cysteine (C)-X-C Receptor 4 Undergoes Transportin 1-Dependent Nuclear Localization and Remains Functional at the Nucleus of Metastatic Prostate Cancer Cells. PLoS One, 8(2), e57194.
  12. A.K.Y. Kwong, C.W. Fung, S.Y. Chan, V.C.N. Wong (2012) Identification of SCN1A and PCDH19 Mutations in Chinese Children with Dravet Syndrome. PLoSOne, 7(7), e41802.
  13. K.P. Tao., S.W. Fong, Z. Lu, Y. P. Ching , K.W. Chan, S.Y. Chan (2011) TSPYL2 is important for G1 checkpoint maintenance upon DNA damage. PLoS One, 6(6), e21602.
  14. Y. Liang, P.H. Chiu, K.Y. Yip, S.Y. Chan (2011) Subcellular localization of SUN2 is regulated by lamin A and rab5. PLoS One, 6(5), e20507.

Full list of publications

Departmental home page


Donation to Programme: Development and disease, Department of Paediatrics & Adolescent Medicine