Professor Alan Kwok-shing Chiang (蔣國誠)
Clinical Associate Professor
- BSc(St. Andrews), MBChB(Manc), PhD(HK), FHKAM, FRCPCH, FRCP(Edin, Glasg, Lond)
chiangak@hku.hk
Tel: (852) 2255-4091
Fax: (852) 2855-1523
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Biography
Specialty
Haematology and Oncology
Awards
Sir Edward Youde Memorial Fellowship 1994-1996
Croucher Foundation Scholarship, 1994-1997
Young Investigators' Award, Hong Kong International Cancer Congress, 1995
Best free paper presentation, HKSI/FIMSA Advanced Course and Conference: From Basic to Applied Immunology, 1998 Dr. KP Stephen Chang Gold Medal, 1998
Li Ka Shing Prize, 1997-1999 for best PhD thesis
Research areas
I am a clinician-scientist practising in the field of paediatric haematology and oncology. My research interest in Epstein-Barr virus (EBV) biology dated back to my PhD studies at the Department of Pathology of The University of Hong Kong where I was delineating the pathogenic role of EBV in an intriguing EBV-associated malignancy affecting the Chinese population, nasal NK/T cell lymphoma (NL). My work on defining the tumour cell characteristics at the DNA, RNA and protein level and the uniform presence of EBV in the tumour cells had contributed to the WHO classification of this malignancy as a distinct clinicopathologic entity and the prototypic NK cell lymphoma. Studies on EBV gene expression and immune evasion of this tumour revealed that EBV latent genes are downregulated into a latency II pattern and the HLA class I pathway is largely maintained in NL but tumour resistance to cytotoxic T cells might be partly mediated by expression of immunomodulatory cytokines such as interleukin 10 in the tumour microenvironment. The research work was extended to the analysis of EBV carriage in normal healthy individuals, which revealed that coinfection of multiple strains of EBV was unexpectedly prevalent whilst particular viral strains characterized by a 30-bp deletion in the LMP gene might be preferentially selected in NL. The Chiang lab focuses on the understanding of host-virus interactions in primary and persistent EBV infection and on the elucidation of pathogenic mechanisms of EBV in lymphoid and epithelial cancers. Research programs include: (i) Role of adaptive and innate immune responses in the control of EBV: longitudinal study of viral loads, humoral and CD8+ T cell responses in primary EBV infection in Chinese children and development of novel assays in polychromatic flow cytometry to dissect such immune responses; (ii) Sequence analysis of EBV strains in EBV infection subjects and EBV-positive malignancies: development of novel assays in characterizing EBV strains to study distribution and inter-change of EBV strains among different body compartments and to discover pathogenic viral strains in malignancies; (iii) Novel therapeutic strategies for EBV-positive lymphoid and epithelial cancers: discovering action of different compounds in inducing lytic cycle of EBV in cancer cells and dissecting mechanistic pathways of viral lytic induction.
Research Publications
A. (Journal papers/Articles; International)
B. (Journal papers/Articles; Regional and Local)
C. (Conference Papers; International and Regional)
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