Professor Wing Hang LEUNG (梁永恆)

MBBS(HK), PhD(Johns Hopkins)

Clinical Professor

Department of Paediatrics and Adolescent Medicine

School of Clinical Medicine

Jiaohua Su Professor in Paediatric Oncology and Transplant

The University of Hong Kong



Specialist in Paediatrics

Diplomate, American Board of Pediatrics

Board Certified in Pediatric Hematology-Oncology by the American Board of Pediatrics



American Society of Clinical Oncology (ASCO) Young Investigator Award
Phi Beta Kappa – Johns Hopkins University

Elected and inducted into the American Society for Clinical Investigation







(852) 2255-4090
(852) 2855-1523
Department of Paediatrics & Adolescent Medicine
Room 117, 1/F, New Clinical Building,

Queen Mary Hospital, 102 Pokfulam Road,
Hong Kong


Research ID

ORCid :



h-index: 60


Research areas

Prof Leung’s research work focuses on the followings:


(a) Cell therapy for cancer and infectious diseases:

• Chimeric antigen receptor modified T cells and NK cells (CAR-T and CAR-NK)

• Graft-versus-malignancy and graft engineering

• Virus-specific T cells and memory T cells

(b) Paediatric immunome:

• Cancer immunome

• Immnunogenomics

• Biological determinants of oncoimmunology effect


Selected publications

  1. Wang T, Tang Y, Cai J, Wan X, Hu S, Lu X, Xie Z, Qiao X, Jiang H, Shao J, Yang F, Ren H, Cao Q, Qian J, Zhang J, An K, Wang J, Luo C, Liang H, Miao Y, Ma Y, Wang X, Ding L, Song L, He H, Shi W, Xiao P, Yang X, Yang J, Li W, Zhu Y, Wang N, Gu L, Chen Q, Tang J, Yang JJ, Cheng C, Leung W†, Chen J†, Lu J†, Li B†, Pui CH†. Coadministration of CD19- and CD22-Directed Chimeric Antigen Receptor T-Cell Therapy in Childhood B-Cell Acute Lymphoblastic Leukemia: A Single-Arm, Multicenter, Phase II Trial. J Clin Oncol. JCO2201214, 2022. PMID: 36346962 († contributed equally)
  2. Pulsipher MA, Ahn KW, Bunin NJ, Lalefar NR, Anderson EJ, Flower A, Cairo MS, Talano JA, Chaudhury S, Kitko CL, Duke JL, Monos D, Leung W, Dvorak CC, Abdel-Azim H. KIR-Favorable TCR-αβ/CD19-Depleted Haploidentical HCT in Children with ALL/AML/MDS: Primary Analysis of PTCTC ONC1401. Blood. 140(24):2556-2572, 2022. PMID: 35776909.
  3. Furman WL, McCarville B, Shulkin BL, Davidoff A, Krasin M, Hsu CW, Pan H, Wu J, Brennan R, Bishop MW, Helmig S, Stewart E, Navid F, Triplett B, Santana V, Santiago T, Hank JA, Gillies SD, Yu A, Sondel PM, Leung WH, Pappo A, Federico SM. Improved Outcome in Children With Newly Diagnosed High-Risk Neuroblastoma Treated With Chemoimmunotherapy: Updated Results of a Phase II Study Using hu14.18K322A. J Clin Oncol. 40(4):335-344, 2022.
  4. Qayed M, Ahn KW, Kitko CL, Johnson MH, Shah NN, Dvorak CC, Mellgren KM, Friend BD, Verneris MR, Leung W, Toporski J, Levine JE, Chewning JH, Wayne AS, Kapoor U, Triplett BM, Schultz KR, Yanik GA, Eapen M. A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation. Blood. 137(7):983-993, 2021 [PMCID: PMC7918183]
  5. Nguyen R, Sahr N, Sykes A, McCarville MB, Federico SM, Sooter A, Cullins D, Rooney B, Janssen WE, Talleur AC, Triplett BM, Anthony G, Dyer MA, Pappo AS, Leung W, Furman WL. Longitudinal NK Cell Kinetics and Cytotoxicity in Children With Neuroblastoma Enrolled in a Clinical Phase II Trial. J Immunother Cancer. 8(1):e000176, 2020. [PMCID: PMC7206969]
  6. Bari R, Granzin M, Tsang KS, Roy A, Krueger W, Orentas R, Pfeifer R, Moeker N, Verhoeyen E, Dropulic B, Leung W. A Distinct Subset of Highly Proliferative and Lentiviral Vector (LV)-Transducible NK Cells Define a Readily Engineered Subset for Adoptive Cellular Therapy. Front Immunol. 10:2001, 2019. [PMCID: PMC6713925].
  7. Fernández L, Metais JY, Escudero A, Vela M, Valentín J, Vallcorba I, Leivas A, Torres J, Valeri A, Patiño-García A, Martínez J, Leung W, Pérez-Martínez A. Memory T cells expressing an NKG2D-CAR efficiently target osteosarcoma cells. Clin Cancer Res. 23(19):5824-5835, 2017
  8. Chan WK, Suwannasaen D, Throm RE, Li Y, Eldridge PW, Houston J, Gray JT, Pui CH, Leung W. Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity. Leukemia. 29(2):387-95, 2015 [PMCID:PMC4275423]
  9. Pui CH, Pei D, Coustan-Smith E, Jeha S, Cheng C, Bowman WP, Sandlund JT, Ribeiro RC, Rubnitz JE, Inaba H, Bhojwani D, Gruber TA, Leung W, Downing JR, Evans WE, Relling MV, Campana D. Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study. Lancet Oncol. 16(4):465-74, 2015
  10. Vong QP, Leung WH, Houston J, Li Y, Rooney B, Holladay M, Oostendorp R, Leung W. TOX2 regulates human natural killer cell development by controlling T-BET expression. Blood. 124(26):3905-13, 2014 [PMCID:PMC4282154]
  11. Willard VW, Leung W, Huang Q, Zhang H, Phipps S. Cognitive outcome after pediatric stem-cell transplantation: impact of age and total-body irradiation. J Clin Oncol. 32(35):3982-8, 2014. [PMCID:PMC4251961]
  12. Leung WH, Vong QP, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation. J Exp Med. 210:2675-2692, 2013. [PMCID: PMC3832934]
  13. Bari R, Rujkijyanont P, Sullivan E, Kang G, Turner V, Gan K, Leung W. Effect of Donor KIR2DL1 Allelic Polymorphism on the Outcome of Pediatric Allogeneic Hematopoietic Stem-Cell Transplantation. J Clin Oncol. 31(30):3782-90, 2013. [PMCID: PMC3795888].
  14. Leung W, Pui CH, Coustan-Smith E, Yang J, Pei D, Gan K, Rubnitz JE, Sandlund JT, Ribeiro RC, Srinivasan A, Hartford C, Triplett BM, Dallas M, Pillai A, Handgretinger R, Laver JH, Campana D. Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia. Blood.  120(2):468-472, 2012 [PMCID: PMC3398757]
  15. Inaba H, Yang J, Kaste SC, Hartford CM, Motosue MS, Chemaitilly W, Triplett BM, Shook DR, Pui CH, Leung W. Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation. J Clin Oncol. 30(32):3991-7, 2012. [PMCID: PMC3675688].
  16. Leung W, Campana D, Yang J, Pei D, Coustan-Smith E, Gan K, Rubnitz JE, Sandlund JT, Ribeiro RC, Srinivasan A, Hartford C, Triplett BM, Dallas M, Pillai A, Handgretinger R, Laver JH, Pui CH. High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia. Blood. 118(2):223-30, 2011 [PMCID: PMC3138677]
  17. Rubnitz JE, Inaba H, Ribeiro RC, Pounds S, Rooney B, Bell T, Pui CH, Leung W. NKAML: A pilot study of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol. 28(6):955-9, 2010 [PMCID: PMC2834435]
  18. Rubnitz JE, Inaba H, Dahl G, Ribeiro RC, Bowman WP, Taub J, Pounds S, Razzouk BI, Lacayo NJ, Cao X, Meshinchi S, Degar B, Airewele G, Raimondi SC, Onciu M, Coustan-Smith E, Downing JR, Leung W, Pui CH, Campana D. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial. Lancet Oncol. 11(6):543-52, 2010 [PMCID: PMC3171799]
  19. Bari R, Bell T, Leung WH, Vong QP, Chan WK, Dasgupta N, Holladay M, Rooney B, Leung W. Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine245. Blood 114(25):5182-90, 2009 [PMCID: PMC2792213]
  20. Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles A, Metzger ML, Boyett JM, Leung W, Handgretinger R, Downing JR, Evans WE, Relling MV. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 360(26):2730-41, 2009 [PMCID: PMC2754320]
  21. Phipps S, Rai SN, Leung W, Lensing S, Dunavant M. Cognitive and academic consequences of stem-cell transplantation in children. J Clin Oncol. 26(12):2027-2033, 2008.
  22. Leung W, Iyengar R, Turner V, Lang P, Bader P, Conn P, Niethamer D, Handgretinger R. Determinants of antileukemia effects of allogeneic NK cells. J Immunol. 172(1):644-650, 2004.
  23. Pui CH, Cheng C, Leung W, Rai SN, Rivera GK, Sandlund JT, Relling MV, Kun LE, Evans WE, Hudson MM. Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. N Eng J Med. 349(7):640-9, 2003
  24. Leung W, Rose SR, Zhou Y, Hancock ML, Burstein S, Schriock EA, Lustig R, Danish RK, Evans WE, Hudson MM, Pui CH. Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 20(13):2959-2964, 2002
  25. Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH.  Late effects of treatment in survivors of childhood acute myeloid leukemia.  J Clin Oncol. 18:3273-3279, 2000.

Full publication list





>30 Graduate students and postdoctoral fellows



Clinical Service


Hematopoietic cell transplantation and cellular therapy