Professor Yiu-fai Cheung (張耀輝)



Clinical Professor

Bryan Lin Professor in Paediatric Cardiology
Department of
Paediatrics and Adolescent Medicine, LKS Faculty of Medicine,
The University of Hong Kong



Paediatric Cardiology



Sir Patrick Manson Gold Medal (2004)

Faculty Teaching Medal (2007)





(852) 22554090
(852) 25539491
Department of Paediatrics & Adolescent Medicine
Room 318, 3/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong




Research areas


Paediatric cardiology and adult congenital heart disease are the major areas of Professor Cheung's research.  The scope of research encompasses three domains: (i) paediatric and adult congenital heart disease, (ii) acquired heart disease in children, and (iii) vascular function in health and disease in the young.


His research work focuses on the followings:

l Clinical translation and applications of novel echocardiographic imaging technologies
l Cardiac and vascular mechanics in paediatric and adult congenital heart disease, iron overload and chemotherapy toxicity
l Circulating biomarkers in congenital heart disease
l Long-term clinical outcomes of paediatric congenital heart patients
l Kawasaki disease: genetics and vascular health


RGC-funded projects


l Effect of iron-loading on arterial distensibility and endothelial function in patients with beta thalassaemia major
l Impact of iron overload on left ventricular torsion in patients with beta-thalassaemia major
l Right and left ventricular mechanical dyssynchrony in iron loaded patients with beta-thalassaemia major
l Mechanics of ventricular-ventricular interaction in patients after tetralogy of Fallot repair: analysis by three-dimensional speckle tracking echocardiography


Selected publications


Novel echocardiographic imaging technologies

l Yu HK, Yu W, Cheuk DK, Wong SJ, Chan CF, Cheung YF.  New three-dimensional speckle-tracking echocardiography identities global impairment of left ventricular mechanics with a high sensitivity in childhood cancer survivors.  Journal of the American Society of Echocardiography 2013;26:846-852 (IF:4.277; citation:1) 
l Cheung YF.  The role of 3D wall motion tracking in heart failure.  Nature Reviews Cardiology 2012;9:644-657. (IF:10.400; citation:3)
l Li SN, Wong SJ, Cheung YF.  Novel area strain based on three-dimensional wall motion analysis for assessment of global left ventricular performance after repair of tetralogy of Fallot.  Journal of the American Society of Echocardiography 2011;24:819-825. (IF:4.277; citation:14)
l Chow PC, Liang XC, Cheung EW, Lam WW, Cheung YF. New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function. Heart 2008;94:855-859. (IF:5.014; citation:43)


Cardiac and vascular mechanics

l Ho PK, Lai CTM, Wong SJ, Cheung YF.  Three-dimensional mechanical dyssynchrony and myocardial deformation of the left ventricle in patients with tricuspid atresia after Fontan procedure.  Journal of the American Society of Echocardiography 2012;25:393-400.  (IF:4.277; citation:2)
l Cheung YF, Hong WJ, Chan GCF, Wong SJ, Ha SY.  Left ventricular myocardial deformation and mechanical dyssynchrony in children with normal ventricular shortening fraction after anthracycline therapy.  Heart 2010;96:1137-1141. (IF:5.014; citation:25)
l Cheung YF, Chan CF, Ha SY.  Arterial stiffness and endothelial function in patients with beta-thalassaemia major.  Circulation 2002;106;2561-2566. (IF:15.202; citation:76)
l Cheung YF, Taylor MJ, Fisk NM, Redington AN, Gardiner HM.  Fetal origins of reduced arterial distensibility in the donor twin in twin-twin transfusion syndrome.  Lancet 2000;355:1157-1158. (IF:39.060; citation:72)


Kawasaki disease

l Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML; Hong Kong–Shanghai Kawasaki Disease Genetics Consortium, Lau YL, Zhang J, Ma XJ, Liu F, Wu L; Korean Kawasaki Disease Genetics Consortium, Yoo JJ, Hong SJ, Kim KJ , Kim JJ, Park YM, Hong YM, Sohn S, Jang GY, Ha KS, Nam HK, Byeon JH, Yun SW, Han MK, Lee KY, Hwang JY, Rhim JW, Song MS, Lee HD, Kim DS, Lee JM; Taiwan Kawasaki Disease Genetics Consortium, Chang JS, Tsai FJ, Liang CD, Chen MR, Chi H, Chiu NC, Huang FY, Chang LY, Huang LM, Kuo HC, Huang KP, Lee ML, Hwang B, Huang YC, Lee PC; International Kawasaki Disease Genetics Consortium, Odam M, Christiansen FT, Witt C, Goldwater P, Curtis N, Palasanthiran P, Ziegler J, Nissen M, Nourse C, Kuipers IM, Ottenkamp JJ, Geissler J, Biezeveld M, Tacke C, Filippini L, Brogan P, Klein N, Shah V, Dillon M, Booy R, Shingadia D, Bose A, Mukasa T, Tulloh R, Michie C; US Kawasaki Disease Genetics Consortium, Newburger JW, Baker AL, Rowley AH, Shulman ST, Mason W, Takahashi M, Melish ME, Tremoulet AH; Blue Mountains Eye Study, Viswanathan A, Rochtchina E, Attia J, Scott R, Holliday E, Harrap S. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics 2011;43:1241-1246. (IF:35.209; citation:38) 
l Cheung YF, Huang GY, Chen SB, Liu XQ , Xi L, Liang XC, Huang MR, Chen S, Huang LS, Liu XQ, Chan KW, Lau YL.  Inflammatory gene polymorphisms and susceptibility to Kawasaki disease and its arterial sequelae.  Pediatrics 2008;122:608-614. (IF:5.119; citation:32)
l Cheung YF, Ho MHK, Tam SCF, Yung TC.  Increased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease.  Heart 2004;90:1281-1285. (IF:5.014; citation:42)
l Cheung YF, Yung TC, Tam SC, Ho MH, Chau AKT.  Novel and traditional cardiovascular risk factors in children after Kawasaki disease: Implications for premature atherosclerosis.  Journal of the American College of Cardiology 2004;43:120-124. (IF:13.710; citation:75)


Full publication list




At the Faculty level, Professor Cheung is Chairman of the Board of Studies of Master of Medical Sciences programme.  At the Departmental level, he is member of the Education Committee and helps to coordinate undergraduate teachings of medical students.  Externally, he is member of the Examination Committee of Hong Kong College of Paediatricians.  He serves as examiner of the MBBS examinations, MRCPCH clinical examination, and Licensing Examination of the Medical Council of Hong Kong.


Professor YF Cheung is responsible for the paediatric and paediatric cardiology teaching of medical students, paediatric residents, and cardiology fellows.  Learning-oriented teaching, which emphasizes on the need of students and trainees to become active independent learners, is central to his philosophy.  He is co-director of the Certificate Course in Paediatric Cardiology and the Cardiorespiratory Health and Lifestyle Module of the Postgraduate Diploma in Paediatric and Adolescent Health organized by the Department.  He pioneered the use of multimedia tools in the teaching of paediatric cardiology and has authored 2 books, 1 multimedia CDROM, and 8 book chapters.  In recognition of his work in medical education, he was awarded the Faculty Teaching Medal in 2007.


Books and book chapters


Clinical Service


Professor YF Cheung provides specialist clinical service for children and adults with congenital and children with acquired heart diseasesTogether with other paediatric cardiologists at Queen Mary Hospital, they provide diagnostic evaluation, postoperative care, and transcatheter interventions for patients ranging from neonates with critical heart conditions to grown-up congenital heart patients.