Professor KWOK Sit Yee (郭爕義)

- MBChB(HK), MSc(Medical Genetics)(HK), FRCPCH(UK), FHKAM(Paed), FHKCPaed, DCH(UK)
sityeek@hku.hk
Tel: (852) 3513-6667
Fax: (852) 2855-4089
|
Specialty
Biography
Awards
- Hong Kong HMRF Grant (Health and Medical Research Fund) 2020-2021
- QMH/TYH HA Outstanding Staff Award 2020
- Hospital Authority Corporate Scholarship (Paediatric Cardiovascular Genetic Programme) 2020/21
- Best Paper Award 2012, 2018, 2020, 2024, HK College of Cardiology scientific congress
- Hong Kong Heart Foundation scholarship
Research
- Sudden cardiac death in the young
- Inheritable cardiovascular condition
- Cardiac channelopathy
- Paediatric arrhythmia, device and ablation
Selected publication
Sudden cardiac death / Inheritable cardiovascular conditions:
- Kwok SY, Ho S, Shih FY, Yeung PK, Cheng SSW, Poon WM, Lo IFM, Luk HM. Molecular autopsy in Chinese sudden cardiac death in the young. Am J Med Genet A. 2024 Jul 3:e63797.
- Kwok SY, Kwong AKY, Shi JZ, Shih CFY, Lee M, Mak CCY, Chui M, Tsao S, Chung BHY. Whole genome sequencing in paediatric channelopathy and cardiomyopathy. Front Cardiovasc Med. 2024 Mar 20;11:1335527.
Cardiac channelopathy
- Kwok SY, Liu AP, Chan CY, Lun KS, Fung JL, Mak CC, Chung BH, Yung TC. Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in Paediatrics. Hong Kong Med J. 2018 Dec; 24(6): 561-570.
- Kwok SY, Pflaumer A, et al. Ten-Year Experience in Atenolol Use and Exercise Evaluation in Children with Genetically proven Long QT Sydrome. Journal of Arrhythmia 2017
- Kallas D, Roston TM, Franciosi S, Brett L, Lieve KVV, Kwok SY, et al. Evaluation of age at symptom onset, proband status, and sex as predictors of disease severity in pediatric catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2021 Nov;18(11):1825-1832.
- Baruteau AE…, Kwok SY, … Ackerman MJ, Wilde AA, Schwartz PJ, Probst V. SCN5A mutation in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups. Eur Heart J. 2018 Aug 14; 39(31): 2879-2887
- Bergeman AT …, Kwok SY, … Ackerman MJ, Wilde AAM, van der Werf C. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2023.
- Leung HT, Kwok SY, Kwong KY, Shih FY, Tsao S, Chung BH. Prioritize Variant Reclassification in Pediatric Long QT Syndrome-Time to Revisit. Pediatr Cardiol. 2024 Apr 2.
- Leung HT, Kwok SY, Shih FY, Lun KS, Yung TC, Tsao S. A Tale of Two Conditions: Pediatric Brugada Syndrome Unveiled-Navigating the Challenges of Coexisting Arrhythmia and Fever-Induced ECG Pattern. Ann Noninvasive Electrocardiol. 2025 Jan;30(1):e70009.
- Leung HT, Kwok SY, Lau M, Lee LK, Tsao S. Case Report: The unrelenting journey-successful resolution of catecholaminergic polymorphic ventricular tachycardia (CPVT) through right cardiac sympathetic denervation in a teenager after left cardiac sympathetic denervation. Front Cardiovasc Med. 2024 Dec 13;11:1477359.
Paediatric arrhythmia, device and ablation
- Kwok SY, So HK, Choi KC, Lo AF, Li AM, Sung RY, Nelson EA; Resting Heart Rate in Children and Adolescents: Association with Blood Pressure, Exercise and Obesity; 2013 Apr; Archives of Disease in Childhood, 98(4):287-91.
- Kwok SY, Tse HF. Hybrid cardiac resynchronization with leadless pacemaker and transvenous coronary sinus lead. Europace. 2018 Jun 3.
- Kwok SY, Yam N, Lun KS, Chen RH, Au TW, Yung TC. Abdominal implant of subcutaneous implantable cardioverter-defibrillator in a young child. Europace. 2018 Feb 1.
- Kwok SY, Yung T-C , Ho N-L, Hai J-J, Tsao S, Tse H-F. Missing pouches in high-density mapping of atrial tachyarrhythmia in congenital heart diseases. Journal of Arrhythmia. 2019 Dec;35(6):821–829. doi: 10.1002/joa3.12251.
- Kwok SY, Andrew Mark Davis, Darren Hutchinson, Andreas Pflaumer; Successful ablation of refractory neonatal atrial flutter; HeartRhythm Case Report July 2015 Volume 1, Issue 4, 245–248.
- Chubb H, Bulic A, Mah D, Moore JP, Janousek J, Fumanelli J, Asaki SY, Pflaumer A, Hill AC, Escudero C, Kwok SY, et al. Impact and Modifiers of Ventricular Pacing in Patients With Single Ventricle Circulation. J Am Coll Cardiol. 2022 Aug 30;80(9):902-914.
- Von Alvensleben JC, Dechert B, Bradley DJ, Fish FA, Moore JP, Pilcher TA, Escudero C, Ceresnak SR, Kwok SY, Balaji S, Aziz PF, Papagiannis J, Cortez D, Garnreiter J, Kean A, Schäfer M, Collins KK. Subcutaneous Implantable Cardioverter-Defibrillators in Pediatrics and Congenital Heart Disease: A Pediatric and Congenital Electrophysiology Society Multicenter Review. JACC Clin Electrophysiol. 2020 Dec;6(14):1752-1761.
- Lamba A,…Kwok SY, … Schwartz PJ, Ackerman MJ, Blom NA, Wilde AAM, Sanatani S. An international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2024 Apr 7:S1547-5271(24)02323-3.
- Yee-Ming Li J, Kwok SY, Tsao S, Hoi-Yan Chung C, Hing-Sang Wong W, Cheung YF. Detection of QT interval prolongation using Apple Watch electrocardiogram in children and adolescents with congenital long QT syndrome. Int J Cardiol Heart Vasc. 2023;47:101232.
- N Wei, A Lamba, S Franciosi, I Law, LA Ochoa, CL Johnsrude, Kwok SY, et al. Medical Management of Infants with Supraventricular Tachycardia: Results from a Registry and Review of the Literature. CJC Pediatric and Congenital Heart Disease 2022; 1: 11-22.
- Bergeman AT,… Kwok SY, … Ackerman MJ, Wilde AAM, van der Werf C. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2023 Dec 19;148(25):2029-2037.
- Tan R,… Kwok SY,…Shah M. Dual- Vs Single-Chamber Ventricular Pacing in Isolated Congenital Complete Atrioventricular Block in Infancy. J Am Coll Cardiol EP. 2025, 0 (0) https://doi.org/10.1016/j.jacep.2024.12.025
Paediatric cardiology
- Kwok SY, Yeung S, Li, WY, YF Cheung; Ventricular Mechanics after Repair of Subarterial and Perimembranous Ventricular Septal Defects. European Journal of Clinical Investigation. 2017 (47) Dec: e12852
- Kwok SY, Cheng FW, Lo AF, Leung WK, Yam MC, Li CK; Variants of Cardiomyopathy and Hypertension in Neuroblastoma; 2013 May; J Pediatr Hematol Oncol.
- Shi JZ, Chow PC, Li W, Kwok SY, Wong WH, Cheung YF. Fifty-Five Years Follow-up of 111 Adult Survivors After Biventricular Repair of PAIVS and PS. Pediatr Cardiol. 2018 Dec 11:2041-2
- Yam MC, So HK, Kwok SY, Lo FC, Mok CF, Leung CK, Yip WK, Sung YT. Left ventricular mass of persistent masked hypertension in Hong Kong Chinese adolescents: a 4-year follow-up study. Cardiol Young. 2018 Apr 22:1-7.
- Rahiman S, Kowalski R, Kwok SY, et al. Milrinone Acts as a Vasodilator But Not an Inotrope in Children After Cardiac Surgery – Insights From Wave Intensity Analysis. Crit Care Med 2020; 48:e1071-e1078.
Knowledge Exchange
International speakers:
- Heart Rhythm Society Scientific Congress
- World Congress in Paediatric Cardiology and Cardiac Surgery
- PediRhythm
- CardioRhythm
- Asia Pacific Heart Rhythm Society Scientific Congress
- South China International Congress of Cardiology
- International Cambodian Cardiovascular Conference
Local speakers
- Certificate course for cardiology (The federation of medical societies of HK)
- Hong Kong College of Cardiology Scientific congress
- Advance in Paediatrics, CUHK
- PRCC Nursing training programme
- Hong Kong Society of Paediatric Cardiology
- Hong Kong College of Paediatrician
- RCSEd/CSHK Conjoint Scientific Congress
Journal reviewer
- Journal of Pediatric Cardiology
- Journal of Cardiac Electrophysiology
- Heart Rhythm Journal
- Hong Kong Journal of Paediatrics
- Journal of Hong Kong College of Cardiology
- American Journal of Medical Genetics
- BMC Pediatrics
- America Heart Association
Clinical Service
He serves as the role of a paediatric cardiologist and electrophysiologist. He acts as a leading role in Paediatric arrhythmia and cardiogenetic service with all collaborators. He is now leading a territory-wide project in investigating familial needs with victims suffered from the sudden cardiac death in the Young in Hong Kong. He also participates actively in volunteer paediatric service and training in under-developed areas in the world.