Dr Jaime S ROSA DUQUE (陸俊文)

BS in Biochemistry(USA), MD(USA), PhD in Pharmacology and Toxicology(USA), LMCHK(USA/HK), DCH(UK), FHKCPaed, FHKAM(Paediatrics), DABPed(USA), FAAP(USA), DABA&I(USA), FACAAI(USA), FAAAAI(USA)

 

Clinical Assistant Professor

Department of Paediatrics and Adolescent Medicine

School for Clinical Medicine, The University of Hong Kong

 

Honorary Specialist

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital

Department of Medicine, Queen Mary Hospital

Department of Paediatrics and Adolescent Medicine, The Duchess of Kent Children's Hospital at Sandy Bay

Department of Paediatrics and Adolescent Medicine, Hong Kong Children’s Hospital

Infectious Disease Centre, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital

Allergy Clinic, Department of Paediatrics and Adolescent Medicine, Yan Chai Hospital

Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital

 

Specialty

Allergy, Immunology and Infectious Diseases

Pharmacology

 

Selected Awards

Paediatric Immunology, Allergy and Infectious Diseases Study Day – Best Paper Award (2018)

Della M Mudd Award (2013)

Doctor of Medicine (MD), graduation with Distinction in Research (2010)

Meyskens Family Medical Research Award (2010)

Nathan Weinstein Memorial Research Award (2008)

American Physiological Society Endocrinology and Metabolism Section Research Recognition Award (2007)

 

Contact

Email:

Tel:

Fax:
Office:

jsrduque@hku.hk
(852) 2255-4482
(852) 2855-1523
Department of Paediatrics & Adolescent Medicine
Room 115, 1/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong

 

Research ID

ORCID ID
HKU Scholars Hub

 

Research

Research interests

Immunopharmacology and pharmacogenomics, with a focus on vaccinology and drug adverse events including drug allergy

 

Vaccinology projects:

  • Cellular immunity underlying measles vaccine failures
  • Inborn error of immunity (primary immunodeficiencies) as a cause of vaccine failures in preventing severe infections due to Streptococcus pneumoniae
  • Coronavirus disease 2019 vaccine effectiveness – epidemiology and immune mechanisms

Drug Adverse Events projects:

  • Immediate hypersensitivity to beta-lactam antibiotics – epidemiology, diagnostics and immune mechanisms, genetic and genomic predisposition
  • Delayed hypersensitivities to anticonvulsants – epidemiology, diagnostics and immune mechanisms, genetic and genomic predisposition
  • Immune mechanisms underlying induction of temporary tolerance to medications or immunotherapies (drug desensitization) in children, particularly to chemotherapeutics and antimicrobials

 

Selected publications (*, denotes corresponding author)

  1. Rosa Duque JS, Mak PQ, Wong JSC, Chan VCM, Chow CK, Chiu WK, Yeung WKY, Lam ICS, Chua GT, Ho MHK, To Kkw,* Ip P,* Kwan MYW.* Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation: an evolving practice. Journal of Hospital Administration, 2020:9(5):26-30.
  2. Leung ASY, Leung NYH, Wai CYY, Xu KJY, Lam MCY, Shum YY, Lee TH, Ho MHK, Rosa Duque JSD, Chua GT, Yau YS, Chan WH, Ho PK, Wong GWK, Leung TF. Characteristics of Chinese fish-allergic patients: findings from double-blind placebo-controlled food challenges. The Journal of Allergy and Clinical Immunology: In Practice, 2020:8(6):2098-2100. PMID: 32061718
  3. Chua GT, Chong PC, Au EY, Cheong KN, Wong WH, Chan EY, Ho MH, Lau YL, Duque JSR.* Skin prick testing a better predictor than blood testing for the diagnosis of peanut allergy in Chinese children. Asian Pacific Journal of Allergy and Immunology, 2019, (in press), doi: 10.12932/AP-110319-0519. PMID: 31310149
  4. Duque JSR,* Cheuk DK, Chong PC, Ip P, Wong WH, Lee PP, Wong IC, Chan GC, Lau YL, Ho MH. Risk factors for drug allergies in Chinese children. Asian Pacific Journal of Allergy and Immunology, 2019, (in press), doi: 10.12932/AP-191018-0417. PMID: 30903997
  5. Rosa Duque JS,* Chong CY, Lau YL, Ho MH. Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics. Asian Pacific Journal of Allergy and Immunology, 2019, 37(3):179-182. PMID: 29981563
  6. Chua GT,* Rosa Duque JS, Chong CY, Lee PP, Lau YL, Ho MH. Paediatric case series of drug reaction with eosinophilia and systemic symptoms (DRESS): 12-year experience at a single referral centre in Hong Kong and the first reported use of infliximab. European Annals of Allergy and Clinical Immunology, 2018, 50(6):273-276. PMID: 29384118
  7. Au EYL,* Rosa Duque JS, Lau CS, Chan E. A patient with anaphylaxis to diphenhydramine without cross-reactivity to loratadine. The Journal of Allergy and Clinical Immunology: In Practice, 2018, 6(3):1061-1063. PMID: 29196087
  8. Rosa JS,* Vuong VB, Haskin O, Liu AY. A novel outpatient desensitization protocol for recombinant human erythropoietin allergy in a pediatric patient. Allergy, Asthma and Clinical Immunology, 2018, 14:8. PMID: 29545827
  9. Rosa JS,* Hernandez JD, Sherr JA, Smith BM, Brown KD, Mahony T, Farhadian B, McGhee SA, Lewis DB, Thienemann M, Frankovich JD. Allergic diseases and immunologic food disorders in pediatric acute-onset neuropsychiatric syndrome. Pediatric Allergy, Immunology, and Pulmonology, 2018:31(3):158-165. PMID: 30283713
  10. Chinthrajah RS, Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC.* Development of a tool predicting severity of allergic reaction during peanut challenge. Annals of Allergy, Asthma and Immunology, 2018:121(1):69-76.e2. PMID: 29709643
  11. Rosa JS, Heydari S, Oliver SR, Flores RL, Pontello AM, Ibardolaza M, Galassetti PR.* Inflammatory cytokine profiles during exercise in obese, diabetic, and healthy children. Journal of Clinical Research in Pediatric Endocrinology, 2011: 3(3):115-121. PMID: 21911323
  12. Rosa JS,* Oliver SR, Flores RL, Ngo J, Milne GL, Galassetti PR. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Pediatric Diabetes, 2011:12(5):464-472. PMID: 21443585
  13. Rosa JS,* Flores RL, Oliver SR, Pontello AM, Zaldivar FP, Galassetti PR. Resting and exercise-induced IL-6 levels in children with type 1 diabetes reflect hyperglycemic profiles during the previous 3 days. Journal of Applied Physiology, 2010:108(2):334-342. PMID: 20007854
  14. Rosa JS,* Mitsuhashi M, Oliver SR, Ogura M, Flores RL, Pontello AM, Galassetti PR. Ex vivo TCR-induced leukocyte gene expression of inflammatory mediators is increased in type 1 diabetic patients but not in overweight children. Diabetes/Metabolism Research and Reviews, 2010:26(1):33-39. PMID: 19943328
  15. Rosa JS,* Schwindt CD, Oliver SR, Leu SY, Flores RL, Galassetti PR. Exercise leukocyte profiles in healthy, type 1 diabetic, overweight, and asthmatic children. Pediatric Exercise Science, 2009:21(1): 19-33. PMID: 19411708
  16. Rosa JS,* Oliver SR, Mitsuhashi M, Flores RL, Pontello AM, Zaldivar FP, Galassetti PR. Altered kinetics of interleukin-6 and other inflammatory mediators during exercise in children with type 1 diabetes. Journal of Investigative Medicine, 2008:56(4): 701-713. PMID: 18382266
  17. Rosa JS,* Flores RL, Oliver SR, Pontello AM, Zaldivar FP, Galassetti PR. Sustained IL-1a, IL-4, IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. Pediatric Diabetes, 2008:9(1):9-16. PMID: 18211631
  18. Rosa JS,* Oliver SR, Flores RL, Graf SC, Pontello AM, Ibardolaza M, Zaldivar FP, Galassetti PR. Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children. Journal of Pediatric Endocrinology and Metabolism, 2007:20(12): 1293-1305. PMID: 18341089

 

 

Education

  • Clinical teaching for medical students, interns and resident trainees at the University of Hong Kong, affiliated hospitals and institutions with honorary appointments
  • Dr Rosa Duque serves as a supervisor for students pursuing master’s, PhD and/or MD degrees who has areas of interest in medical sciences, pharmacology, immunology and allergy, infectious diseases, genetics and genomics, epidemiology and biostatistics

 

Clinical Service

 

Allergy, immunology, infectious diseases, general paediatrics

 

Dr. Rosa Duque’s major clinical focus is on drug allergy.  He is currently leading drug allergy services at multiple clinical sites by honorary appointments.  Assessment tools for complex drug allergy cases include relevant history taking, examinations, skin testing, genetic testing, interpretation of results performed by our Clinical Immunology Laboratory, and drug provocative tests.  Patients can be delabeled and receive the medication freely if the drug allergy is ruled out, or they may benefit from induction of temporary tolerance (drug desensitization) to the medications or immunotherapies.  Dr. Rosa Duque welcomes clinical enquiries, formal consultations and research collaborations from within Hong Kong and worldwide.

 

Dr. Rosa Duque also provides care to patients with other complex allergic disorders, such as food allergies, recurrent anaphylaxis, angioedemas, allergic rhinoconjunctivitis and asthma.

 

Other services include inpatient consultation and outpatient management of inborn error of immunity (primary immunodeficiencies) and rare infectious diseases.

 

He attends regular ward rounds in the paediatric specialty units at Queen Mary Hospital in Hong Kong.