Dr. Chan Hoi Shan Sophelia (陳凱珊)

MBBS(HK), MRCP(UK), MMedSc(HK), FHKAM(Paed), FHKCPaed, MD(HK)

 

Clinical Associate Professor

Honorary Consultant

Division of Neurology, Developmental Paediatrics & Neurohabilitation

Department of Paediatrics and Adolescent Medicine,
School of Clinical Medicine,

The University of Hong Kong

 

Specialty

Paediatric Neurology

Developmental Behavioural Paediatrics

 

Contact

Tel:

Fax:

Email:

Office:

 (852) 22554090
(852) 22554089
sophehs@hku.hk
Department of Paediatrics & Adolescent Medicine
Room 115, 1/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong

 

Full list of Publications / Conference Papers / Book Chapters

 

PUBLICATIONS IN PEER-REVIEWED JOURNALS

  1. Treatment of symptomatic spinal muscular atrophy with nusinersen: a prospective longitudinal study on scoliosis progression. HNH Ip, MKL Yu, WHS Wong, A Liu, Kenny YH Kwan*, SHS Chan*. Journal of Neuromuscular Diseases. Neuromuscul Dis. Published online February 15, 2024. doi:10.3233/JND-230077
  2. Bone health status of children with spinal muscular atrophy. Joanna YL Tung, TK Chow, M Wai, J Lo, SHS Chan. J Bone Metab 2023;30(4):319-327. https://doi.org/10.11005/jbm.2023.30.4.319
  3. A pilot study of an integrated, personalized, respiratory and motor telerehabilitation program for pediatric patients with hereditary neuromuscular disorders. Yu MKL, Chiu AYY, Chau SK, Rosa Duque JS, Wong WHS, Chan SHS*. Muscle Nerve. 2023 Nov;68(6):857-864. doi: 10.1002/mus.27982.
  4. Hesitancy, reactogenicity, and immunogenicity of the mRNA and whole-virus inactivated covid-19 vaccines in pediatric neuromuscular diseases. MKL Yu, SHS Chan, S Cheng, D Leung, SM Chan, ASK Yan, WHS Wong, M Peiris, YL Lau, JSR Duque. Human Vaccines & Immunotherapeutics. 2023 May 9:2206278. doi: 10.1080/21645515.2023.2206278.
  5. CHKB-Related Muscular Dystrophy. Chan SHS, & Nishino I. (2023). CHKB-Related Muscular Dystrophy. 2023 Mar 30. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023.
  6. Collagen VI-related myopathies: clinical variability, phenotype-genotype correlation and exploratory transcriptome study. Kwong AK, Zhang Y, Ho RS, Gao Y, Ling X, Tsang MH, Luk HM, Chung BH, Bönnemann CG, Javed A*, Chan SH*. Neuromuscular Disorders. 2023 Mar 12;33(5):371-381. doi: 10.1016/j.nmd.2023.03.003. Epub ahead of print.
  7. The role of the gut-microbiome-brain-axis in metabolic remodeling amongst children with cerebral palsy and epilepsy.Peng Y, Chiu ATG, Li VWY, Zhang X, Yeung WL, Chan SHS*, Tun HM*. Frontiers in Neurology. 2023 Feb 27;14:1109469. doi: 10.3389/fneur.2023.1109469.
  8. Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections. Tso WWY, Kwan MYW, Wang YL, Leung LK, Leung D, Chua GT, Ip P, Fong DYT, Wong WHS, Chan SHS, Chan JFW, Peiris M, Lau YL, Rosa Duque JS. Emerging Microbes & Infections. 2022 Dec;11(1):1742-1750.
  9. Significant healthcare burden and life cost of spinal muscular atrophy: real-world data. Chan, SHS#*, Wong, CKH*, Wu T, Wong W, Yu MKL, Au ICH, & Chan GCF. The European Journal of Health Economics. 2022 Nov 20.doi: 10.1007/s10198-022-01548-5. https://doi-org.eproxy.lib.hku.hk/10.1007/ s10198-022-01548-5
    [https://smanewstoday.com/news/costs-sma-extremely-high-prior-disease-modifying-treatment/]
  10. Mental health & maltreatment risk of children with special educational needs during COVID-19. Tso WWY, Chan KL, Lee TMC, Rao N, Lee SL, Jiang F, Chan SHS, Wong WHS, Wong RS, Tung KTS, Yam JC, Liu APY, Chua GT, Rosa Duque JS, Lam ALN, Yip KM, Leung LK, Wang Y, Sun J, Wang G, Chan GCF, Wong ICK, Ip P*. Child Abuse and Neglect. 2022 Aug;130(Pt 1):105457. doi: 10.1016/j.chiabu.2021.105457.
  11. Guillain-Barré syndrome in children - High occurrence of Miller Fisher syndrome in East Asian region. Chiu ATG, Chan RWK, Yau MLY, Yuen ACL, Lam AKF, Lau SWY, Lau AMC, Fung STH, Ma KH, Lau CWL, Yau MM, Ko CH, Tsui KW, Ma CK, Tai SM, Yau EKC, Fung E, Wu SP, Kwong KL, Chan SHS*. Brain and Development. 2022 Jul 26:S0387-7604(22)00116-4. doi: 10.1016/j.braindev.2022.07.003.
  12. Clinical spectrum and burden of influenza-associated neurological complications in hospitalised paediatric patients. Yu MKL, Leung CPP, Wong WHS, Ho ACC,Chiu ATG, Zhi HH, Chan GCF, Chan SHS*. Frontiers in Pediatrics. 2022 Jan 20;9:752816. doi: 10.3389/fped.2021.752816.
  13. Infantile to late adulthood onset facioscapulohumeral dystrophy type 1: a case series Hong Kong. Leung WY, Luk HM, Vardhanabhuti V, Hui KF,Lau WY, Young TPH, Li JTC, Fung ELW, Chiu ATG, Lo IFM, Chung BHY, Cheung YF, Chan SHS* . Hong Kong Medical Journal. 2021 Dec;27(6):444-449. doi: 10.12809/hkmj209001.
  14. Nusinersen in spinal muscular atrophy type 1 from neonates to young adult: 1-year data from three Asia-Pacific regions. Chan SH#*, Chae JH, Chien YH, Ko TS, Lee JH, Lee YJ, Nam SO, Jong YJ*. Journal of Neurology, Neurosurgery and Psychiatry. 2021 Nov;92(11):1244-1246. doi: 10.1136/jnnp- 2020-324532.
  15. Changes in pediatric seizure-related emergency department attendances during COVID-19 - A territory-wide observational study. Chiu TGA, Leung WCY, Zhang Q, Lau EHY, Ho RW, Chan HS, Chang RS*. Journal of the Formosan Medical Association. 2021 Aug;120(8):1647-1651. doi: 10.1016/j.jfma.2020.11.006.
  16. Prevalence and healthcare utilization of rare neurological diseases in HK: 2014-2018. Chiu ATG, Li J, Chang RSK, Chung CCY, Wong WHS, Ip P, Chan SHS* European Journal of Neurology. 2021 Jul;28(7):2305-2312. doi: 10.1111/ene.14852.
  17. Newborn screening programs for spinal muscular atrophy worldwide: Where we stand and where to go. Dangouloff T, Vrščaj E, Servais L, Osredkar D; SMA NBS World  Study Group. Neuromuscular Disorders. 2021 Apr 7:S0960-8966(21)00071-7. doi: 10.1016/j.nmd.2021.03.007.
  18. Intrathecal Baclofen pump infection with meningitis: effective treatment by radical debridement and intrareservoir baclofen-vancomycin co-infusion. Koljonen PA*, Chan SHS, Liu T, Ho ACC, Chim S, Tsoi NS, Wong YW. Neuromodulation. 2021 Feb 3. doi: 10.1111/ner.13369.
  19. Bone microarchitectural alterations in boys with Duchenne muscular dystrophy on long- term glucocorticoid treatment. Tung JY*, Lam TP, Chan SHS. Journal of Bone and Mineral Metabolism. 2021 Jan 5: doi: 10.1007/s00774-020-01196-w.
  20. The impact of Paediatric neuromuscular disorders on parents’ health-related quality of life and family functioning. MHT Ho, R Liang, YT Ip, H Zhi, WHS Wong, SHS Chan*. HK J Paediatr 2021;26(1): 2020.
  21. Deep learning-based thigh muscle segmentation for reproducible fat fraction quantification using fat-water decomposition MRI. Ding J, Cao P, Chang HC, Gao Y, Chan SHS, Vardhanabhuti V*.Insights Into Imaging. 2020 Nov 30;11(1):128. doi: 10.1186/s13244-020-00946-8.
  22. Neurogenetic fetal akinesia and arthrogryposis: genetics, expanding genotype-phenotypes and functional genomics. Ravenscroft G, Clayton JS, Faiz F, Sivadorai P, Milnes D, Cincotta R,Moon P, Kamien B, Edwards M,Delatycki M, Lamont PJ, Chan SHs, Colley A, Ma A, Collins F, Hennington L, Zhao T,McGillivray G, Ghedia S,Chao K, O'Donnell-Luria A, Laing NG,Davis MR. Journal of Medical Genetics. 2020 Oct 15:jmedgenet-2020-106901.doi:10.1136/jmedgenet-2020-106901.
  23. Generation of genomic-integration-free human induced pluripotent stem cells and the derived cardiomyocytes of X-linked dilated cardiomyopathy from DMD gene mutation. Zhu S, Law AHY, Deng R, Poon ENY, Lo CW, Kwong AKY, Liang R, Chan KYK, Wong WL, Tan-Un KC, Pijnappel WWMP, Chan GCF*, Chan SHS*. Stem Cell Research. 2020 Oct 12;49:102040. doi: 10.1016/j.scr.2020.102040.
  24. A case report of complement C4B deficiency in a patient with steroid and IVIG-refractory anti-NMDA receptor encephalitis. Chua GT, Zhou D, Ho ACC, Chan SHS, Yu CY, Lau YL. BMC Neurology. 2020 Sep 8;20(1):339. doi: 10.1186/s12883-020-01906-x.
  25. Clinical spectrum and genetic variations of LMNA-related muscular dystrophies in a large cohort of Chinese patients. Fan Y, Tan D, Song D, Zhang X, Chang X, Wang Z, Zhang C, Chan SH, Wu Q, Wu L, Wang S, Yan H, Ge L, Yang H, Mao B, Bönnemann C, Liu J, Wang S, Yuan Y, Wu X, Zhang H, Xiong H. Journal of Medical Genetics. 2020 Jun 22;jmedgenet-2019-106671.doi: 10.1136/jmedgenet-2019-106671
  26. The KLHL40 c.1516A>C is a Chinese-specific founder mutation causing nemaline myopathy 8: Report of six patients with pre-and-postnatal phenotypes. Yeung KS, Yu FNY, Fung CW, Wong S, Lee HCH, Fung STH, Fung GPG, Leung KY, Chung WH, Lee YT, Ng VKS, Yu MHC, Fung JLF, Tsang MHY, Chan KYK, Chan SHS*, Kan ASY*, Chung BHY*. Molecular Genetics and Genomic Medicine. 2020 Apr 30:e1229. doi: 10.1002/mgg3.1229.
  27. Clinical practice with steroid therapy for Duchenne muscular dystrophy: An expert survey in Asia and Oceania. Takeuchi F, Nakamura H, Yonemoto N, Komaki H, Rosales RL, Kornberg AJ, Bretag AH, Dejthevaporn C, Goh KJ, Jong YJ, Kim DS, Khadilkar SV, Shen D, Wong KT, Chai J, Chan SH, Khan S, Ohnmar O, Nishino I, Takeda S, Nonaka I*. Brain and Development. 2020 Mar;42(3):277-288. doi: 10.1016/j.braindev.2019.12.005.
  28. Diagnostic value of whole-exome sequencing in Chinese pediatric-onset neuromuscular patients. Tsang MHY, Chiu ATG, Kwong BMH, Liang R, Yu MHC, Yeung KS, Ho WHL, Mak CCY, Leung GKC, Pei SLC, Fung JLF, Wong VCN, Muntoni F, Chung BHY*, Chan SHS*. Molecular Genetics and Genomic Medicine. 2020 Mar 10:e1205. doi: 10.1002/mgg3.1205.
  29. Megaconial congenital muscular dystrophy: Same novel homozygous mutation in CHKB gene in two unrelated Chinese patients. Chan SH#*, Ho RS, Khong PL, Chung BH, Tsang MH, Yu MH, Yeung MC, Chan AO, Fung CW. Neuromuscular Disorders. 2020 Jan;30(1):47-53. doi: 10.1016/j.nmd.2019.10.009.
  30. 神经肌肉病患儿新型冠状病毒病疫情期间防控及管理建议
    中华医学会儿科分会内分泌遗传代谢学组、神经学组、康复学组全体委员（按姓氏汉语拼音排序）；常杏芝（北京大学第一医院儿科）；陈凯珊（香港大学玛丽医院儿童脑神经科）；李西华（复旦大学附属儿科医院神经内科）；罗小平（华中科技大学同济医学院附属同济医院儿科学系）；吕俊兰（北京儿童医院神经内科）；马祎楠（北京大学第一医院产前诊断中心）；秦炯（北京大学人民医院儿科）；阙呈立（北京大学第一医院呼吸内科）；沈定国（解放军总医院神经内科）；宋昉（首都儿科研究所遗传研究室）；王朝霞（北京大学第一医院神经内科）；王家勤（新乡医学院第三附属医院儿科）；许志飞（北京儿童医院呼吸 科）；袁云（北京大学第一医院神经内科）；邹丽萍（解放军总医院儿科）. 中华实用儿科临床杂志，2020，35(2)：125-129.DOI: 10.3760/cma.j.issn.2095- 428X.2020.02.008.
  31. MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement. Donkervoort S, Sabouny R, Yun P, Gauquelin L, Chao KR, Hu Y, Al Khatib I, Töpf A, Mohassel P, Cummings BB, Kaur R, Saade D, Moore SA, Waddell LB, Farrar MA, Goodrich JK, Uapinyoying P, Chan SHS, Javed A, Leach ME, Karachunski P, Dalton J, Medne L, Harper A, Thompson C, Thiffault I, Specht S, Lamont RE, Saunders C, Racher H, Bernier FP, Mowat D, Witting N, Vissing J, Hanson R, Coffman KA, Hainlen M, Parboosingh JS, Carnevale A, Yoon G, Schnur RE, Care4Rare Canada Consortium, Boycott KM, Mah JK, Straub V, Foley AR, Innes AM, Bönnemann CG*, Shutt TE*. Acta Neuropathologica. 2019 Dec;138(6):1013-1031. doi: 10.1007/s00401-019-02059-z.
  32. Health-related quality of life in Chinese boys with Duchenne muscular dystrophy and their families. Liang R, Chan SHS*, Ho FKW, Tang OC, Cherk SWW, Ip P, Lau EYY. J Child Health Care. 2019 Sep;23(3):495-506. doi: 10.1177/1367493519857423.
  33. Congenital muscular dystrophy in China. Ge L, Zhang C, Wang Z, Chan SHS, Zhu W, Zhang X, Zheng H, Wu L, Jin B, Shan J, Mao B, Zhong J, Peng X, Cheng Y, Hu J, Sun Y, Lu J, Hua Y, Zhu S, Wei C, Wang S, Jiao H, Yang H, Fu X, Fan Y, Chang X, Wang S, Bao X, Zhang Y, Wang J, Wu Y, Jiang Y, Yuan Y, Rutkowski A, Bönnemann CG, Wei W, Wu X, Xiong H*. Clinical Genetics. 2019 Sep;96(3):207-215. doi: 10.1111/cge.13560.
  34. A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35. Fung JLF, Tsang MHY, Leung GKC, Yeung KS, Mak CCY, Fung CW, Chan SHS, Yu MHC, Chung BHY*. Parkinsonism and Related Disorders. 2019 Jun;63:42-45. doi: 10.1016/j.parkreldis.2019.01.013.
  35. Knowledge, attitude and ethical consideration of Chinese couples requesting preimplantation genetic testing in Hong Kong. Chan SHS*, Li RHW, Lee VCY, Tang MHY, Ng EHY. Journal of Obstetrtics and Gynaecology Research. 2019 Feb 11. doi: 10.1111/jog.13940.
  36. Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors. Tso WWY#, Liu APY#, Lee TMC, Cheuk KL, Shing MK, Luk CW, Ling SC, Ku DTL, Li K, Yung AWY, Fung CW, Chan SHS, Ho ACC, Ho FKW, Ip P*, Chan GCF*. Journal of  Neuro-oncology. 2019 Jan;141(2):393-401. doi: 10.1007/s11060-018-03045-3.
  37. Panel-based exome sequencing for neuromuscular disorders as a diagnostic service. Westra D, Schouten MI, Stunnenberg BC, Kusters B, Saris CGJ, Erasmus CE, van Engelen BG, Bulk S, Verschuuren-Bemelmans CC, Gerkes EH, de Geus C, van der Zwaag PA, Chan S, Chung B, Barge-Schaapveld DQCM, Kriek M, Sznajer Y, van Spaendonck-Zwarts K, van der Kooi AJ, Krause A, Schönewolf-Greulich B, de Die-Smulders C, Sallevelt SCEH, Krapels IPC, Rasmussen M, Maystadt I, Kievit AJA, Witting N, Pennings M, Meijer R, Gillissen C, Kamsteeg EJ, Voermans NC*. Journal of Neuromuscul Diseases. 2019;6(2):241-258. doi: 10.3233/JND-180376.
  38. 脊髓性肌萎缩症多学科管理专家共识 中华医学会儿科分会神经学, 专家委员会成员（按姓氏拼音排列）：曹玲；陈凯珊；陈万金；戴毅；葛琳；洪思琦；黄真；李淳德；李海峰；李西华；梁芙蓉；吕俊兰；马祎楠; 彭晓音；秦炯；瞿宇晋；阙呈立；沈定国；宋昉；王朝霞；魏翠洁；吴丽文；吴士文；熊晖；许志飞；张成. 中华医学杂志 2019,99(19):1460-1467; https://rs.yiigle.com/CN112137201919/1147872.htm
  39. A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality. Chan SHS#*, van Alfen N, Thuestad IJ, Ip J, Chan AO, Mak C, Chung BH, Verrips A, Kamsteeg EJ. Neuromuscular Disorders. 2018 Sep;28(9):750-756. doi: 10.1016/j.nmd.2018.07.002.
  40. Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey. Mak CC, Leung GK, Mok GT, Yeung KS, Yang W, Fung CW, Chan SH, Lee SL, Lee NC, Pfundt R, Lau YL, Chung BH*. NPJ Genomic Medicine. 2018 Aug 6;3:19. doi: 10.1038/s41525-018-0056-5.
  41. Anti-N-methyl-d-aspartate receptor encephalitis in children: Incidence and experience in Hong Kong. Ho AC, Chan SH*, Chan E, Wong SS, Fung ST, Cherk SW, Fung EL, Ma KH, Tsui KW, Yau EK, Wong VC. Brain and Development. 2018 Jun;40(6):473-479. doi: 10.1016/j.braindev.2018.02.005.
  42. Spinal muscular atrophy with respiratory distress type 1: A child with atypical presentation. Chiu ATG, Chan SHS*, Wu SP, Ting SH, Chung BHY, Chan AOK, Wong VCN. Child Neurology Open. 2018 Apr 19;5:2329048X18769811. doi: 10.1177/2329048X18769811.
  43. Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy. Mercuri E, Darras BT, Chiriboga CA, Day JW, Campbell C, Connolly AM, Iannaccone ST, Kirschner J, Kuntz NL, Saito K, Shieh PB, Tulinius M, Mazzone ES, Montes J, Bishop KM, Yang Q, Foster R, Gheuens S, Bennett CF, Farwell W, Schneider E, De Vivo DC, Finkel RS; CHERISH Study Group. New Englang Journal of Medicine. 2018 Feb 15;378(7):625-635. doi: 10.1056/NEJMoa1710504.
  44. NDUFA9 point mutations cause a variable mitochondrial complex I assembly defect. Baertling F, Sánchez-Caballero L, van den Brand MAM, Fung CW, Chan SH, Wong VC, Hellebrekers DME, de Coo IFM, Smeitink JAM, Rodenburg RJT, Nijtmans LGJ. Clinical Genetics. 2018 Jan;93(1):111-118. doi: 10.1111/cge.13089.
  45. X-linked dilated cardiomyopathy with mutation in the 5’splice site intron 1 of Dystrophin gene with Utrophin upregulation. Chan SHS#*, Ho RSL, Lo IFM, Kan AMC, Lun KS. Journal of Paediatric Neurology 2018;16(1):29-34
  46. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. Finkel RS, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J, Chiriboga CA, Saito K, Servais L, Tizzano E, Topaloglu H, Tulinius M, Montes J, Glanzman AM, Bishop K, Zhong ZJ, Gheuens S, Bennett CF, Schneider E, Farwell W, De Vivo DC; ENDEAR Study Group. New England Journal of Medicine. 2017 Nov 2;377(18):1723-1732. doi: 10.1056/NEJMoa1702752.
  47. Parental restriction reduces the harmful effects of in-bedroom electronic devices. Fu KW, Ho FKW, Rao N, Jiang F, Li SL, Lee TM, Chan SHS, Yung AW, Young ME, Ip P*. Archives of Disease in Childhood. 2017 Jun 29. pii: archdischild-2017-312639. doi: 10.1136/archdischild-2017- 312639.
  48. Cytoplasmic body pathology in severe ACTA1-related myopathy in the absence of typical nemaline rods. Donkervoort S, Chan SHS, Hayes LH, Bradley N, Nguyen D, Leach ME, Mohassel P, Hu Y, Thangarajh M, Bharucha-Goebel D, Kan A, Ho RSL, Reyes CA, Nance J, Moore SA, Foley AR, Bönnemann CG*. Neuromuscular Disorders. 2017 Jun;27(6):531-536. doi: 10.1016/j.nmd.2017.02.012.
  49. Clinical Outcomes in Duchenne Muscular Dystrophy: A Study of 5345 Patients from the TREAT-NMD DMD Global Database. Koeks Z, Bladen CL, Salgado D, van Zwet E, Pogoryelova O, McMacken G, Monges S, Foncuberta M, Kekou K, Kosma K, Dawkins H, Lamont L, Bellgard MI, Roy AJ, Chamova T, Guergueltcheva V, Chan S, Korngut L, Campbell C, Dai Y, Wang J, Barišić N, Brabec P, Lähdetie J, Walter MC, Schreiber-Katz O, Karcagi V, Garami M, Herczegfalvi A, Viswanathan V, Bayat F, Buccella F, Ferlini A, Kimura E, van den Bergen JC, Rodrigues M, Roxburgh R, Lusakowska A, Kostera-Pruszczyk A, Santos R, Neagu E, Artemieva S, Rasic VM, Vojinovic D, Posada M, Bloetzer C, Klein A, Díaz-Manera J, Gallardo E, Karaduman AA, Oznur T, Topaloğlu H, El Sherif R, Stringer A, Shatillo AV, Martin AS, Peay HL, Kirschner J, Flanigan KM, Straub V, Bushby K, Béroud C, Verschuuren JJ, Lochmüller H*. Journal of Neuromuscular Diseases. 2017;4(4):293-306.
  50. Magnetic Resonance Imaging in mild recessive RYR1 gene-related congenital myopathies: Genetic and histopathological correlation. GHT Ng, JJK Ip, SHS Chan, RSL Ho, WWM Lam Hong Kong Journal of Radiology. 2017;20:53-58
  51. Is it or is it not vaccine-associated paralytic poliomyelitis: A Case Report of Acute Flaccid Paralysis after Oral Polio Vaccine Booster dose. Chung I, Chung B, Chan SHS*. Hong Kong Journal of Paediatrics (new series) 2016;21:105-10
  52. Prevalence and characteristics of Chinese patients with Duchenne and Becker muscular dystrophy: A territory-wide collaborative study in Hong Kong. Chan SHS#*, Lo IFM, Cherk SWW, Cheng WW, Fung ELW, Yeung WL, Ngan M, Lee WC, Kwong L, Wong SN, Ma CK, Tai SM, Ng GSF, Wu SP, Wong VCN. Child Neurology Open. 2015 May 26;2(2):2329048X15585345. doi: 10.1177/2329048X15585345.
  53. Spinal primitive neuroectodermal tumor mimicking chronic inflammatory demyelination polyneuropathy: a case report and review of literature. Chan SH*, Tsang DS, Wong VC, Chan GC. Journal of Child Neurology. 2015 Feb;30(2):254-8. doi: 10.1177/0883073814527160.
  54. The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations. Bladen CL, Salgado D, Monges S, Foncuberta ME, Kekou K, Kosma K, Dawkins H, Lamont L, Roy AJ, Chamova T, Guergueltcheva V, Chan S, Korngut L, Campbell C, Dai Y, Wang J, Barišić N, Brabec P, Lahdetie J, Walter MC, Schreiber-Katz O, Karcagi V, Garami M, Viswanathan V, Bayat F, Buccella F, Kimura E, Koeks Z, van den Bergen JC, Rodrigues M, Roxburgh R, Lusakowska A, Kostera-Pruszczyk A, Zimowski J, Santos R, Neagu E, Artemieva S, Rasic VM, Vojinovic D, Posada M, Bloetzer C, Jeannet PY, Joncourt F, Díaz- Manera J, Gallardo E, Karaduman AA, Topaloğlu H, ElSherif R, Stringer A,Shatillo AV, Martin AS, Peay HL, Bellgard MI, Kirschner J, Flanigan KM, Straub V, Bushby K, Verschuuren J, Aartsma-Rus A, Béroud C, Lochmüller H. Human Mutation. 2015;36(4):395-402.
  55. Limb girdle muscular dystrophy due to LAMA2 mutations: diagnostic difficulties due to associated peripheral neuropathy. Chan SH#, Foley AR, Phadke R, Mathew AA, Pitt M, Sewry C, Muntoni F*. Neuromuscular Disorders. 2014 Aug;24(8):677-83. doi: 10.1016/j.nmd.2014.05.008.
  56. Neuromuscular junction acetylcholinesterase deficiency responsive to albuterol. Chan SH#, Wong VC, Engel AG. Pediatric Neurology. 2012 Aug;47(2):137-40. doi:10.1016/j.pediatrneurol.2012.04.022.
  57. Anti-NMDA receptor encephalitis with atypical brain changes on MRI. Chan SH#, Wong VC, Fung CW, Dale RC, Vincent A. Pediatric Neurology. 2010 Oct;43(4):274-8. doi: 10.1016/j.pediatrneurol.2010.05.004.
  58. Selective dorsal rhizotomy in Hong Kong: multidimensional outcome measures. Chan SH#*, Yam KY, Yiu-Lau BP, Poon CY, Chan NN, Cheung HM, Wu M, Chak WK. Pediatric Neurology. 2008 Jul;39(1):22-32. doi: 10.1016/j.pediatrneurol.2008.03.017.
  59. Neurodevelopmental outcomes of extreme low birth weight infants born between 2001 – 2002: High Risk Follow-up Working Group (Kowloon Region). SHS Chan, FMY Lee*, KML Tang, MMF Wu, TF Tong, LCK Leung, LTW Chan, CW Law, YC Ho, LCK Ma. Hong Kong Med Journal. 2008 Feb;14(1):21-8.
  60. Prevalence study of cerebral palsy in Hong Kong. Yam WK, Chan HS, Tsui KW, Yiu BP, Fong SS, Cheng CY, Chan CW; Working Group on Cerebral Palsy, HK Society of Child Neurology and Developmental Paediatrics. Hong Kong Medical Journal 2006: 12(3):180-4.
  61. Neuroimpairment, activity limitation and participation restriction among children with cerebral palsy in Hong Kong. HSS Chan#, PHB Lau, KH Fong, D Poon, CCC Lam. Hong Kong Med Journal. 2005 Oct;11(5):342-50.
  62. Ventricular Aneurysm complicating neonatal coxackie B4 myocarditis. Chan SHS* Lun KS, Lee WH. Paediatrics Cardiology. 2001: 22(3);247-249
  63. Review on Group B Streptococcal Infection. SHS Chan*, KM Wan, WH Lee. Hong Kong Journal of Paediatrics. 2000:5(2); 166-174

 

 

CONFERENCE PAPERS

  1. Title: Establishment of integrated, personalized respiratory and motor telerehab program for paediatric patients with hereditary neuromuscular disorders: What is next ?
    Michael KL Yu, Alice YY Chiu, SK Chau, Jaime SR Duque, Wilfred HS Wong, Sophelia HS Chan*.
    The Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association and Hong Kong College of Paediatric Nursing Joint Annual Scientific meeting on 27th Jan 2024.
    [#Best Oral Presentation 2nd Prize, Presented by Research Assistant Dr Yu]
  2. Title: Physiotherapy training for a patient with spinal muscular atrophy on nusinersen treatment – a case study
    MW Cheung, Sophelia HS Chan, YB Ho, Stephen WW Chan.
    The Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association and Hong Kong College of Paediatric Nursing Joint Annual Scientific meeting on 27th Jan 2024.
    [Presented by HKCH Senior Physiotherapist Ms Cheung]
  3. Title: The establishment of an X-linked dilated cardiomyopathy patient-derived induced pluripotent stem cells disease model to study the effect of mutation-correction and for drug screening.
    Stephen Y Cheng, Anna HY Law, S Zhu, J Lui, Jacky TY Chan, KM Ng, Ellen NY Poon, YF Cheung, HF Tse, Godfrey CF Chan, Sophelia HS Chan*.
    The 21st Asian and Oceanian Myology Center Meeting in Shanghai, China 26-28 Oct 2023
    [#Best Poster Presentation, Presented by Research Assistant Dr Cheng]
  4. Title: Dystrophin expression and epigenetic drug treatment restore the dysregulated gene expressions in XLDCM patient-derived cardiomyocytes disease model
    J Lui, Anna HY Law, S Zhu, Stephen Y Cheng,Jacky, YF Cheung, HF Tse, Godfrey CF Chan, Sophelia HS Chan*.
    The 21st Asian and Oceanian Myology Center Meeting in Shanghai, China 26-28 Oct 2023
    [# Awarded the Traveler Scholarship for Youth, Presented by Research Assistant Mr Liu]
  5. Title: Improvement in motor function, health-related quality of life and self-reported outcomes in patients and their families with spinal muscular atrophy
    Hayley HN Ip, Michael KL Yu, PK Cheng, YS Chau, Ruth SY Leung, Wilfred HS Wong, Sophelia HS Chan*
    The 21st Asian and Oceanian Myology Center Meeting in Shanghai, China 26-28 Oct 2023
    [#Awarded the Traveler Scholarship for Youth, Presented by Paediatric Trainee Dr HHN Ip]
  6. Title: Use of gait analysis in detecting the functional changes of a patient with spinal muscular atrophy
    Nar Chi Chan*, Miko LM Lao, Ivy KK Wong, Helen KF Chan, Joyce HY Lai, Stephen WW Chan, Sophelia HS Chan
    The 21st Asian and Oceanian Myology Center Meeting in Shanghai, China 26-28 Oct 2023
    [#Best Poster Presentation, Presented by Prof Chan NC (Clinical Practice) Polytechnic University]
  7. Title: Clinical and genetic characteristics of 8 Chinese patients with ACTA1 congenital myopathy.
    Sharon TF Fung, Sophelia HS Chan*
    The 21st Asian and Oceanian Myology Center Meeting in Shanghai, China 26-28 Oct 2023
    [Poster presentation by Paediatric Neurologist Dr Fung]
  8. Title: Genetic and clinical characterization of fascioscapulohumeral muscular dystrophy type 1 in Hong Kong.
    Shirley Pang, Michael KL Yu, Yuan Gao, Anna KY Kwong, Patrick TW Law, Khan Hira, Stephen Y Cheng, Godfrey CF Chan, Sophelia HS Chan*
    The 21st Asian and Oceanian Myology Center Meeting in Shanghai, China 26-28 Oct 2023
    [Poster presentation by Adult Neurologist Dr Pang]
  9. Title: How does nusinersen affect scoliosis progression in spinal muscular atrophy? A prospective longitudinal study.
    HNH Ip, MKL Yu, WHS Wong, KYH Kwan, SHS Chan*
    16th Asian Oceanian Congress of Child Neurology Harmonizing the Diversity in Child Neurology. Bangkok, Thailand. 4-6 Aug 2023
    [Selected Oral Presentation, Presented by Dr SHS Chan]
  10. Title: Covid-19 associated acute motor sensory axonal neuropathy in an 11-year-old boy. QY Lim, JR Duque, S Chan, W Tso, C Chau, YL Lau.
    41st Annual Meeting of the European Society of Paediatric Infectious Diseases. 8-12 May 2023.
    [Poster presentation by Paediatric Trainee Dr Lim]
  11. Title: From establishment to clinical applications of Hong Kong Neuromuscular Disorder Patient Registry: An influential research platform.
    Yu KL, Rose JS, Wong HS, Gao Y, Pang YY, Chan CF, Chan HS*.
    TREAT-NMD 7th International Conference organized by TREAT-NMD neuromuscular network, Poster presentation, 7-9 Dec 2022: Vancouver, Canada.
    [Poster Presentation by PhD student Mr Michael Yu]
  12. Title: Genetic diagnosis and clinical characterisation of FacioScapuloHumeral Muscular Dystrophy in Hong Kong Chinese patients using molecular combing and whole exome sequencing.
    MKL Yu, Y Gao, S Pang, AKY Kwong, PTW Law, H Khan, S Y Cheng, W Andong, WN Lee, GCF Chan, SHS Chan*
    The Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association and Hong Kong College of Paediatric Nursing Joint Annual Scientific meeting on 6th Nov 2022.
    [# Best Oral Presentation 2nd price presented by PhD student Mr. Michael Yu]
  13. Title: Determination of DLC1 isoform 1 (DLC1-i1) as a gene therapy for the treatment of spinal muscular atrophy.
    T Shi, B Liao, W Xiong, S Chan, J Liu, M Cheung*
    World Muscle Society Congress 2022. 11-15 Oct 2022.
    Neuromuscular Disorders. Volume 32, Supplement 1, S62, OCTOBER 2022. https://www.sciencedirect.com/science/article/pii/S0960896622002905#!
    [# Selected late-breaking news oral presentation presented by Dr Martin Cheung from School of Biomedical Science]
  14. Title: Diagnosing Titinopathy: lessons from a multi-omics pilot study in Hong Kong.
    Y Zhang, X Ling, L Yao, SHS Chan*, A Javed*.
    World Muscle Society Congress 2022. 11-15 Oct 2022
    [E-poster] https://www.nmd-journal.com/article/S0960-8966(22)00230-9/fulltext. Neuromuscular Disorders. Volume 32, Supplement 1, S47-S48, OCTOBER 2022. DOI: https://doi.org/10.1016/j.nmd.2022.07.028
    [E-Poster Presentation by PhD student Ms Zhang]
  15. Title: COVID-19 Vaccine Hesitancy Among Neuromuscular Disorder Children and Adolescents.
    Yu KL, Wong HS, Suen A, Lau YY, Rose JS , Chan HS*.
    17th International Child Neurology Congress organized by The International Child Neurology Association, 3-7 Oct 2022: Antalya, Turkey.
    [Poster presentation by Dr Chan SHS]
  16. Title: Impact of COVID-19 pandemic on healthcare utilisation and psychosocial well-being of children with neuromuscular disorder.
    Yu KL, Tso WY, Yip KM, Wong HS, Yiu KF, Chan CF, Ip P, Chan HS.
    17th International Child Neurology Congress organized by The International Child Neurology Association, 3-7 Oct 2022, Antalya, Turkey.
    [Poster Presentation by Dr Chan SHS]
  17. Title: Genetic diagnosis of facioscapulohumeral muscular dystrophy in Hong Kong Chinese patients using molecular combing.
    AKY Kwong, Y Gao, S Pang, PTW Law, MKL Yu, SY Cheng, GCF Chan, SHS Chan.*
    The 20th Asian and Oceanian Myopathy Center (AOMC) Meeting in conjunction with the National Scientific Meeting of Indonesian Neurological Association Jun 9-12,2022.
    [# Best E-Poster Presentation 3rd Price presented by Postdoc Dr Kwong]
  18. Title: Ranking variant pathogenicity using Exomiser facilitated the identification of the missing second mutation in three recessive cases of congenital myopathy.
    Y Lei, W Yang, SHS Chan*.
    The 20th Asian and Oceanian Myopathy Center (AOMC) Meeting in conjunction with the National Scientific Meeting of Indonesian Neurological Association (PERDOSSI) Jun 9-12,2022.
    [# Best E-Poster Presentation 1st Price presented by MPhil student Mr. Lei]
  19. Title: Debilitating osteochondral manifestations in patients with congenital insensitivity to pain with anhidrosis (CIPA) due to NTRK1 mutation.
    VWY Li, SHS Chan*, EE Kuong.
    The 20th Asian and Oceanian Myopathy Center (AOMC) Meeting in conjunction with the National Scientific Meeting of Indonesian Neurological Association (PERDOSSI) Jun 9-12,2022.
    [E-Poster Presentation – Paediatric trainee Dr Li]
  20. Title: Reactogenicity and Immunogenicity of the COVID-19 Vaccines BNT162b2 and Sinovac-CoronaVac in Patients with Hereditary or Acquired Neuromuscular Disorders on Immunomodulatory Therapies.
    KL Yu, JSR Duque, D Leung, S Cheng, SM Chan, M Peiris, SHS Chan*, YL Lau*.
    ASPR 2021 Annual Congress. 10-12 December 2021.
    [Poster Presentation - PhD student Mr Yu]
  21. Title: Diagnostic value of whole exome sequencing (WES) in Chinese paediatric onset neuromuscular diseases.
    Tsang MHY ,Chiu ATG ,Liang R ,Yu MHC ,Fung JLF ,Wong VCN ,Muntoni F ,Chung BHY*, Chan SHS*.
    Health Research Symposium 2021 – The 10th Anniversary of the Establishment of the Health and Medical Research Fund. 23 November 2021.
    [E-Poster Presentation – Dr Chan SHS]
  22. Title: Establishment of Hong Kong Neuromuscular Disorder Patient Registry.
    Yu KL, Wong HS, Gao Y, Rose JS, Chan CF, Chan SHS*.
    Joint Annual Scientific Meeting 2021 organized by The Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association and Hong Kong College of Paediatric Nursing, 30th October. 2021.
    [Poster Presentation – PhD student Mr Yu]
  23. Title: The impact of nusinersen treatment on musculoskeletal progression in patients with spinal muscular atrophy.
    HHN Ip, MKY Yu, PK Cheng, KYH Kwan, NLW So, E Kuong, SHS Chan*.
    The Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association and Hong Kong College of Paediatric Nursing will be hosting a joint Annual Scientific meeting on 30th October 2021.
    [# Best Oral Presentation 2nd Price presented by Year 6 MBBS Medical Student Ms. Ip]
  24. Title: Treatment outcomes and The Improvement in Health-related Quality of Life in Patients and Their Families for Patients with SMA After 1 Year of Nusinersen Treatment.
    Cheng PK, Yu KL, Ip HN, Cheng HL, P Lam, P Cheng, Lee SL, Chan CF, Ip YT, Chan SHS*.
    19th Asian-Oceanian Myology Center Meeting organized by Asian and Oceanian Myology Center, Busan, South Korea June 10-11, 2021.
    [Poster Presentation – Ms. Cheng, SMA nurse coordinator]
  25. Title: TTN mutations in limb girdle muscular dystrophy with calpainopathy-like presentation in 2 siblings.
    Y Lei, W Yang, SHS Chan*.
    19th Asian-Oceanian Myology Center Meeting, Busan Korea, June 10-11, 2021.
    [# Best E-Poster Presentation Award presented by MPhil student Mr Lei]
  26. Title: Disrupted medical care, rehabilitation and poorer psychosocial well-being for children with special educational needs during the Covid-19 pandemic.
    WWY Tso, TMC Lee , SL Lee, ICK Wong , B Chung , SHS Chan, F Jiang , WHS Wong , RS Wong ,KTS Tung , JCS Yam , GT Chua, LK Leung , S Jin , G Wang , P Ip*
    Joint Annual Scientific Meeting 2020 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 7 Nov2020.
    [E-Poster presentation by DBP Specialist Dr Tso]
  27. Title: Facioscapulohumeral dystrophy type 1 – From infantile to late adult onset.
    WY Leung , HM Luk , V Vardhanabhuti , Y Gao , KF Hui , WY Lau , PHT Young , TCJ Li , LWE Fung, ATG Chiu, JLF Fung, FMI Lo , BHY Chung, YF Cheung, SHS Chan*.
    Joint Annual Scientific Meeting 2020 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 7 November 2020.
    [E-Poster Presentation by Paediatric trainee Dr Leung]
  28. Title: Improvement in health-related quality of life in patients and their families, with SMA after 1 year of nusinersen treatment.
    YS Chau , MKY Yu, HHN Ip, RHL Cheng, PL Lam, P Cheng, SL Lee, GCF Chan, Brian YT Ip
    ,SHS Chan *.
    Joint Annual Scientific Meeting 2020 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 7 November 2020.
    [# Poster Presentation 1st price presented by Ms. Chau, SMA nurse coordinator]
  29. Title: The prevalence and healthcare utilization of rare neurological diseases in Hong Kong 2014-2018.
    ATG Chiu, JJ Li, RSK Chang, CCY Chung, WHS Wong, JS Zeng, BHY Chung, SHS Chan*.  
    Joint Annual Scientific Meeting 2020 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 7 November 2020.
    [E-Poster Presentation - Paediatric Neurology trainee Dr Chiu ATG]
  30. Title: Patient-derived induced pluripotent stem cells differentiated cardiomyocytes as platform for disease modeling for X-linked dilated cardiomyopathy.
    S Zhu, MR Deng, AHY Law, ENY Poon, CW Lo, R Liang, AKY Kwong, KM Ng, HF Tse, GCF Chan, SHS Chan*.
    World Muscle Society Congress 2020. Neuromuscular Disorder ;2020 (30), Supplement 1, S106; https://www.sciencedirect.com/science/article/abs/pii/S0960896620304028.
    [E-Poster Presentation - PhD student Ms. Zhu]
  31. Title: Clinical burden of influenza-associated neurological complications in Hong Kong Paediatric patients, 2014-2018.
    MKL Yu, CLP Pik, WHS Wong, ACC Ho, ATG Chiu, GCF Chan**, SHS Chan**.
    Joint Annual Scientific Meeting 2019 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 28 Sept 2019.
    [Poster Presentation - MPhil student Mr Yu]
  32. Title: Collagen VI and XII related myopathies: Clinical variability and novel variants found in Hong Kong patients.
    SHS Chan*, AKY Kwong, MHY Tsang, RSL Ho, HM Luk, H Lee, BHY Chung, CG Bonnemann.
    Annual Scientific Meeting 2019 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 28 September 2019.
    [Poster Presentation - Dr SHS Chan]
  33. Title: Reliability and validity of performance of the upper limb module for Chinese patients with Duchenne muscular dystrophy: A new useful clinical tool to monitor the disease progress and as outcome measure for therapeutic drug trial.
    Chiu AYY, Choi SWC, Hui CKC, Li YS, Lee SL, Chan SHS**.
    Joint Annual Scientific Meeting 2019 jointly organized by the Hong Kong Paediatric Society, Hong Kong College of Paediatricians, Hong Kong Paediatric Nurses Association, Hong Kong College of Paediatric Nursing. Hong Kong Children’s Hospital. 28 September 2019.
    [# Best Poster Presentation presented by Research Assistant Mr Li]
  34. Title: Muddling through muscle genes – The quest for diagnosis in 50 patients with neuromuscular disorders using whole exome sequencing.
    MHY Tsang, ATG Chiu, BMH Kwong, R Liang, MHC Yu, KS Yeung, WHK Ho, Cr CCY Mak, GKC Leung, SLC Pei, JLF Fung, VCN Wong, F Muntoni, BHY Chung**, SHS Chan**.
    15th Asian Oceanian Congress of Child Neurology in Kuala Lumpur. 19-21 Sept 2019.
    [Poster Presentation - PhD student Ms. Tsang]
  35. Title: Collagen VI related myopathy: Clinical variability of triple helical domain mutations of COL6A mutations.
    SHS Chan*, AKY Kwong, HM Luk, IFM Lo, STH Fung, MHY Tsang, BHY Chung, AOK Chan.
    International Child Neurology Congress. Mumbai, India. 14th -18th Nov 2018
    [Poster Presentation - Dr. SHS Chan]
  36. Title: Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong.
    MHY Tsang, BMH Kwong, SLC Pei, GKC Leung, KS Yeung, CCY Mak, MHC Yu, JLF Fung, M Liang, BHY Chung**, SHS Chan**.
    The 17th AOMC & 28th MSN Annual Scientific Meeting, Kuala Lumpur, Malaysia. 27-29 July 2018
    [Poster Presentation by PhD student Ms. Tsang]
    The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong. 28th July 2018
    [Oral Presentation - PhD student Ms. Tsang]
  37. Title: Patient-derived induced pluripotent stem cells differentiated cardiomyocytes as platform for disease modeling for X-linked dilated cardiomyopathy.
    R Liang, MR Deng, AHY Law, K Boheler, SHS Chan**, GCF Chan**.
    The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong. 28th July 2018.
    [# Best Poster Presentation presented by Research Assistant Mr. Liang]
  38. Title: Multi-dimensional Impact of Paediatric Neuromuscular Disorders on Parents and Families.
    YT Ip, R Liang, SHS Chan*.
    The 13th Congress of Asian Society for Pediatric Research 6-8 Oct 2017.
    [Poster Presentation - Dr SHS Chan]
  39. Title: Muscle strength and pulmonary function in Duchenne Muscular Dystrophy.
    SHS Chan    *, R Liang, A Chiu, SKC Chau, W Wong, SL Lee.
    The 13th Congress of Asian Society for Pediatric Research 6-8 Oct 2017.
    [Poster Presentation - Dr SHS Chan]
  40. Title: Miller Fisher Syndrome in Pediatric Population in HK.
    WK Chan, EKC Yau, SF Ng, SHS Chan, ELW Fung, L Kwong, CH Tsang, SP Wu, Louis CK Ma, CH Ko.
    The 13th Congress of Asian Society for Pediatric Research 6-8 Oct 2017.
    [Poster Presentation - Paediatric trainee Dr WK Chan]
  41. Title: Neuromuscular involvement in children with mitochondrial disease: A single centre experience.
    ATG Chiu, CW Fung, SHS Chan*, Richard Rodenburg, Virginia CN Wong. The 13th Congress of Asian Society for Pediatric Research 6-8 Oct 2017.
    [Poster Presentation - Paediatric Neurology Subspecialty trainee Dr Chiu]
  42. Title: Bone health among boys with Duchenne Muscular Dystrophy before and after initiation of glucocorticoids.
    JYL Tung, SHS Chan.
    The 13th Congress of Asian Society for Pediatric Research 6-8 Oct 2017.
    [Poster Presentation - Paediatric Endocrinologist Dr Tung]
  43. Title: Long term follow-up of three children with COLQ-related congenital Myasthenic syndrome of different mutations responsive to salbutamol.
    SHS Chan*, AOK Chan, AG Engel.
    Hong Kong College of Paediatricians 4th Annual Scientific Meeting cum 5th HK Guangdong Shanghai Chongquing Paediatric Exchange Meeting. 2-3 Dec 2016.
    [Poster Presentation - Dr SHS Chan]
  44. Title: Improving genetic diagnosis by whole exome sequencing in rare hereditary peripheral neuropathies.
    CHAN SHS* , Fung CW, Chung HY Brian.
    Hong Kong College of Paediatricians 4th Annual Scientific Meeting cum 5th HK Guangdong Shanghai Chongquing Paediatric Exchange Meeting. 2-3 Dec 2016.
    [Poster Presentation - Dr SHS Chan]
  45. Title: Congenital myopathies – Characteristic of different subtypes in Hong Kong.
    Chan SHS*, Ho RSL, Chan AOK, Ip JJK, Wong S, Ng GSF, Lee HCH, Cheng Y, Liu KT, Lee CN ,Fung STH, Cherk SWW, Chan TSK, Lam WMW, Shek WH, Wong VCN.
    The 29th Annual Scientific Meeting of the Hong Kong Neurological Society: Neuromuscular Disorder Symposium. Hong Kong 5 Nov 2016.
    [# Oral Free Paper Presentation First Price presented by Dr SHS Chan]
  46. Title: Congenital Myopathies: genotypic and phenotypic study in Hong Kong.
    Chan SHS*, Ho RSL, Chan AOK, Ip JJK, Wong S, Ng GSF, Lee HCH, Cheng Y, Liu KT, Lee CN, Fung STH, Cherk SWW, Chan TSK, Lam WMW, Shek WH, Wong VCN.
    15th Asian and Oceanian Myology Center Annual Scentific Meeting in conjunction with 20th Taiwan Child Neurology Society Meeting, Hsinchu, Taiwan. 26-29 May 2016.
    [Poster Presentation - Dr SHS Chan]
  47. Title: Myofibrillar myopathies: A clinicopathological study of 13 cases.
    Wong S, Lee CN, Lee H, Cheng Y, Cheung YF, Fu M, Sheng B, Ho R, Ho LC, Chang SK, Fung S, Yau E, Kan A, Chan A, Chan S*.
    15th Asian and Oceanian Myology Center Annual Scientific Meeting in conjunction with 20th Taiwan Child Neurology Society Meeting, Hsinchu, Taiwan. 26-29 May 2016.
    [Poster Presentation by Pathologist Dr Wong S]
  48. Title: A DYNC1H1 mutation causes a lower extremity predominance spinal muscular atrophy
    SHS Chan*, B Chung, C Mak , J Ip , EJ Kamsteeg.
    15th Asian and Oceanian Myology Center Annual Scientific Meeting in conjunction with 20th Taiwan Child Neurology Society Meeting, Hsinchu, Taiwan. 26-29 May 2016.
    [Poster Presentation - Dr SHS Chan]
  49. Title: Case Series of Anti-N-Methyl-D-Aspartate Receptor (Anti-NMDAR) Encephalitis in Children in Hong Kong.
    Ho ACC, Chan E, Cherk SWW, Fung STH, Fung ELW, Wong SN, Yau EKC, Tsui KW, Ma KH, Wong VCN, Chan SHS*.
    14th Asian and Oceanian Congress of Child Neurology 11-14 May 2016, Fukuoka, Japan.
    [Poster Presentation - Dr Chan SHS]
  50. Title: Guillian Barre Syndrome (GBS) of Chinese children in Hong Kong. A retrospective study focusing on subtype diagnosis, management and outcome.
    WC Lee, SHS Chan, W Wong, E Yau, G Ng, S Cherk, M Yau, E Fung, KH Ma, SP Wu, Louis CK Ma, MM Yau, KT Liu, KY Chan, CVN Wong.
    14th Asian and Oceanian Congress of Child Neurology 11-14 May 2016, Fukuoka, Japan.
    Brain and Development 2016;39: 167.
    [Poster Presentation - Dr SHS Chan]
  51. Title: Bone health among boys with Duchenne muscular dystrophy before initiation of glucocorticosteroids.
    JYL Tung, SHS Chan, PT Cheung.
    7th International Conference on Children’s Bone Health. Austria, Salzburg 27-30 Jun, 2015.
    [Poster Presentation -endocrinologist Dr Tung].
  52. Title: Health-related quality of life, psychosocial functioning and sleep quality of children with Duchenne muscular dystrophy and their parents in Hong Kong – A Pilot Study.
    Tang OC, Chan SHS**, & Lau EYY**
    13th Asian and Oceania Congress of Child Neurology 2015. Taipei city, Taiwan: 14-17
    May,2015.
    [Poster Presentation - Dr SHS Chan]
  53. Title: Mild recessive RYR1-related congenital myopathy - the expanding clinical, pathological, radiological and genetic spectrum.
    Chan SHS*, Chan AOK, Ho RSL, Ip JJK, Yeung M, Lam CW, Lam WWM, Wong VCN.
    3th Asian and Oceanian Congress of Child Neurology 2015. Taipei City, Taiwan.14-17 May, 2015.
    [Oral presentation - Dr SHS Chan]
  54. Title: Cytoplasmic body pathology in severe ACTA1-related myopathy in the absence of typical nemaline rod histology.
    S Donkervoort, SHS Chan, L Hotchkiss, N Bradley, D Nguyen, ME.Leach, P Mohassal, Y Hu, M Thangarajh, A Kan, C Reyes, J Nance, SA Moore, AR Foley, CG Bönnemann.
    20th International World Muscle Society Congress 2015, Brighton, UK:30 Sep-4 Oct 2015.
    Neuromuscul Disord. 2015:25(S2):S278.
    [Poster presentation - Dr S Donkervoort from NIH NINDS]
  55. Title: Congenital Myopathies: characteristic and Subtypes in Hong Kong.
    Chan SHS*, Ho RSL, Chan AOK, Ip JJK, Wong S, Ng GSF, Lee HCH, Cheng Y, Liu KT, Lee CN, Fung STH, Cherk SWW, Chan TSK, Lam WMW, Shek WH, Wong VCN.
    20th International World Muscle Society Congress 2015 ,Brighton, UK :30 Sep - 4 Oct 2015.
    Neuromuscul Disord. 2015:25(S2):S278.
    [Poster Presentation - Dr SHS Chan]
  56. Title: Diagnostic pitfall with use of alpha-dystroglycan immunostain in perimortem muscle biopsies.
    IFM Lo, WWS Cherk,WWS ChengLWE Fung, WL Yeung, M Chu, WC Lee, A Kan, S Chan.
    19th Annual meeting of the American Association of Neuropathologists, Portland, Oregon, USA.12-15 Jun 2014. J of Neuropathology & Experimental Neurology 2014;73(6):594- 595.
    [Poster Presentation -Pathologist Dr Amanda Kan]
  57. Title: Guillain Barré Syndrome in Children in Hong Kong.
    SHS Chan*, KY Chan, Eric Yau, Grace Ng, CK Ma, SP Wu, S Cherk, M Ngan, K Kwong, MM Yau, M Yau, Eva Fung, Lee WC, Liu KT, Ma KH, VCN Wong.
    13th Asian and Oceanian Myology Centre Scientific Meeting, Bangkok, Thailand. 14-17 May 2014.
    [Poster Presentation - Dr SHS Chan]
  58. Title: An X-linked dominant mutation in LAMP2 causing Danon disease associated with myotonia expanding the spectrum.
    Sophelia Chan, Amanda Kan, Tse HF.
    18 th International Congress of the World Muscle Society. Asilomar, USA. 1-6 Oct 2013 Neuromuscul Disord. 2013;23(9-10):821.
    [Poster Presentation - Dr SHS Chan]
  59. Title: Territory wide study of patients with dystrophinopathy in Hong Kong.
    SHS Chan*, IFM Lo, S Cherk, WWS Cheng, E Fung, WL Yeung, Lee WC, S Wong, CKL Ma, SM Tai, MM Yau, G Ng, SP Wu, CVN Wong.
    18th International congress of the World Muscle Society. Asilomar, USA. 1-6 Oct 2013.
    Neuromuscul Disord. 2013;23(9-10):821.
    [Poster Presentation - Dr SHS Chan]
  60. Title: Phenotypic heterogeneity in 2 sisters with SMAD3-associated aneurysms- osteoarthritis syndrome (AOS) - insights into the pathogenesis from phenotypic assessment and immunohistochemical analysis using patient-derived dermal fibroblasts. Chung BHY., Luk HM, Chan SHS., Shen WY and Hinek A.
    34th Annual David W Smith Workshop, Mont Tremblant, Quebec, Canada, 9-15 Aug 2013.
    (Publication No. : 218249)
    [Poster Presentation - Dr BHY Chung]
  61. Title: Danon disease in a Chinese family with atypical presentation.
    Amanda Kan    , Sophelia Chan
    American Association of Neuropathologists, Inc. 88th Annual Meeting, Chicago, IL. 21-24 Jun
    2012. J Neuropathl Exp Neurol 2012; 71(6):547Y600
    [Poster Presentation - Pathologist Dr Amanda Kan]
  62. Title: A girl with atypical chronic inflammatory demyelinating polyneuropathy.
    SHS Chan, W Mak, VCN Wong.
    11th International Child Neurology Congress, Cairo, Egypt . 2-7 May 2010.The International Journal of Child Neuropsychiatry. 2010; 138: 90
    [Poster Presentation - Dr SHS Chan]
  63. Title: Anti-NMDAR encephalitis—An encephalitis lethargica-like illness.
    SHS Chan*, VCN Wong, CW Fung, RC Dale, A Vincent, AWY Yung, SL Lee.
    11th International Child Neurology Congress Cairo, Egypt, 2-7 May 2010. The International Journal of Child Neuropsychiatry. 2010;438:184
    [Poster Presentation - Dr SHS Chan]
  64. Title: A child with painless idiopathic orbital myositis – a case report.
    SHS Chan*, Dorothy Chu, So Lun Lee, VCN Wong, Chun Yu Wong.
    10th Asian Oceanian Congress of Child Neurology 2009 Daegu, Korea. 10-13 Jun 2009
    [Poster Presentation - Dr SHS Chan]
  65. Title: Fluctuating weakness in chronic inflammatory demyelinating polyneuropathy
    SHS Chan, VCN Wong
    10th Asian Oceanian Congress of Child Neurology 2009 Degu, Korea. 10-13 Jun 2009
    [Poster Presentation - Dr SHS Chan]
  66. Title: Selective dorsal rhizotomy in Hong Kong: A multidimensional assessment of outcome.
    HSS Chan*, N Chan, C Poon, B Yiu, KY Yam.
    4th World Congress for Neurorehabilitation. Journal of Neurorehabilitation and Neural Repair 15 Feb 2006. [Oral Presentation - Dr HSS Chan]

 

 

Book Chapters

  1. PNAHK 2019 Publication: Paediatric Neurology Vade Mecum (2019).
    ISBN: 978-988-160-2800.
    Chapter 27: Spinal muscular atrophy. ATC Chiu, SHS Chan.
    Chapter 28:  Peripheral neuropathies. SHS Chan, ATG Chiu.
    Chapter 29:  Myasthenia gravis. ACC Ho, SHS Chan.
    Chapter 31:  Myopathies.  SHS Chan, ATG Chiu.
    Chapter 42:  Nerve conduction studies & Electromyography. SHS Chan. 
    Chapter 45:  Skin and muscle biopsy. SHS Chan.
  2. SHS Chan, CCY Ho. Cerebral Palsy: Chapter 4. In Rose HL Mak, Catherine CC Lam, Cherri CY Ho, May MY Wong (Ed). A primer in Common Developmental Disabilities, Experience at Child Assessment Service, Hong Kong SAR (2006). ISBN 9628868179, 9789628868179
  3. SHS Chan. Developmental Coordination Disorder: Chapter 5. In Rose HL Mak, Catherine CC Lam, Cherri CY Ho, May MY Wong (Ed). A primer in Common Developmental Disabilities, Experience at Child Assessment Service, Hong Kong SAR (2006). ISBN 9628868179, 9789628868179

 

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