Professor Yu-lung Lau (劉宇隆)

MBChB, MD (Hon), FHKAM, FHKCPaed

 

Chair Professor of Paediatrics

Doris Zimmern Professor in Community Child Health

Department of Paediatrics and Adolescent Medicine

School of Clinical Medicine, The University of Hong Kong

 

Specialty

Paediatric Immunology and Infectious Disease

 

Prof YL Lau

 

Prof Yu Lung Lau graduated from the University of Glasgow in 1980. He is currently the Chair Professor of Paediatrics and Doris Zimmern Professor in Community Child Health of The University of Hong Kong (HKU). He has been Head of Paediatrics, Associate Dean of the Faculty of Medicine and Deputy Chief Executive of the Shenzhen Hospital of HKU, President of the Hong Kong Paediatric Society, Hong Kong College of Paediatricians (HKCP) and Asia Society for Paediatric Research.

 

Prof Lau established the Asian Primary Immunodeficiencies Referral Network offering free genetic tests for over 2000 patients in Asia and Africa, and is the Founding President of the Asia Pacific Society for Immunodeficiency (ASPID).

 

Prof Lau is a member of the WHO (WPRO) Technical Advisory Group for Immunisation and Vaccine Preventable Diseases. He is the Chair of Scientific Committee on Vaccine Preventable Diseases and initiated universal childhood PCV vaccination as Chair of Working Group on Pneumococcal Vaccination. He helped introduce the universal screening for maternal HIV infection as Chair of the Scientific Committee on AIDS. He was appointed by the CE HKSAR to be a member of the COVID-19 Expert Advisory Panel in 2022.

 

His research interests include genetics, infectious diseases and immunology. He has published over 500 original papers with an h-index of 98 and supervised over 40 graduate students. He received the Outstanding Researcher Award, the Mrs Gordon Wu Exchange Professorship and the Faculty Knowledge Exchange Award, the Second Prize in Science and Technology of the Ministry of Education and the Outstanding Asian Pediatrician Award. He delivered Guerrero Memorial Lecture, Inaugural Stuart Gan Memorial Lecture, Otto Wolff Lecture, Lata Kumar Lecture and Bill Marshall Memorial Lecture. APSID has established an Oration Lecture in his name to be delivered during the APSID Congress. He was appointed as Justice of Peace in 2020 and awarded Bronze Bauhinia Star in 2022.

 

Contact

Email:

Tel:

Fax:
Office:
(852) 2255-4481
(852) 2855-1523
Department of Paediatrics & Adolescent Medicine
Room 106, 1/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong

 

Research ID

ORCid : https://orcid.org/0000-0002-4780-0289
Google scholar : https://scholar.google.com.hk/citations?hl=zh-TW&user=yIjb9qMAAAAJ
Researchgate : https://www.researchgate.net/profile/Yu_Lau

Scopus: https://www.scopus.com/authid/detail.uri?authorId=7201403380

 

Research

 

Prof YL Lau’s research focuses on

(a) Primary immunodeficiencies (PID), systemic lupus erythematosus (SLE)

(b) Immune responses to pathogens and modulation of immune cells by apoptotic cells

(c) Infectious disease and vaccine study

(d) Thalassaemia and hematopoietic stem cell transplant (HSCT)

 

Citation over 37,922 with h-index 100 & i10-index 401 by Google Scholar

 

Publications in 2024:

  1. Bastard P, Gervais A, Taniguchi M, Saare L, Särekannu K, Le Voyer T, Philippot Q, Rosain J, Bizien L, Asano T, Garcia-Prat M, Parra-Martínez A, Migaud M, Tsumura M, Conti F, Belot A, Rivière JG, Morio T, Tanaka J, Javouhey E, Haerynck F, Duvlis S, Ozcelik T, Keles S, Tandjaoui-Lambiotte Y, Escoda S, Husain M, Pan-Hammarström Q, Hammarström L, Ahlijah G, Abi Haidar A, Soudee C, Arseguel V, Abolhassani H, Sahanic S, Tancevski I, Nukui Y, Hayakawa S, Chrousos GP, Michos A, Tatsi EB, Filippatos F, Rodriguez-Palmero A, Troya J, Tipu I, Meyts I, Roussel L, Ostrowski SR, Schidlowski L, Prando C, Condino-Neto A, Cheikh N, Bousfiha AA, El Bakkouri J; COVID Clinicians; GEN-COVID Study Group; COVID Human Genetic Effort; Peterson P, Pujol A, Lévy R, Quartier P, Vinh DC, Boisson B, Béziat V, Zhang SY, Borghesi A, Pession A, Andreakos E, Marr N, Mentis AA, Mogensen TH, Rodríguez-Gallego C, Soler-Palacin P, Colobran R, Tillmann V, Neven B, Trouillet-Assant S, Brodin P, Abel L, Jouanguy E, Zhang Q, Martinón-Torres F, Salas A, Gómez-Carballa A, Gonzalez-Granado LI, Kisand K, Okada S, Puel A, Cobat A, Casanova JL. Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children. J Exp Med 2024;221(2):e20231353.

Publications in 2023:

  1. Rosa Duque JS, Leung D, Yip KM, Lee DHL, So HK, Wong WHS, Lau YL. COVID-19 vaccines versus pediatric hospitalization. Cell Reports Medicine 2023;4(2):100936. IF14.3 [3]
  2. Tangye SG; COVID Human Genetic Effort consortium. Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity. Journal of Allergy and Clinical Immunology 2023; 151(4):818-831. IF14.2 [10]
  3. Rosa Duque JS, Wang X, Leung D, Cheng SMS, Cohen CA, Mu X, Hachim A, Zhang Y, Chan SM, Chaothai S, Kwan KKH, Chan KCK, Li JKC, Luk LLH, Tsang LCH, Wong WHS, Cheang CH, Hung TK, Lam JHY, Chua GT, Tso WWY, Ip P, Mori M, Kavian N, Leung WH, Valkenburg S, Peiris M, Tu W, Lau YL. Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents. Nature Communications 2022; 13(1):3700. IF16.6 [29]
  4. Chua GT, Lok Yan C, Wong WH, Sridhar S, To KK, Lau J, Gurung S, Mahtani S, Ho R, Li WS, Yam JC, Rosa Duque JS, Wong ICK, Lau YL, Kwan MYW, Ip P. COVID-19 vaccine acceptance and hesitancy among ethnic minorities in Hong Kong. Human Vaccines & Immunotherpeutics 2022;18(5):2054261. IF4.8 [2]
  5. Leung D, Mu X, Duque JSR, Cheng SMS, Wang M, Zhang W, Zhang Y, Tam IYS, Lee TSS, Lam JHY, Chan SM, Cheang CH, Chung Y, Wong HHW, Lee AMT, Li WY, Chaothai S, Tsang LCH, Chua GT, Cheong KN, Au EYL, Kwok JSY, Chan KW, Chong PCY, Lee PPW, Ho MHK, Lee TL, Tu W, Peiris M, Lau YL. Safety and immunogenicity of 3 doses of BNT162b2 and CoronaVac in children and adults with inborn errors of immunity. Frontiers in Immunology 2022;13:982155. IF7.3 [5]
  6. Mu X, Cohen CA, Leung D, Rosa Duque JS, Cheng SMS, Chung Y, Wong HHW, Lee AMT, Li WY, Tam IYS, Lam JHY, Lee DHL, Chan SM, Tsang LCH, Chan KCK, Li JKC, Luk LLH, Chaothai S, Kwan KKH, Chu NC, Mori M, Jeevan T, Kandeil A, Webby RJ, Tu W, Valkenburg SA, Peiris M, Lau YL. Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents. Signal Transduction and Targeted Therapy 2022; 7(1):397. IF39.3 [4]
  7. Yu MKL, Chan SHS, Cheng S, Leung D, Chan SM, Yan ASK, Wong WHS, Peiris M, Lau YL, Rosa Duque JS. Hesitancy, reactogenicity and immunogenicity of the mRNA and whole-virus inactivated Covid-19 vaccines in pediatric neuromuscular diseases. Human Vaccines & Immunotherpeutics 2023;19(1):2206278. IF0.77 [2]
  8. Lin TS, Lee JH, Wang LC, Yang YH, Lau YL, Lee WI, Lin YT, Chiang BL, Yu HH. Clinical features and outcomes of patients with chronic granulomatous disease in Taiwan. Journal of Microbiology, Immunology and Infection 2023;56(1):130-138. IF7.4 [2]
  9. Jindal AK, Chaudhary H, Tyagi R, Rawat A, Suri D, Patra PK, Arora K, Chawla S, Vyas S, Arora M, Aggarwal R, Basu S, Bansal R, Sachdeva MUS, Gupta A, Pandiarajan V, Sankhyan N, Suthar R, Sahu JK, Singh M, Mani R, Sharma R, Saka R, Imai K, Ohara O, Nonoyama S, Hammarström L, Chan KW, Lau YL, Singh S. Meningoencephalitis in primary antibody deficiency: Our experience from northwest India. Journal of Neuroimmunology 2022;371:577952. IF3.3
  10. Chau JFT, Lee M, Chui MMC, Yu MHC, Fung JLF, Mak CCY, Chau CS, Siu KK, Hung J, Yeung KS, Kwong AKY, O'Callaghan C, Lau YL, Lee CD, Chung BH, Lee SL. Functional evaluation and genetic landscape of children and young adults referred for assessment of bronchiectasis. Frontiers in Genetics 2022;13:933381. IF3.7 [1]
  11. Chua GT, Tsao S, Kwan MYW, Yu TC, Leung ASY, Li KW, Chow CCK, Ku WH, Kwok J, To KKW, Lau YL, Lai FTT, Wong ICK, Ip P. Medium-term outcomes of myocarditis and pericarditis following BNT162b2 vaccination among adolescents in Hong Kong. Emerging Microbes & Infections 2022;11(1):2466-2473. IF13.2 [4]
  12. Leung D, Rosa Duque JS, Yip KM, So HK, Wong WHS, Lau YL. Effectiveness of BNT162b2 and CoronaVac in children and adolescents against SARS-CoV-2 infection during Omicron BA.2 wave in Hong Kong. Communications Medicine (Lond) 2023;3(1):3.
  13. Dasanayake D, Bustamante J, Boisson-Dupuis S, Karunatilleke C, Thambyrajah J, Puel A, Chan KW, Doffinger R, Lau YL, Casanova JL, Kumararatne D, de Silva R. Inborn errors of immunity-the Sri Lankan experience 2010-2022. Journal of Clinical Immunology 2023; 43(8):1858-72. IF9.1
  14. Belaid B, Lamara Mahammed L, Drali O, Oussaid AM, Touri NS, Melzi S, Dehimi A, Berkani LM, Merah F, Larab Z, Allam I, Khemici O, Kirane SY, Boutaba M, Belbouab R, Bekkakcha H, Guedouar A, Chelali A, Baamara B, Noui D, Baaziz H, Rezak R, Azzouz SM, Aichaoui M, Moktefi A, Benhatchi RM, Oussalah M, Benaissa N, Laredj A, Bouchetara A, Adria A, Habireche B, Tounsi N, Dahmoun F, Touati R, Boucenna H, Bouferoua F, Sekfali L, Bouhafs N, Aboura R, Kherra S, Inouri Y, Dib S, Medouri N, Khelfaoui N, Redjedal A, Zelaci A, Yahiaoui S, Medjadj S, Touhami TK, Kadi A, Amireche F, Frada I, Houasnia S, Benarab K, Boubidi C, Ferhani Y, Benalioua H, Sokhal S, Benamar N, Aggoune S, Hadji K, Bellouti A, Rahmoune H, Boutrid N, Okka K, Ammour A, Saadoune H, Amroun M, Belhadj H, Ghanem A, Abbaz H, Boudrioua S, Zebiche B, Ayad A, Hamadache Z, Ouaras N, Achour N, Bouchair N, Boudiaf H, Bekkat-Berkani D, Maouche H, Bouzrar Z, Aissat L, Ibsaine O, Bioud B, Kedji L, Dahlouk D, Bensmina M, Radoui A, Bessahraoui M, Bensaadi N, Mekki A, Zeroual Z, Chan KW, Leung D, Tebaibia A, Ayoub S, Mekideche D, Gharnaout M, Casanova JL, Puel A, Lau YL, Cherif N, Ladj S, Smati L, Boukari R, Benhalla N, Djidjik R. Inborn errors of immunity in Algerian children and adults: A single-center experience over a period of 13 years (2008-2021). Frontiers in Immunology 2022;13:900091. IF7.3 [3]
  15. Yaakoubi R, Mekki N, Ben-Mustapha I, Ben-Khemis L, Bouaziz A, Ben Fraj I, Ammar J, Hamzaoui A, Turki H, Boussofara L, Denguezli M, Haddad S, Ouederni M, Bejaoui M, Chan KW, Lau YL, Mellouli F, Barbouche MR, Ben-Ali M. Diagnostic challenge in a series of eleven patients with hyper IgE syndromes. Frontiers in Immunology 2023;13:1057679. IF7.3
  16. Lee SL, Lau YL, Wong WH, Tian LW. Childhood wheeze, allergic rhinitis, and eczema in Hong Kong ISAAC Study from 1995 to 2015. International Journal of Environmental Ressearch and Public Health 2022;19(24):16503. IF4.6 [1]
  17. Cao Y, Ha SY, So CC, Tong MT, Tang CS, Zhang H, Liang R, Yang J, Chung BH, Chan GC, Lau YL, Garcia-Barcelo MM, Ma ES, Sucharitchan P, Hirankarn N, Yang W. NGS4THAL, a one-stop molecular diagnosis and carrier screening tool for thalassemia and other hemoglobinopathies by next-generation sequencing. Journal of Molecular Diagnostics 2022;24(10):1089-1099. IF4.1 [4]
  18. Ma W, Lau YL, Yang W, Wang YF. Random forests algorithm boosts genetic risk prediction of systemic lupus erythematosus. Frontiers in Genetics 2022;13:902793. IF3.7 [3]
  19. Wong WH, Leung D, Chua GT, Duque JSDR, Peare S, So HK, Chan SM, Kwan MY, Ip P, Lau YL. Survey data on the attitudes of adolescents in Hong Kong towards the COVID-19 vaccination. Data in Brief 2022;42:108069. IF1.2
  20. Hung TK, Leung D, Duque JSR, Lau YL. Bacillus Calmette-Guérin Scar erythema in a 14-year-old girl post-BNT162b2 vaccination. Pediatrics International 2022;64(1):e15090. IF1.4 [1]
  21. Wong WH, So HK, Rosa Duque JS, Tso WW, Chong PC, Kwan MY, Lau YL. Impact of a focus education in Zoom on COVID-19 vaccine hesitancy in Hong Kong parents of the preschoolers. Human Vaccination Immunotherapy 2022;18(5):2081460. IF4.8 [2]
  22. Deng M, Li Y, Li Y, Mao X, Ke H, Liang W, Lei X, Lau YL, Mao H. A novel STAT3 gain-of-function mutation in fatal infancy-onset interstitial lung disease. Frontiers in Immunology 2022;13:866638. IF7.3 [1]
  23. Chung MH, Chua GT, Leung D, Chan KW, Nicholls J, Lau YL. Fatal SARS in X-linked lymphoproliferative disease Type 1: A case report. Frontiers in Pediatrics 2022;10:794110. IF7.3 [1]
  24. Chan KW, Wong CY, Leung D, Yang X, Fok SFS, Mak PHS, Yao L, Ma W, Mao H, Zhao X, Liang W, Singh S, Barbouche MR, He JX, Jiang LP, Liew WK, Le MHT, Muktiarti D, Santos-Ocampo FJ, Djidjik R, Belaid B, Ismail IH, Abdul Latiff AH, Lee WS, Chen TX, Liu J, Jin R, Wang X, Chien YH, Yu HH, Raj D, Raj R, Vaughan J, Urban M, van den Berg S, Eley B, Lee AC, Isa MS, Ang EY, Lee BW, Yeoh AEJ, Shek LP, Quynh Le NN, Nguyen VAT, Phan Nguyen Lien A, Capulong RD, Mallillin JM, Villanueva JCMM, Camonayan KAB, Vera M, Casis-Hao RJ, Lobo RCM, Foronda R, Binas VWE, Boushaki S, Kechout N, Phongsamart G, Wongwaree S, Jiratchaya C, Lao-Araya M, Trakultivakorn M, Suratannon N, Jirapongsananuruk O, Chantveerawong T, Kamchaisatian W, Chan LL, Koh MT, Wong KJ, Fong SM, Thong MK, Latiff ZA, Noh LM, de Silva R, Jouhadi Z, Al-Saad K, Vignesh P, Jindal AK, Rawat A, Gupta A, Suri D, Yang J, Au EY, Kwok JS, Chan SY, Hui WY, Chua GT, Duque JR, Cheong KN, Chong PCY, Ho MHK, Lee TL, Wong WH, Yang W, Lee PP, Tu W, Yang XQ, Lau YL. Targeted gene sanger sequencing should remain the first-tier genetic test for children suspected to have the five common X-Linked inborn errors of immunity. Frontiers in Immunology 2022;13:883446. IF7.3 [2]
  25. Rawat A, Sharma M, Vignesh P, Jindal AK, Suri D, Das J, Joshi V, Tyagi R, Sharma J, Kaur G, Lau YL, Imai K, Nonoyama S, Lenardo M, Singh S. Utility of targeted next generation sequencing for inborn errors of immunity at a tertiary care centre in North India. Scientific Reports 2022;12(1):10416. IF4.6 [4]
  26. Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X; CoV-Contact Cohort§; COVID Human Genetic Effort¶; Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard CL, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL. Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. Science 2023;379(6632):eabo3627. IF56.9
  27. Sharma M, Leung D, Momenilandi M, Jones LCW, Pacillo L, James AE, Murrell JR, Delafontaine S, Maimaris J, Vaseghi-Shanjani M, Del Bel KL, Lu HY, Chua GT, Di Cesare S, Fornes O, Liu Z, Di Matteo G, Fu MP, Amodio D, Tam IYS, Chan GSW, Sharma AA, Dalmann J, van der Lee R, Blanchard-Rohner G, Lin S, Philippot Q, Richmond PA, Lee JJ, Matthews A, Seear M, Turvey AK, Philips RL, Brown-Whitehorn TF, Gray CJ, Izumi K, Treat JR, Wood KH, Lack J, Khleborodova A, Niemela JE, Yang X, Liang R, Kui L, Wong CSM, Poon GWK, Hoischen A, van der Made CI, Yang J, Chan KW, Rosa Duque JSD, Lee PPW, Ho MHK, Chung BHY, Le HTM, Yang W, Rohani P, Fouladvand A, Rokni-Zadeh H, Changi-Ashtiani M, Miryounesi M, Puel A, Shahrooei M, Finocchi A, Rossi P, Rivalta B, Cifaldi C, Novelli A, Passarelli C, Arasi S, Bullens D, Sauer K, Claeys T, Biggs CM, Morris EC, Rosenzweig SD, O'Shea JJ, Wasserman WW, Bedford HM, van Karnebeek CDM, Palma P, Burns SO, Meyts I, Casanova JL, Lyons JJ, Parvaneh N, Nguyen ATV, Cancrini C, Heimall J, Ahmed H, McKinnon ML, Lau YL, Béziat V, Turvey SE. Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease. Journal of Experimental Medicine 2023;220(5):e20221755. IF15.3 [16]
  28. Matuozzo D, Talouarn E, Marchal A, Zhang P, Manry J, Seeleuthner Y, Zhang Y, Bolze A, Chaldebas M, Milisavljevic B, Gervais A, Bastard P, Asano T, Bizien L, Barzaghi F, Abolhassani H, Abou Tayoun A, Aiuti A, Alavi Darazam I, Allende LM, Alonso-Arias R, Arias AA, Aytekin G, Bergman P, Bondesan S, Bryceson YT, Bustos IG, Cabrera-Marante O, Carcel S, Carrera P, Casari G, Chaïbi K, Colobran R, Condino-Neto A, Covill LE, Delmonte OM, El Zein L, Flores C, Gregersen PK, Gut M, Haerynck F, Halwani R, Hancerli S, Hammarström L, Hatipoğlu N, Karbuz A, Keles S, Kyheng C, Leon-Lopez R, Franco JL, Mansouri D, Martinez-Picado J, Metin Akcan O, Migeotte I, Morange PE, Morelle G, Martin-Nalda A, Novelli G, Novelli A, Ozcelik T, Palabiyik F, Pan-Hammarström Q, de Diego RP, Planas-Serra L, Pleguezuelo DE, Prando C, Pujol A, Reyes LF, Rivière JG, Rodriguez-Gallego C, Rojas J, Rovere-Querini P, Schlüter A, Shahrooei M, Sobh A, Soler-Palacin P, Tandjaoui-Lambiotte Y, Tipu I, Tresoldi C, Troya J, van de Beek D, Zatz M, Zawadzki P, Al-Muhsen SZ, Alosaimi MF, Alsohime FM, Baris-Feldman H, Butte MJ, Constantinescu SN, Cooper MA, Dalgard CL, Fellay J, Heath JR, Lau YL, Lifton RP, Maniatis T, Mogensen TH, von Bernuth H, Lermine A, Vidaud M, Boland A, Deleuze JF, Nussbaum R, Kahn-Kirby A, Mentre F, Tubiana S, Gorochov G, Tubach F, Hausfater P; COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians; COVID Clinicians; Orchestra Working Group; Amsterdam UMC Covid-19 Biobank; NIAID-USUHS COVID Study Group; Meyts I, Zhang SY, Puel A, Notarangelo LD, Boisson-Dupuis S, Su HC, Boisson B, Jouanguy LDE, Casanova JL, Zhang Q, Abel L, Cobat A. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Medicine 2023;15(1):22. IF12.3 [12]
  29. García-García A, Pérez de Diego R, Flores C, Rinchai D, Solé-Violán J, Deyà-Martínez À, García-Solis B, Lorenzo-Salazar JM, Hernández-Brito E, Lanz AL, Moens L, Bucciol G, Almuqamam M, Domachowske JB, Colino E, Santos-Perez JL, Marco FM, Pignata C, Bousfiha A, Turvey SE, Bauer S, Haerynck F, Ocejo-Vinyals JG, Lendinez F, Prader S, Naumann-Bartsch N, Pachlopnik Schmid J, Biggs CM, Hildebrand K, Dreesman A, Cárdenes MÁ, Ailal F, Benhsaien I, Giardino G, Molina-Fuentes A, Fortuny C, Madhavarapu S, Conway DH, Prando C, Schidlowski L, Martínez de Saavedra Álvarez MT, Alfaro R, Rodríguez de Castro F; ESID Registry Working Party; COVID Human Genetic Effort; Meyts I, Hauck F, Puel A, Bastard P, Boisson B, Jouanguy E, Abel L, Cobat A, Zhang Q, Casanova JL, Alsina L, Rodríguez-Gallego C. Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia. Journal of Experimental Medicine 2023;220(5):e20220170. IF15.3
  30. Channon-Wells S, Vito O, McArdle AJ, Seaby EG, Patel H, Shah P, Pazukhina E, Wilson C, Broderick C, D'Souza G, Keren I, Nijman RG, Tremoulet A, Munblit D, Ulloa-Gutierrez R, Carter MJ, Ramnarayan P, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Blyuss O, Levin M; Best Available Treatment Study (BATS) consortium. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study. Lancet Rheumatology 2023;5(4):e184-e199. IF25.4 [3]
  31. Rosa Duque JS, Leung D, Yip KM, Lee DHL, So HK, Wong WHS, Lau YL. COVID-19 vaccines versus pediatric hospitalization. Cell Reports Medicine 2023;4(2):100936. IF14.3 [3]
  32. Tangye SG; COVID Human Genetic Effort consortium. Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity. Journal of Allergy and Clinical Immunology 2023;151(4):818-831. IF14.2 [10]
  33. Bucciol G; COVID Human Genetic Effort; Meyts I. Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children. Journal of Allergy and Clinical Immunology 2023;151(4):832-840. IF14.2 [3]
  34. Lin TS, Lee JH, Wang LC, Yang YH, Lau YL, Lee WI, Lin YT, Chiang BL, Yu HH. Clinical features and outcomes of patients with chronic granulomatous disease in Taiwan. Journal of Microbiology, Immunology and Infection 2023;56(1):130-138. IF7.4 [2]
  35. Chan SCW, Wang YF, Yap DYH, Chan TM, Lau YL, Lee PPW, Lai WM, Ying SKY, Tse NKC, Leung AMH, Mok CC, Lee KL, Li TWL, Tsang HHL, Yeung WWY, Ho CTK, Wong RWS, Yang W, Lau CS, Li PH. Risk and Factors associated with disease manifestations in systemic lupus erythematosus - lupus nephritis (RIFLE-LN): a ten-year risk prediction strategy derived from a cohort of 1652 patients. Frontiers in Immunology 2023;14:1200732. IF7.3
  36. Tso WW, Kwan MY, Kwok JS, Tsang JO, Yip CC, Leung LK, Li C, Wang Y, Chow MS, Tsang AM, Chim S, Chow CY, Ho AC, Chan SH, Tai SM, Lee WC, Chan VC, Yau EK, Sun JK, Chow HM, Lau YL, Ip P, Chan JF. Clinical characteristics of unvaccinated or incompletely vaccinated children with neurological manifestations due to SARS-CoV-2 Omicron infection. Journal of Medical Virology 2023;95(7):e28895. IF12.7 [1]
  37. Leung D, Cohen CA, Mu X, Rosa Duque JS, Cheng SMS, Wang X, Wang M, Zhang W, Zhang Y, Tam IYS, Lam JHY, Chan SM, Chaothai S, Kwan KKH, Chan KCK, Li JKC, Luk LLH, Tsang LCH, Chu NC, Wong WHS, Mori M, Leung WH, Valkenburg S, Peiris M, Tu W, Lau YL. Immunogenicity against wild-type and Omicron SARS-CoV-2 after a third dose of inactivated COVID-19 vaccine in healthy adolescents. Frontiers in Immunology 2023;14:1106837. IF7.3 [7]
  38. Greybe L, Leung D, Wieselthaler N, le Roux DM, Chan KW, Lau YL, Eley B. A rare mutation causing autosomal dominant STAT1 deficiency in a South African multiplex kindred with disseminated BCG infection. BMC Pediatrics 2023;23(1):378. IF 2.4
  39. Chan EYH, Leung D, Cheng SMS, Rosa Duque JS, Mu X, Ho FTW, Tong PC, Lai WM, Lee MHL, Chim S, Tam IYS, Tsang LCH, Kwan KKH, Chung Y, Wong HHW, Lee AMT, Li WY, Sze STK, Lam JHY, Lee DHL, Chan SM, Tu WW, Peiris M, Ma ALT, Lau YL. Humoral and cellular immunogenicity and safety of 3-dose inactivated COVID-19 vaccine in young children less than 5 years with kidney diseases. Kidney International Reports 2023; 8(11):2356-67. IF6
  40. Leung D, Chan EYH, Mu X, Rosa Duque JS, Cheng SMS, Ho FTW, Tong PC, Lai WM, Lee MHL, Chim S, Tam IYS, Tsang LCH, Kwan KKH, Chung Y, Wong HHW, Lee AMT, Li WY, Sze STK, Lam JHY, Lee DHL, Chan SM, Tu WW, Peiris M, Ma ALT, Lau YL. Humoral and cellular immunogenicity of 3 doses of BNT162b2 in children with kidney diseases. Kidney International Reports 2023; doi: ttps://doi.org/10.1016/j.ekir.2023.08.014. IF6
  41. International League Against Epilepsy Consortium on Complex Epilepsies. GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nature Genetics 2023;55(9):1471-1482.
  42. Le Voyer T, Parent AV, Liu X, Cederholm A, Gervais A, Rosain J, Nguyen T, Perez Lorenzo M, Rackaityte E, Rinchai D, Zhang P, Bizien L, Hancioglu G, Ghillani-Dalbin P, Charuel JL, Philippot Q, Gueye MS, Maglorius Renkilaraj MRL, Ogishi M, Soudée C, Migaud M, Rozenberg F, Momenilandi M, Riller Q, Imberti L, Delmonte OM, Müller G, Keller B, Orrego J, Franco Gallego WA, Rubin T, Emiroglu M, Parvaneh N, Eriksson D, Aranda-Guillen M, Berrios DI, Vong L, Katelaris CH, Mustillo P, Raedler J, Bohlen J, Bengi Celik J, Astudillo C, Winter S; NF-κB Consortium; COVID Human Genetic Effort; McLean C, Guffroy A, DeRisi JL, Yu D, Miller C, Feng Y, Guichard A, Béziat V, Bustamante J, Pan-Hammarström Q, Zhang Y, Rosen LB, Holland SM, Bosticardo M, Kenney H, Castagnoli R, Slade CA, Boztuğ K, Mahlaoui N, Latour S, Abraham RS, Lougaris V, Hauck F, Sediva A, Atschekzei F, Sogkas G, Poli MC, Slatter MA, Palterer B, Keller MD, Pinzon-Charry A, Sullivan A, Droney L, Suan D, Wong M, Kane A, Hu H, Ma C, Grombiříková H, Ciznar P, Dalal I, Aladjidi N, Hie M, Lazaro E, Franco J, Keles S, Malphettes M, Pasquet M, Maccari ME, Meinhardt A, Ikinciogullari A, Shahrooei M, Celmeli F, Frosk P, Goodnow CC, Gray PE, Belot A, Kuehn HS, Rosenzweig SD, Miyara M, Licciardi F, Servettaz A, Barlogis V, Le Guenno G, Herrmann VM, Kuijpers T, Ducoux G, Sarrot-Reynauld F, Schuetz C, Cunningham-Rundles C, Rieux-Laucat F, Tangye SG, Sobacchi C, Doffinger R, Warnatz K, Grimbacher B, Fieschi C, Berteloot L, Bryant VL, Assant ST, Su H, Neven B, Abel L, Zhang Q, Boisson B, Cobat A, Jouanguy E, Kampe O, Bastard P, Roifman CM, Landegren N, Notarangelo LD, Anderson MS, Jean-Laurent Casanova, Puel A. Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency. Nature 2023;623(7988):803-813.
  43. Lau YL, Gennery A. Editorial on “Emerging talents in primary immunodeficiencies: 2022”. Frontiers in Immunology 2023;14:1267778.
  44. Shu Z, Zhang Y, Han T, Li Y, Piao Y, Sun F, Ma J, Mo W, Sun J, Chan KW, Yang W, Lau YL, Mao H. The genetic and clinical characteristics and effects of Canakinumab on cryopyrin-associated periodic syndrome: a large pediatric cohort study from China. Frontiers in Immunology 2023:14:1267933.
  45. Rosa Duque JS, Cheng SMS, Cohen CA, Leung D, Wang X, Mu X, Chung Y, Lau TM, Wang M, Zhang W, Zhang Y, Wong HHW, Tsang LCH, Chaothai S, Kwan TC, Li JKC, Chan KCK, Luk LLH, Ho JCH, Li WY, Lee AMT, Lam JHY, Chan SM, Wong WHS, Tam IYS, Mori M, Valkenburg SA, Peiris M, Tu W, Lau YL. Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents. World Journal of Pediatrics 2023. doi: 10.1007/s12519-023-00764-0.
  46. Wang X, Zhang Y, Chung Y, Tu CR, Zhang W, Mu X, Wang M, Chan GC, Leung WH, Lau YL, Liu Y, Tu W. Tumor vaccine based on extracellular vesicles derived from γδ-T cells exerts dual antitumor activities. Journal of Extracelluar Vesicles 2023;12(9):e12360.
  47. Liu Z, Shao L, Hou F, Li W, Wang YF, Feng H, Wang FQ, Lei Y, Zheng L, Liang R, Li J, Guo X, Zhang L, Zhang Y, Yang J, Qin X, Wei W, Yang X, Dang X, Ma W, She CH, Kong Q, Yang J, Ban B, Lau YL, Song Q, Yang W. Transcriptomic features of systemic lupus erythematosus patients in flare and changes during acute in-hospital treatment. Rheumatology (Oxford) 2023 Dec 23:kead704.

Publications in 2022:

  1. Wong WHS, Leung D, Chua GT, Duque JSR, Peare S, So HK, Chan SM, Kwan MYW, Ip P, Lau YL. Adolescents' attitudes to the COVID-19 vaccination. Vaccine 2022;40(7):967-969. IF5.5 [29]
  2. Li X, Lai FTT, Chua GT, Kwan MYW, Lau YL, Ip P, Wong ICK. Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong. JAMA Pediatrics 2022;176(6):612-614. IF26.1 [54]
  3. Lau YL, Fan Leung T, Sirvan Cetin B, Cagri Dinleyici E, Huang LM, Halperin SA, Hsiao CC, Tapiero B, Tipton M, Campbell JD, Moerman L, Povey M, Bi D, Singh T; Rota-096 study group. Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. Vaccine 2022 Mar 25;40(14):2184-2190. IF5.5 [3]
  4. Chiu TL, Leung D, Chan KW, Yeung HM, Wong CY, Mao H, He J, Vignesh P, Liang W, Liew WK, Jiang LP, Chen TX, Chen XY, Tao YB, Xu YB, Yu HH, Terblanche A, Lung DC, Li CR, Chen J, Tian M, Eley B, Yang X, Yang J, Chiang WC, Lee BW, Suri D, Rawat A, Gupta A, Singh S, Wong WHS, Chua GT, Duque JSDR, Cheong KN, Chong PC, Ho MH, Lee TL, Yang W, Lee PP, Lau YL. Phenomic Analysis of Chronic Granulomatous Disease Reveals More Severe Integumentary Infections in X-Linked Compared With Autosomal Recessive Chronic Granulomatous Disease. Frontiers in Immunology 2022;12:803763. IF7.3 [3]
  5. Rosa Duque JS, Leung D, Au EYL, Lau YL. Second dose of COVID-19 vaccination in immediate reactions to the first BNT162b2. Pediatric Allergy and Immunology 2022;33(1):e13683. IF4.4
  6. Wong WH, Leung D, Chua GT, Duque JSDR, Peare S, So HK, Chan SM, Kwan MY, Ip P, Lau YL. Survey data on the attitudes of adolescents in Hong Kong towards the COVID-19 vaccination. Data in Brief 2022;42:108069. IF1.2
  7. Wang X, Zhang Y, Mu X, Tu CR, Chung Y, Tsao SW, Chan GC, Leung WH, Lau YL, Liu Y, Tu W. Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment. Journal of ImmunoTherapy in Cancer 2022;10(2):e003832.
  8. Hung TK, Leung D, Duque JSR, Lau YL. Bacillus Calmette-Guérin Scar erythema in a 14-year-old girl post-BNT162b2 vaccination. Pediatrics International 2022;64(1):e15090. IF1.4
  9. Chau JFT, Yu MHC, Chui MMC, Yeung CCW, Kwok AWC, Zhuang X, Lee R, Fung JLF, Lee M, Mak CCY, Ng NYT, Chung CCY, Chan MCY, Tsang MHY, Chan JCK, Chan KYK, Kan ASY, Chung PHY, Yang W, Lee SL, Chan GCF, Tam PKH, Lau YL, Yeung KS, Chung BHY, Tang CSM. Comprehensive analysis of recessive carrier status using exome and genome sequencing data in 1543 Southern Chinese. NPJ Genomic Medicine 2022;7(1):23. IF5.3 [3]
  10. Ma AL, Leung D, Chan EY, Chim S, Cheng S, Ho FT, Lai WM, Tong PC, Lee MH, Wong WH, Chan SM, Rosa Duque J, Peiris JSM, Lau YL. Antibody responses to 2 doses of mRNA COVID-19 vaccine in pediatric patients with kidney diseases. Kidney International 2022;101(5):1069-1072. IF19.6 [9]
  11. Wong WH, Peare S, Lam HY, Chow CB, Lau YL. The estimated age-group specific influenza vaccine coverage rates in Hong Kong and the impact of the school outreach vaccination program. Human Vaccines and Immunotherapy 2022;18(1):1-5. IF4.8 [3]
  12. Tso WWY, Kwan MYW, Wang YL, Leung LK, Leung D, Chua GT, Ip P, Fong DYT, Wong WHS, Chan SHS, Chan JFW, Peiris M, Lau YL, Rosa Duque JS. Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections. Emerging Microbes & Infections 2022;11(1):1742-1750. IF13.2
  13. Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Koido M, Ha E, Liu L, Sakamoto Y, Jo S, Leng RX, Otomo N, Kwon YC, Sheng Y, Sugano N, Hwang MY, Li W, Mukai M, Yoon K, Cai M, Ishigaki K, Chung WT, Huang H, Takahashi D, Lee SS, Wang M, Karino K, Shim SC, Zheng X, Miyamura T, Kang YM, Ye D, Nakamura J, Suh CH, Tang Y, Motomura G, Park YB, Ding H, Kuroda T, Choe JY, Li C, Niiro H, Park Y, Shen C, Miyamoto T, Ahn GY, Fei W, Takeuchi T, Shin JM, Li K, Kawaguchi Y, Lee YK, Wang YF, Amano K, Park DJ, Yang W, Tada Y, Lau YL, Yamaji K, Zhu Z, Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi Y; Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Yamamoto K, Ohmura K, Kim TH, Yang S, Yamamoto T, Kim BJ, Shen N, Ikegawa S, Lee HS, Zhang X, Terao C, Cui Y, Bae SC. Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study. Annals of Rheumatic Diseases 2022;annrheumdis-2022-222345. IF27.4
  14. Brodin P, Casari G, Townsend L, O'Farrelly C, Tancevski I, Löffler-Ragg J, Mogensen TH, Casanova JL & The COVID Human Genetic Effort. Studying severe long COVID to understand post-infectious disorders beyond COVID-19. Nature Medicine 2022; 28: 879-882. IF82.9 [73]
  15. Rosa Duque JS, Wang X, Leung D, Cheng SMS, Cohen CA, Mu X, Hachim A, Zhang Y, Chan SM, Chaothai S, Kwan KKH, Chan KCK, Li JKC, Luk LLH, Tsang LCH, Wong WHS, Cheang CH, Hung TK, Lam JHY, Chua GT, Tso WWY, Ip P, Mori M, Kavian N, Leung WH, Valkenburg S, Peiris M, Tu W, Lau YL. Immunogenicity and reactogenicity of SARS-CoV-2 mRNA and inactivated vaccines in healthy adolescents. Nature Communications 2022; 3700. doi 10.21203/rs.3.rs-1327020/v1. IF16.6 [5]
  16. Andreakos E, Abel L, Vinh DC, Kaja E, Drolet BA, Zhang Q, O'Farrelly C, Novelli G, Rodríguez-Gallego C, Haerynck F, Prando C, Pujol A; COVID Human Genetic Effort, Su HC, Casanova JL, Spaan AN. A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. Nature Immunology 2022;23(2):159-164. IF30.5 [45]
  17. Zhang Q, Bastard P; COVID Human Genetic Effort, Cobat A, Casanova JL. Human genetic and immunological determinants of critical COVID-19 pneumonia. Nature 2022; 603(7902):587-598. IF64.8 [162]
  18. Mu X, Xiang Z, Xu Y, He J, Lu J, Chen Y, Wang X, Tu CR, Zhang Y, Zhang W, Yin Z, Leung WH, Lau YL, Liu Y, Tu W. Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes. Cellular and Molecular Immunology 2022;19(8):944-956. IF24.1 [4]
  19. Geier CB, Ellison M, Cruz R, Pawar S, Leiss-Piller A, Zmajkovicova K, McNulty SM, Yilmaz M, Evans MO 2nd, Gordon S, Ujhazi B, Wiest I, Abolhassani H, Aghamohammadi A, Barmettler S, Bhar S, Bondarenko A, Bolyard AA, Buchbinder D, Cada M, Cavieres M, Connelly JA, Dale DC, Deordieva E, Dorsey MJ, Drysdale SB, Ehl S, Elfeky R, Fioredda F, Firkin F, Förster-Waldl E, Geng B, Goda V, Gonzalez-Granado L, Grunebaum E, Grzesk E, Henrickson SE, Hilfanova A, Hiwatari M, Imai C, Ip W, Jyonouchi S, Kanegane H, Kawahara Y, Khojah AM, Kim VH, Kojić M, Kołtan S, Krivan G, Langguth D, Lau YL, Leung D, Miano M, Mersyanova I, Mousallem T, Muskat M, Naoum FA, Noronha SA, Ouederni M, Ozono S, Richmond GW, Sakovich I, Salzer U, Schuetz C, Seeborg FO, Sharapova SO, Sockel K, Volokha A, von Bonin M, Warnatz K, Wegehaupt O, Weinberg GA, Wong KJ, Worth A, Yu H, Zharankova Y, Zhao X, Devlin L, Badarau A, Csomos K, Keszei M, Pereira J, Taveras AG, Beaussant-Cohen SL, Ong MS, Shcherbina A, Walter JE. Disease Progression of WHIM syndrome in an international cohort of 66 pediatric and adult patients. Journal of Clinical Immunology 2022; 42(8):1748-1765. IF9.1 [5]

Publications in 2021:

  1. Vignesh P, Loganathan SK, Sudhakar M, Chaudhary H, Rawat A, Sharma M, Shekar A, Vaiphei K, Kumar N, Singh Sachdeva MU, Jindal AK, Suri D, Gupta A, Ray P, Imai K, Ohara O, Nonoyama S, Lau YL, Singh S. Hemophagocytic Lymphohistiocytosis in Children with Chronic Granulomatous Disease-Single-Center Experience from North India. Journal of Allergy and Clinical Immunology In Practice 2021;9(2):771-782.e3. IF9.4 [8]
  2. Suri D, Rikhi R, Jindal AK, Rawat A, Sudhakar M, Vignesh P, Gupta A, Kaur A, Sharma J, Ahluwalia J, Bhatia P, Khadwal A, Raj R, Uppuluri R, Desai M, Taur P, Pandrowala AA, Gowri V, Madkaikar MR, Lashkari HP, Bhattad S, Kumar H, Verma S, Imai K, Nonoyama S, Ohara O, Chan KW, Lee PP, Lau YL, Singh S. Wiskott Aldrich Syndrome: A Multi-Institutional Experience From India. Frontiers in Immunology 2021;12:627651. IF7.3 [13]
  3. Rawat A, Jindal AK, Suri D, Vignesh P, Gupta A, Saikia B, Minz RW, Banday AZ, Tyagi R, Arora K, Joshi V, Mondal S, Shandilya JK, Sharma M, Desai M, Taur P, Pandrowala A, Gowri V, Sawant-Desai S, Gupta M, Dalvi AD, Madkaikar M, Aggarwal A, Raj R, Uppuluri R, Bhattad S, Jayaram A, Lashkari HP, Rajasekhar L, Munirathnam D, Kalra M, Shukla A, Saka R, Sharma R, Garg R, Imai K, Nonoyama S, Ohara O, Lee PP, Chan KW, Lau YL, Singh S. Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India. Frontiers in Immunology 2021;11:612323. IF7.3 [19]
  4. Chua GT, Wong JSC, To KKW, Lam ICS, Yau FYS, Chan WH, Ho PPK, Duque JSR, Yip CCY, Ng ACK, Wong WHS, Kwong JHY, Leung KFS, Wan PT, Lam K, Wong ICK, Kwok J, Ho MHK, Chan GCF, Lau YL, Ip P, Kwan MYW. Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019. Emerging Microbes & Infections 2021;10(1):235-241. IF13.2 [24]
  5. Chua GT, Rosa Duque JS, Cheuk DKL, Leung AWK, Wong WHS, Liu APY, Lee PPW, Ha SY, Chiang AKS, Ho MHK, Chu WK, Chan YS, Luk CW, Ling ASC, Kwan MYW, Yiu OKF, Wong ICK, Lau YL, Li CK, Leung WH, Chan GCF, Ip P, Kwok J. HLA alleles associated with asparaginase hypersensitivity in Chinese children. Journal of Hematology and Oncology 2021;14(1):182. IF28.5 [2]
  6. Chua GT, Wong JSC, Lam I, Ho PPK, Chan WH, Yau FYS, Rosa Duque JS, Ho ACC, Siu KK, Cheung TWY, Lam DSY, Chan VCM, Lee KP, Tsui KW, Wong TW, Yau MM, Yau TY, Chan KCC, Yu MWL, Chow CK, Chiu WK, Chan KC, Wong WHS, Ho MHK, Tso WWY, Tung KTS, Wong CS, Kwok J, Leung WH, Yam JC, Wong ICK, Tam PKH, Chan GCF, Chow CB, To KKW, Lau YL, Yuen KY, Ip P, Kwan MYW. Clinical characteristics and transmission of COVID-19 in children and youths during 3 waves of outbreaks in Hong Kong. JAMA Network Open 2021;4(5):e218824. IF13.8 [68]
  7. Rawat A, Vignesh P, Sudhakar M, Sharma M, Suri D, Jindal A, Gupta A, Shandilya JK, Loganathan SK, Kaur G, Chawla S, Patra PK, Khadwal A, Saikia B, Minz RW, Aggarwal V, Taur P, Pandrowala A, Gowri V, Desai M, Kulkarni M, Hule G, Bargir U, Kambli P, Madkaikar M, Bhattad S, Ginigeri C, Kumar H, Jayaram A, Munirathnam D, Sivasankaran M, Raj R, Uppuluri R, Na F, George B, Lashkari HP, Kalra M, Sachdeva A, Seth S, Sabui T, Gupta A, van Leeuwen K, de Boer M, Chan KW, Imai K, Ohara O, Nonoyama S, Lau YL, Singh S. Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients from India. Frontiers in Immunology 2021;12:625320. IF7.3 [26]
  8. Yeung TW, Cheong KN, Lau YL, Tse KN. Adolescent-onset anti-MDA5 antibody-positive juvenile dermatomyositis with rapidly progressive interstitial lung disease and spontaneous pneumomediastinum: a case report and literature review. Pediatric Rheumatology 2021;19(1):103. IF2.5 [10]
  9. Vignesh P, Rawat A, Kumrah R, Singh A, Gummadi A, Sharma M, Kaur A, Nameirakpam J, Jindal A, Suri D, Gupta A, Khadwal A, Saikia B, Minz RW, Sharma K, Desai M, Taur P, Gowri V, Pandrowala A, Dalvi A, Jodhawat N, Kambli P, Madkaikar MR, Bhattad S, Ramprakash S, Cp R, Jayaram A, Sivasankaran M, Munirathnam D, Balaji S, Rajendran A, Aggarwal A, Singh K, Na F, George B, Mehta A, Lashkari HP, Uppuluri R, Raj R, Bartakke S, Gupta K, Sreedharanunni S, Ogura Y, Kato T, Imai K, Chan KW, Leung D, Ohara O, Nonoyama S, Hershfield M, Lau YL, Singh S. Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India. Frontiers in Immunology 2021;11:619146. IF7.3 [27]
  10. Ma HY, Chan JFY, Tan YP, Kui L, Tsang CC, Pei SLC, Lau YL, Woo PCY, Lee PPW. NLRP3 Inflammasome Contributes to Host Defense Against Talaromyces marneffei Infection. Frontiers in Immunology 2021;12:760095. IF7.3 [7]
  11. Meyts I, Bousfiha A, Duff C, Singh S, Lau YL, Condino-Neto A, Bezrodnik L, Ali A, Adeli M, Drabwell J. Primary immunodeficiencies: a decade of progress and a promising future. Frontiers in Immunology 2021;11:625753. IF7.3 [27]
  12. Zhong Y, Huang CH, Soe WM, Chan KW, Isa MS, Soh J, Yap M, MacAry PA, Lau YL, Chai LYA, Shek LP, Lee BW. A Novel X-Linked Inhibitor of Apoptosis Deficient Variant Showing Attenuated Epstein-Barr Virus Response. Journal of Pediatric Infectious Diseases Society 2021;10(3):345-348. [3]
  13. Zheng J, Wen L, Yen HL, Liu M, Liu Y, Teng O, Wu WF, Ni K, Lam KT, Huang C, Yang J, Lau YL, Perlman S, Peiris M, Tu W. Phenotypic and Functional Characteristics of a Novel Influenza Virus Hemagglutinin-Specific Memory NK Cell. Journal of Virology 2021;95(12):e00165-21. IF5.4 [4]
  14. Yu MHC, Mak CCY, Fung JLF, Lee M, Tsang MHY, Chau JFT, Chung PH, Yang W, Chan GCF, Lee SL, Lau YL, Tam PKH, Tang CSM, Yeung KS, Chung BHY. Actionable secondary findings in 1116 Hong Kong Chinese based on exome sequencing data. Journal of Human Genetics 2021;66(6):637-641. IF3.5 [3]
  15. Chua GT, Chong PC, Au EY, Cheong KN, Wong WH, Chan EY, Ho MH, Lau YL, Duque JSR. Skin prick testing a better predictor than blood testing for the diagnosis of peanut allergy in Chinese children. Asian Pacific Journal of Allergy and Immunology 2021; 39(4):241-248. IF5 [2]
  16. Chua GT, Kwan MYW, Chui CSL, Smith RD, Cheung EC, Tian T, Leung MTY, Tsao SSL, Kan E, Ng WKC, Man Chan VC, Tai SM, Yu TC, Lee KP, Wong JSC, Lin YK, Shek CC, Leung ASY, Chow CK, Li KW, Ma J, Fung WY, Lee D, Ng MY, Wong WHS, Tsang HW, Kwok J, Leung D, Chung KL, Chow CB, Chan GCF, Leung WH, To KKW, Yuen KY, Lau YL, Wong ICK, Ip P. Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination. Clinical Infectious Diseases 2021;ciab989. IF11.8 [107]
  17. Wong CH, Duque JSR, Wong JSC, Chan CV, Lam ICS, Fu YM, Cheong KN, Chua GT, Lee PP, Ip P, Ho MHK, Wong ICK, Chan GC, Leung WH, Lee SL, Lee KP, Chiu SC, Wong MSR, Wong MSC, Lau YL, Kwan MY. Epidemiology and Trends of Infective Meningitis in Neonates and Infants Less than 3 Months of Age in Hong Kong. Internation Journal of Infectious Diseases 2021;S1201-9712(21)00514-2. IF8.4 [3]
  18. Zhou D, Rudnicki M, Chua GT, Lawrance SK, Zhou B, Drew JL, Barbar-Smiley F, Armstrong TK, Hilt ME, Birmingham DJ, Passler W, Auletta JJ, Bowden SA, Hoffman RP, Wu YL, Jarjour WN, Mok CC, Ardoin SP, Lau YL, Yu CY. Human complement C4B allotypes and deficiencies in selected cases with autoimmune diseases. Frontiers in Immunology 2021;12:739430. IF7.3 [6]
  19. Song Q, Lei Y, Shao L, Li W, Kong Q, Lin Z, Qin X, Wei W, Hou F, Li J, Guo X, Mao Y, Cao Y, Liu Z, Zheng L, Liang R, Jiang Y, Liu Y, Zhang L, Yang J, Lau YL, Zhang Y, Ban B, Wang YF, Yang Y. Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus. Rheumatology 2021; 60(9):4407-4417. IF5.5 [14]
  20. Wang YF, Wei W, Tangtanatakul P, Zheng L, Lei Y, Lin Z, Qian C, Qin X, Hou F, Zhang X, Shao L, Satproedprai N, Mahasirimongkol S, Pisitkun P, Song Q, Lau YL, Zhang Y, Hirankarn N, Yang W. Identification of shared and Asian-specific loci for systemic lupus erythematosus and evidence for roles of Type III interferon signaling and lysosomal function in the disease: A multi-ancestral genome-wide association study. Arthritis & Rheumatology 2022;74(5):840-848. IF13.3 [12]
  21. Zhang YM, Zhou XJ, Wang YN, Liu XZ, Wang YF, Lau YL, Yang WL, Zhang H. Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE. Molecular Genetics & Genomics 2021;296(4):1017-1026. IF3.1 [7]
  22. Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari NS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Ostrowski SR, Condino-Neto A, Prando C, Bonradenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S; HGID Lab; COVID Clinicians; COVID-STORM Clinicians; NIAID Immune Response to COVID Group; NH-COVAIR Study Group; Danish CHGE; Danish Blood Donor Study; St. James's Hospital; SARS CoV2 Interest group; French COVID Cohort Study Group; Imagine COVID-Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank Investigators; COVID Human Genetic Effort; CONSTANCES cohort; 3C-Dijon Study; Cerba Health-Care; Etablissement du Sang study group, Anderson MS, Boisson B, Béziat V, Zhang SY, Vandreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Duval X, Mentré F, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova JL. Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths. Science Immunology 2021;6(62):eabl4340. IF24.8 [345]
  23. Pilania RK, Rawat A, Vignesh P, Guleria S, Jindal AK, Das G, Suri D, Gupta A, Gupta K, Chan KW, Lau YL, Imai K, Singh S. Liver abscess in chronic granulomatous dsease-two decades of experience from a tertiary care centre in North-West India. Journal of Clinical Immunology 2021;41(3):552-564. IF9.1
  24. Song Q, Lei Y, Shao L, Li W, Kong Q, Lin Z, Qin X, Wei W, Hou F, Li J, Guo X, Mao Y, Cao Y, Liu Z, Zheng L, Liang R, Jiang Y, Liu Y, Zhang L, Yang J, Lau YL, Zhang Y, Ban B, Wang YF, Yang W. Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus. Rheumatology (Oxford) 2021;60(9):4407-4417. IF5.5 [14]
  25. Wang YF, Zhang Y, Lin Z, Zhang H, Wang TY, Cao Y, Morris DL, Sheng Y, Yin X, Zhong SL, Gu X, Lei Y, He J, Wu Q, Shen JJ, Yang J, Lam TH, Lin JH, Mai ZM, Guo M, Tang Y, Chen Y, Song Q, Ban B, Mok CC, Cui Y, Lu L, Shen N, Sham PC, Lau CS, Smith DK, Vyse TJ, Zhang X, Lau YL, Yang W. Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups. Nature Communications 2021;12(1):772. IF16.6 [116]
  26. Lai SHY, Duque JSR, Chung BH, Chung TW, Leung D, Ho RS, Lee R, Poon RWS, Chua GT, Cheong KN, Chui MMC, Lee M, Tam S, Him AHC, Cheng KF, Ho WW, Yuen KY, Lee P, Lau YL. Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment. International Journal of Infectious Diseases 2021; 107:59-61. IF8.4 [11]
  27. Yu MHC, Chan MCY, Chung CCY, Li AWT, Yip CYW, Mak CCY, Chau JFT, Lee M, Fung JLF, Tsang MHY, Chan JCK, Wong WHS, Yang J, Chui WCM, Chung PHY, Yang W, Lee SL, Chan GCF, Tam PKH, Lau YL, Tang CSM, Yeung KS, Chung BHY. Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population. PLoS Genetics 2021;17(2):e1009323. IF4.5 [13]
  28. Arkin LM, Moon JJ, Tran JM, Asgari S, O'Farrelly C, Casanova JL, Cowen EW, Mays JW, Singh AM, Drolet BA; COVID Human Genetic Effort. From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio. J Investigative Dermatology 2021;141(12):2791-2796. IF2.42 [22]
  29. Asano T, Boisson B, Onodi F, Matuozzo D, Moncada-Velez M, Maglorius Renkilaraj MRL, Zhang P, Meertens L, Bolze A, Materna M, Korniotis S, Gervais A, Talouarn E, Bigio B, Seeleuthner Y, Bilguvar K, Zhang Y, Neehus AL, Ogishi M, Pelham SJ, Le Voyer T, Rosain J, Philippot Q, Soler-Palacín P, Colobran R, Martin-Nalda A, Rivière JG, Tandjaoui-Lambiotte Y, Chaïbi K, Shahrooei M, Darazam IA, Olyaei NA, Mansouri D, Hatipoğlu N, Palabiyik F, Ozcelik T, Novelli G, Novelli A, Casari G, Aiuti A, Carrera P, Bondesan S, Barzaghi F, Rovere-Querini P, Tresoldi C, Franco JL, Rojas J, Reyes LF, Bustos IG, Arias AA, Morelle G, Christèle K, Troya J, Planas-Serra L, Schlüter A, Gut M, Pujol A, Allende LM, Rodriguez-Gallego C, Flores C, Cabrera-Marante O, Pleguezuelo DE, de Diego RP, Keles S, Aytekin G, Akcan OM, Bryceson YT, Bergman P, Brodin P, Smole D, Smith CIE, Norlin AC, Campbell TM, Covill LE, Hammarström L, Pan-Hammarström Q, Abolhassani H, Mane S, Marr N, Ata M, Al Ali F, Khan T, Spaan AN, Dalgard CL, Bonfanti P, Biondi A, Tubiana S, Burdet C, Nussbaum R, Kahn-Kirby A, Snow AL; COVID Human Genetic Effort; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-; Biobank; NIAID-USUHS COVID Study Group, Bustamante J, Puel A, Boisson-Dupuis S, Zhang SY, Béziat V, Lifton RP, Bastard P, Notarangelo LD, Abel L, Su HC, Jouanguy E, Amara A, Soumelis V, Cobat A, Zhang Q, Casanova JL. X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Science Immunology 2021;6(62):eabl4348. IF24.8 [268]
  30. Zhang Q, Cobat A, Bastard P, Notarangelo LD, Su HC, Abel L, Casanova JL and COVID Human Genetic Effort. Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia/Reply. Journal of Clinical Investigation 2021; 131(15). IF15.9 [12]
  31. Stevelink R, Luykx JJ, Lin BD, Leu C, Lal D, Smith AW, Schijven D, Carpay JA, Rademaker K, Rodrigues Baldez RA, Devinsky O, Braun KPJ, Jansen FE, Smit DJA, Koeleman BPC; International League Against Epilepsy Consortium on Complex Epilepsies; Epi25 Collaborative. Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. Epilepsia 2021;62(7):1518-1527. IF5.6 [7]
  32. McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, Broderick C, Nijman R, Tremoulet AH, Munblit D, Ulloa-Gutierrez R, Carter MJ, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Levin M; BATS Consortium. Treatment of Multisystem Inflammatory Syndrome in Children. New England Journal of Medicine 2021; 385(1):11-22. IF158.5 [297]

 

 

Education

 

As Associate Dean for Education in the mid-1990's, Professor YL Lau assisted Dean SP Chow in the design and implementation of the new MBBS curriculum introducing problem-based learning and system-based modules to integrate pre-clinical disciplines with clinical cases. He further started a Post-graduate Diploma course in Child and Adolescent Health in 2004, together with members of the Department. As Founding President of APSID, he has organized 9 Schools based on case-driven learning for over 400 young doctors and scientists to present their difficult PID cases to international faculty for learning together. [Website: http://paed.hku.hk/APSID/home.html] He firmly believes in authentic and supervised learning experience for students and trainees, emphasing on the meticulous analysis of symptoms and signs, with clinical reasoning and scientific mind. In particular, he wishes to emphasize the humanistic aspect of medical practice with reflective learning and real-time feedback.

 

Books and book chapters

 

 

Clinical Service

 

Professor YL Lau is providing clinical service for children with primary immunodeficiencies, rheumatological, allergic and infectious diseases, and those who need stem cell transplants. He has assembled a team of paediatricians with expertise in immunology, infectious diseases, rheumatology and allergy to work side by side with paediatricians with expertise in oncology and haematology.

 

He is now leading the Immunology & Rheumatology service in both Queen Mary Hospital and the Hong Kong Children’s Hospital.