Funded projects:

1. Allogeneic unrelated hematopoietic stem cell transplantation for patients with transfusion-dependent thalassemia.
2. Allogeneic haploidentical hematopoietic stem cell transplantation for patients with transfusion-dependent thalassemia.
3. Cellular therapy for pediatric cancer patients and hematopoietic stem cell transplant recipients.
4. Comparison of killer immunoglobulin-like receptor genotyping and phenotyping for allogeneic hematopoietic stem cell transplantation in Hong Kong
5. Quadruple immunotherapy for pediatric patients with relapsed or refractory neuroblastoma:
6. CD62L depleted donor lymphocyte infusion with T cell depleted haploidentical hematopoietic stem cell transplantation
7. Association between CD62L+ T-cell recovery and graft-versus-host disease after TCRαβ and CD62L depleted haploidentical hematopoietic stem cell transplant in children

Acute myeloid leukemia

• Karlsson L, Cheuk DKL, De Moerloose B, Hasle H, Jahnukainen K, Juul-Dam KL, Kaspers G, Kovalova Z, Lausen B, Nyström UN, Palle J, Pronk CJ, Saks K, Tierens A, Zeller B, Abrahamsson J. Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia. British Journal of Haematology 2023; 201: 757-765.
• Tierens A, Arad-Cohen N, Cheuk DKL, De Moerloose B, Fernandez Navarro JM, Hasle H, Jahnukainen K, Juul-Dam KL, Kaspers G, Kovalova Z, Lausen B, Norén-Nyström U, Palle J, Pasauliene R, Jan Pronk C, Saks K, Zeller B, Abrahamsson J. Mitoxantrone versus liposomal daunorubicin in induction of pediatric AML with risk stratification based on flow cytometry measurement of residual disease. Journal of Clinical Oncology 2024; 42: 2174-2185.
• Zeller B, Arad-Cohen N, Cheuk DKL, De Moerloose B, Navarro JMF, Hasle H, Jahnukainen K, Juul-Dam KL, Kaspers G, Kovalova Z, Jonsson OG, Lausen B, Munthe-Kaas M, Nystrom UN, Palle J, Pasauliene R, Pronk CJ, Saks K, Tierens A, Abrahamsson J. Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 Protocol. Haematologica 2024; 109: 2873-2883.
• Östlund A, Waraky A, Staffas A, Sjögren H, De Moerloose B, Arad-Cohen N, Cheuk DKL, Navarro JMF, Jahnukainen K, Kaspers GJL, Kovalova Z, Pasauliene R, Saks K, Zeller B, Norén-Nyström U, Hasle H, Fogelstrand L, Abrahamsson J, Palmqvist L. Characterization of pediatric acute myeloid leukemia with t(7;12)(q36;p13). Genes Chromosomes Cancer 2024; 63: e70003.

Hematopoietic stem cell transplantation

• Chan WYK, Lee PPW, Lee V, Chan GCF, Leung W, Ha SY, Cheuk DKL. Outcomes of allogeneic transplantation for hemoglobin Bart's hydrops fetalis syndrome in Hong Kong. Pediatric Transplantation 2021; 25: e14037.
• Mak CYK, Cheuk DKL, Lee PPW, Chiang AKS, Ha SY, Liu APY, Chan GCF. Neurological complications in Chinese children undergoing hematopoietic stem cell transplantation. Child's Nervous System 2021; 37: 3753-3767.
• Chan WYK, Ma ALT, Chan EYH, Kan ANC, Ng WF, Lee PPW, Cheuk DKL, Chiang AKS, Leung W, Chan GCF. Epidemiology and outcomes of pediatric transplant-associated thrombotic microangiopathy in Hong Kong. Pediatric Transplantation 2022; 26: e14366.
• Yeung TW, Chan WYK, Wong SCY, Lee PPW, Cheuk DKL, Leung W. High infection rates and risk-adapted prevention strategies in contemporary pediatric allogeneic hematopoietic stem cell transplantation. Pediatric Discovery 2024; e101.

Cellular therapy

• Chan WYK, Chan NCN, So JCC, Lee PPW, Cheuk DKL, Ha SY, Chan GCF, Leung W. Successful haploidentical hematopoietic stem cell transplantation (HSCT) and durable engraftment by repeated donor lymphocyte infusions for a Chinese patient with transfusion-dependent hemoglobin (Hb) Hammersmith and massive splenomegaly. Pediatric Transplantation 2022; 26: e14278.
• Chan WYK, Lee PPW, Cheuk DKL, Yeung EWM, Wong KCW, Li CK, Chan GCF, Leung W. Blinatumomab with donor lymphocyte infusions post haploidentical hematopoietic stem cell transplantation as salvage therapy for relapsed refractory acute lymphoblastic leukemia post chimeric antigen receptor T-cell therapy. Pediatric Blood Cancer 2023; 70: e29852.
• Li Y, Chan WYK, Cheuk DKL, Lee PP, Leung WH. Memory T cell donor lymphocyte infusion as a treatment for viral reactivations after pediatric haploidentical hematopoietic stem cell transplant. Blood 2023; 142 (Supp 1): 3544.
• Cheuk DKL, Lee PPW, Chan WYK, Chan GCF, So CC, Leung WH. Novel CD62L depleted donor lymphocyte infusion with T-cell receptor alpha-beta depleted haploidentical hematopoietic stem cell transplantation in children. Transplant Immunology 2025: 89: 102176.

Currently Dr Cheuk is the leader of pediatric hematopoietic stem cell transplantation, cellular therapy, and acute myeloid leukemia service in Hong Kong Children’s Hospital. He aspires to continuously improve the outcomes of patients through ongoing research in related fields, collaboration with national and international experts, development and introduction of innovative and advanced technologies with the support of the whole Hematology-Oncology team and other multidisciplinary partners.