Dr Siu-yuen CHAN (陳小圓)

BSc(HK), MPhil(HK), PhD(Cambridge, UK)

 

Associate Professor
Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine,
The University of Hong Kong

 

Specialty

Developmental Biology

Genetics

 

 

Contact

Email:

Tel:

Fax:
Office:

 sychan@hku.hk
(852) 22554485
(852) 28551523
Department of Paediatrics & Adolescent Medicine
Room 115, 1/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong

 

Research ID
ORCid: https://orcid.org/0000-0001-7262-1293


Publication List

  1. S.Y. Chan and M.J. Evans (1991) In situ freezing of embryonic stem cells in multi-well dishes. Trends in Genetics, 7, 76.
  2. S.Y. Chan (1991) Effects of prostaglandin E2 and F2α on peri-implantation development of mouse embryos. Prostaglandins, 42, 321-336. (Renamed as Prostaglandins, leukotrienes and essential fatty acids)
  3. S.Y. Chan, S.N. Wong and Y.L. Lau (1995) A highly informative BamHI RFLP in the type IV collagen a5 chain gene (COL4A5). Clinical Genetics, 47(5), 276-277.
  4. S.Y. Chan, S.N. Wong and Y.L. Lau (1995) A TaqI RFLP in the type IV collagen α5 chain gene (COL4A5) with the rare allele more frequently found in seven Chinese Alport syndrome patients. Clinical Genetics, 47(5), 278-279.
  5. Y.L. Lau, S.Y. Chan, M.W. Turner, J. Fong and J. Karlberg (1995) Mannose-binding protein in preterm infants: developmental profile and clinical significance. Clinical and Experimental Immunology, 102(3), 649-654.
  6. Y.L. Lau, C.S. Lau, S.Y. Chan, M.W. Turner and J. Karlberg (1996) Mannose-binding protein in Chinese with systemic lupus erythematosus. Arthritis and Rheumatism, 39, 706-708.
  7. Y.F. Hui, S.Y. Chan and Y.L. Lau (1996) Identification of mutations in seven Chinese patients with X-linked chronic granulomatous disease. Blood,88(10), 4021-4028.
  8. D.C.W. Lee, K.W. Chan and S.Y. Chan (1998) Expression of TGFα and EGF in adult polycystic kidney disease. The Journal of Urology, 159(1), 291-296.
  9. S.Y. Chan and V.C.N. Wong (1998) DNA diagnosis of FRAXA and FRAXE in Chinese children with neurodevelopmental disorders and Fragile X syndrome. Clinical Genetics, 53(3), 179-183.
  10. S.Y. Chan and D.C.W. Lee (1998) Sex difference in immunostaining of RET in the adult mouse kidney. Oncogene, 17(5), 661-666.
  11. W.K. Ip, S.Y. Chan, C.S. Lau and Y.L. Lau (1998) Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene. Arthritis and Rheumatism, 41(9), 1663-1667.
  12. R.W.P. Kwan, R.W.C. Wong, S.Y. Chan (1999) Expression of full length or truncated epidermal growth factor precursor transforms NIH3T3 fibroblasts. International Journal of Oncology, 15(2), 281-284.
  13. S.Y. Chan, Y.F. Hui and Y.L. Lau (1999) A 11-bp deletion in exon 10 (c1295del11) of WASP responsible for Wiskott-Aldrich Syndrome. Human Mutation, Mutation and Polymorphism Report #56 on line
  14. K.L. Yip, S.Y. Chan and Y.L. Lau (2000) Bruton's tyrosine kinase mutations in 8 Chinese families with X-linked agammaglobulinemia. Human Mutation, 15(4), 385
  15. W.C.S. Lau, E.W.K. Ip, C.C. Mok, Y. Ren, D. Chan, S.Y. Chan and Y.L. Lau (2000) Mannose binding lectin and autoimmune disease. A P L A R Journal of Rheumatology, 4(1), 17-21.
  16. R.W.C. Wong and S.Y. Chan (2000) Semi-quantitative immunoblots of membrane protein-epidermal growth factor. Molecular Biotechnology, 15(1), 65-67.
  17. R.W.C. Wong, M.H. Sham, Y.L. Lau and S.Y. Chan (2000) An efficient method of generating transgenic mice by pronuclear microinjection. Molecular Biotechnology, 15(2), 155-159.
  18. W.K. Ip, Y.L. Lau, S.Y. Chan, C.C. Mok, D. Chan, K.K. Tong and C.S. Lau (2000) Mannose-binding lectin and rheumatoid arthritis in Southern Chinese. Arthritis & Rheumatism, 43(8), 1679-1687.
  19. R.W.C. Wong, R.W.P. Kwan, P.H.S. Mak, K.K.L. Mak, M.H. Sham and S.Y. Chan (2000) Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice. Journal of Biological Chemistry, 275(24), 18297-18301.
  20. S.Y. Chan and R.W.C. Wong (2000) Expression of epidermal growth factor in transgenic mice causes growth retardation. Journal of Biological Chemistry, 275(49), 38693-38698.
  21. S.K. Ma, T.S.K. Wan, A.T.C. Cheuk, L.F. Fung, G.C.F. Chan, S.Y. Chan, S.Y. Ha and L.C. Chan (2001) Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study. Leukemia, 15(9), 1442-1447.
  22. R.W.C. Wong, M. Dong, K.K.L. Mak, S.Y. Chan (2001) Prospects of EGF transgenic mice researches. Acta biochimica et Biophysica Sinica, 33(5), 473-476.
  23. D.C.W. Lee, K.W. Chan, S.Y. Chan (2002) RET receptor tyrosine kinase isoforms in kidney function and disease. Oncogene, 21(36), 5582-5592.
  24. G. Sun*, S.Y. Chan*, Y. Yuan, K. W. Chan, G. Qiu, K. Sun and M. P. Leung * Equal contribution (2002) Isolation of differentially expressed genes in human heart tissues. Biochim Biophy. Acta (Section: Molecular Basis of Disease), 1588(3), 241-246. * Equal contribution
  25. K.K.L. Mak and S.Y. Chan (2003) Epidermal growth factor as a biologic switch in the hair growth cycle. Journal of Biological Chemistry, 278(28), 26120-26126.
  26. S.Y. Chan, A.K.W. Chan, B.P.K. Cheung, Y. Liang, M. P. Leung (2003) Identification of genes expressed during myocardial development. Chinese Medical Journal, 116(9), 1329-1332.
  27. R.H.K. Lee, W.L. Wong, C.H. Chan and S.Y. Chan (2006) Differential effects of glial cell line-derived neurotrophic factor and neurturin in RET/GFRα1-expressing cells. Journal of Neuroscience Research, 83(1), 80-90.
  28. Y. Liang, P. H. Chiu, K.Y. Yip and S.Y. Chan (2011) Subcellular localization of SUN2 is regulated by lamin A and rab5. PLoS One, 6(5), e20507.
  29. K. P. Tao, S. W. Fong, Z. Lu, Y. P. Ching, K. W. Chan, S.Y. Chan (2011) TSPYL2 is important for G1 checkpoint maintenance upon DNA damage. PLoS One, 6(6), e21602
  30. A.K.Y. Kwong, C.W. Fung, S.Y. Chan, V.C.N. Wong (2012) Identification of SCN1A and PCDH19 mutations in chinese children with dravet syndrome. PLoS One, 7(7), e41802.
  31. A.S. Don-Salu-Hewage, S.Y. Chan, K.M. McAndrews, M.A. Chetram, M.R. Dawson, D.A. Bethea, C.V. Hinton (2013) CXCR4 Cysteine (C)-X-C receptor 4 undergoes transportin 1-Dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoSOne, 8(2), e57194.
  32. T. Eda, M. Mizuno, K. Araki, Y. Iwakura, H. Namba, H. Sotoyama, A. Kakita, H. Takahashi, H. Satoh, S.Y. Chan, H. Nawa (2013) Neurobehavioral deficits of epidermal growth factor-overexpressing transgenic mice: impact on dopamine metabolism. Neurosciences Letter, 547, 21-25.
  33. K.H. Tsang, S.K. Lai, Q. Li, W.H. Yung, H. Liu, P.H.S. Mak, C.P. Ng, G. McAlonan, Y.S. Chan, S.Y. Chan (2014) The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B. Scientific Reports, 4, 3654.
  34. Q. Li*, S.Y. Chan*, K.K. Wong, R. Wei, Y.O. Leung, A.Y. Ding, T.C. Hui, C. Cheung, S.E. Chua, P.C. Sham, E.X. Wu, G. McAlonan (2016) TSPYL2 loss-of-function causes neurodevelopmental brain and behaviour abnormalities in mice. Behavior Genetics, 46(4), 529-537. * Equal contribution
  35. H. Liu, L. Peng, J. So, K.H. Tsang, C.H. Chong, P.H.S. Mak, K.M. Chan and S.Y. Chan (2018) TSPYL2 regulates the expression of EZH2 target genes in neurons. Molecular Neurobiology doi: 10.1007/s12035-018-1238-y.
  36. M. Magni, G. Buscemi, L. Maita, L. Peng, S.Y. Chan, A. Montecucco, D. Delia and L. Zannini (2018) TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage. Cell Death and Differentiation doi: 10.1038/s41418-018-0168-6.
  37. M. Mio, T. Sugiki, C. Matsuda, H. Mitsuhashi, C. Kojima, S.Y. Chan, Y.K. Hayashi, K. Mio (2019) Structural instability of lamin A tail domain modulates its assembly and higher order function in Emery-Dreifuss muscular dystrophy. Biochem Biophys Res Commun. 512(1), 22-28.
  38. C.H. Chong, Q. Li, P.H.S. Mak, C.C.P. Ng, E.H.W. Leung, V.H. Tan, A.K.W. Chan, G. McAlonan, S.Y. Chan (2019) Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation. Translational Psychiatry, 9(1), 244.
  39. L. Peng, E.H.W. Leung, J. So, P.H.S. Mak, C.L. Lee, H. Tan, K.F. Lee and S.Y. Chan (2020) TSPYL1 regulates steroidogenic gene expression and male fertility in mice. F&S Science, 1(2), 115-123.
  40. T.Z.E. Kang, L. Zhu, D. Yang, D. Ding, X. Zhu, Y.C.E. Wan, J. Liu, S. Ramakrishnan, L.L. Chan, S.Y. Chan, X. Wang, H. Gan, J. Han, T. Ishibashi, Q. Li, K.M. Chan (2021) The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer. Journal of Biological Chemistry, 296, 100374.
  41. K.W. Chan, C.Y.A. Wong, D. Leung, X. Yang, S.F.S. Fok, H.S. Mak, Y. Lei, W. Ma, H. Mao, X. Zhao, W. Liang, S. Singh, M.R. Barbouche, J.X. He, L. P. Jiang, W.K. Liew, M.H.T. Le, D. Muktiarti, F.H. Santos-Ocamo, R. Djidjik, B. Belaid, I.H. Ismail, A.H. Abdul Latiff, W.S. Lee, T.X. Chen, J. Liu, R. Jin, X. Wang, Y.H. Chen, H.H. Yu, D. Raj, R. Raj, J. Vaughan, M. Urban, S. van den Berg, B. Eley, A.C. W. Lee, M.S. Isa, E.Y. Ang, B.W. Lee, A.E.J. Yeoh, L.P. Shek, N.N. Quynh Le, V.A.T. Nguyen, A. Phan Nguyen Lien, R.D. Capulong, J.M. Mallillin, J.C.M.M. Villanueva, K.A.B. Camonayan, M. De Vera, R.J. Casis-Hao, R.C.M. Lobo, R. Foronda, V.W.E. Binas, S. Boushaki, N. Kechout, G. Phongsamart, S. Wongwaree, C. Jiratchaya, M. Lao-Araya, M. Trakultivakorn, N. Suratannon, O. Jirapongsananuruk, T. Chantveerawong, W. Kamchaisatian, L.L. Chan, M.T. Koh, K.J. Wong, S.M. Fong, M.K. Thong, A.Z. Latiff, L.M. Noh, R. de Silva, Z. Jouhadi, K. Al-Saad, P. Vignesh, A.K. Jindal, A. Rawat, A. Gupta, D. Suri, J. Yang, E.Y.L. Au, J.S.Y. Kwok, S.Y. Chan, W.Y.F. Hui, G.T. Chua, J. Sou Da Rosa Duque, K.N. Cheong, C.Y. Chong, M.H.K. Ho, T.L. Lee, W.H.S. Wong, W. Yang, P.P.W. Lee, W. Tu, X.Q. Yang, Y.L. Lau (2022) Targeted gene sanger sequencing should remain the first-tier genetic test for children suspected to have the five common X-linked inborn errors of immunity. Frontiers in Immunology, 13,883446. doi: 10.3389/fimmu.2022.883446. eCollection 2022.
  42. M. Cardano, M. Magni, R. Alfieri, S.Y. Chan, S. Sabbioneda, G. Buscemi & L. Zannini (2023) Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells. Cell Death & Disease, 14, 197.
  43. H. Tan, M.X. Miao, R.X. Luo, J. So, L. Peng, X. Zhu, E.H. W. Leung, L. Zhu, K.M. Chan, M. Cheung*, S. Y. Chan* (2024) TSPYL1 as a Critical Regulator of TGFβ signaling through Repression of TGFΒR1 and TSPYL2. Advanced Science. 2024 Apr 8:e2306486. doi: 10.1002/advs.202306486. Online ahead of print.

 

 

 

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