Dr Wanling Yang (楊萬嶺)

M. Medicine (China), Ph.D. Pharmacology and Bioinformatics (Minnesota)

 

Associate Professor
Department of
Paediatrics and Adolescent Medicine,

Scientific Staff, Centre for Genomic Sciences,

LKS Faculty of Medicine, The University of Hong Kong

 

Specialty

Genetics, genomics and Bioinformatics

 

Awards

Buccaneer Research Award, Minnesota Medical Foundation (2002)

LM. Nutter Research Award, Dept of Pharmacology, University of Minnesota (2001)

 

Contact

Email:

Tel:

Fax:
Office:

yangwl@hku.hk
(852) 28315077
(852) 28198142
Department of Paediatrics & Adolescent Medicine
Office 5, 1/F, The Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong
 
Yang Lab webpage

 

Research

 

Research areas

 

Genomics is rapidly becoming a driving force of biomedical research and will have a significant impact on personalized medicine and clinical diagnosis. Large amount of data are being generated. Making sense of the data is challenging and they require multidisciplinary approaches from genetics, molecular biology, statistics and bioinformatics. My laboratory is interested in identifying susceptibility genes for systemic lupus erythematosus by in-depth analysis of GWAS data and finding causal mutations for single gene disorders using next generation sequencing. We are also interested in developing tools for a better understanding of genetic and genomic data and to make genotype-phenotype correlations. Thus we welcome collaborations from different fields and students/postdocs from different background to join our lab.

 

RGC-funded projects

 

l Mapping Susceptibility Genes for Systemic Lupus Erythematosus (SLE) through a Genome-Wide Association Study
l Meta-Analysis of two Asian GWAS datasets for identification of novel genetic variants associated with systemic lupus erythematosus
l Identifying susceptibility genes in the human MHC region independently associated with systemic lupus erythematosus (SLE) in Chinese populations
l Identification of coding variants associated with early-onset and familial systemic lupus erythematosus through whole exome sequencing and replication

 

Selected publications

 

Representative Publications (HKU only):

Genetic studies on lupus:

l Yang W, Minghui Zhao, Nattiya Hirankarn, Chak Sing Lau, Chi Chiu Mok, Tak Mao Chan, Raymond W.S. Wong, Ka Wing Lee, Mo Yin Mok, Sik Nin Wong, Yingyos Avihingsanon, Irene Oi Lin NG, Tsz Leung Lee, Marco Hok Kung Ho, Pamela Pui Wah Lee,? Wilfred Hing Sang Wong, Pak Chung Sham, Yu Lung Lau, ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai Human Molecular Genetics18: 2063-2070, 2009 
http://hmg.oxfordjournals.org/cgi/reprint/18/11/2063
l Yang WShen N, Ye DQ, Liu Q, Zhang Y, Qian XX, Hirankarn N, Ying D, Pan HF, Mok CC, Chan TM, Wong RW, Lee KW, Mok MY, Wong SN, Leung AM, Li XP, Avihingsanon Y, Wong CM, Lee TL, Ho MH, Lee PP, Chang YK, Li PH, Li RJ, Zhang L, Wong WH, Ng IO, Lau CS, Sham PC, Lau YL, Asian Lupus Genetics Consortium. Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus. PLoS Genet 6(2): e1000841. doi:10.1371/journal.pgen.1000841, 2010
http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000841
l Chiea Chuen Khor, Sonia Davila, Willemijn B. Breunis, Yi-Ching Lee, Chisato Shimizu, Victoria J. Wright, Rae S.M. Yeung, Dennis E.K. Tan, Kar Seng Sim, Jie Jin Wang, Tien Yin Wong, Junxiong Pang, Paul Mitchell, Rolando Cimaz, Nagib Dahdah, Yiu-Fai Cheung, Guo-Ying Huang, Yang W, In-Sook Park, Jong-Keuk Lee, Jer-Yuarn Wu, Michael Levin, Jane C. Burns, David Burgner, Taco W. Kuijpers, and Martin L Hibberd, on behalf of the Hong Kong-Shanghai, Korean, Taiwan, U.S. and International, Kawasaki Disease Genetics Consortiums, Genome-wide association study in five independent cohorts identifies FCGR2A as a susceptibility factor for Kawasaki disease, Nat Genet. 2011 Nov 13. doi: 10.1038/ng.981.
l Luo X#Yang W#, Ye DQ, Cui H, Zhang Y, Hirankarn N, Qian X, Tang Y, Lau YL, de Vries N, Tak PP, Tsao BP, Shen N, A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus.? PLoS Genet. 2011 Jun;7(6):e1002128. Epub 2011 Jun 30. 
http://www.plosgenetics.org/article/fetchObject.action?
uri=info%3Adoi%2F10.1371%2Fjournal.pgen.1002128&representation=PDF
l Yang J#Yang W#, Hirankarn N, Ye DQ, Zhang Y, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Baum L, Kwan P, Lee TL, Ho MH, Lee PP, Wong WH, Zeng S, Zhang J, Wong CM, Ng IO, Garcia-Barcelo MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL.? ELF1 is associated with systemic lupus erythematosus in Asian populations. Hum Mol Genet.2011Feb 1;20(3):601-7. Epub 2010 Nov 2 
http://www.ncbi.nlm.nih.gov/pubmed/21044949
l #Mao H, #Yang W, Lee PP, Ho MH, Yang J, Zeng S, Chong CY, Lee TL, Tu W, Lau YL. Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease. Genes Immun.2012 Jul;13(5):437-42. doi: 10.1038/gene.2012.8. Epub 2012 Apr 5.
l #Yang W, #Tang H, #Zhang Y, #Tang X, #Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barcelo MM, Cherny SS, Shen N, Tam PK, Sham PC, Ye DQ, Yang S, Zhang X, Lau YL. Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians. Am J Hum Genet. 2013 Jan 10;92(1):41-51. 
http://ac.els-cdn.com/S0002929712006313/1-s2.0-S0002929712006313-main.pdf?_tid=223651de-1c26-11e3-808c-00000aacb35e&acdnat=1379043766_9ca8f15962a0445006a52ee6ad39c4d8
l Zhang J, Zhang Y, Zhang L, Yang J, Ying D, Zeng S, Lee TL, Lau CS, Chan TM, Leung AMH, Mok CC, Wong SN, Lee KW, Ho MHK, Lee PPW, Chung BHY, Chong CY, Wong RWS, Mok MY, Wong WHS, *Lau YL,*Yang W, Three SNPs in chromosome 11q23.3 are independently associated with systemic lupus erythematosus in Asians? Human Molecular Genetics2013, in press 
http://hmg.oxfordjournals.org/content/early/2013/09/02/hmg.ddt424.long

 

Development of tools for analysis of genomic data:

l G. Lin; Z. Wang; L. Wang; Y.L. Lau; Yang W*Identification of Linked Regions using High-Density SNP Genotype Data in Linkage Analysis, Bioinformatics2008; 24(1):86-93 
http://bioinformatics.oxfordjournals.org/cgi/content/full/24/1/86
l Yang W*, Dingge Ying, Yu Lung Lau, In-depth cDNA library sequencing and quantitative gene expression profiling in cancer biomarker discovery  Genomics, Proteomics, and Bioinformatics, 2009, 7(1-2):1-12 http://www.sciencedirect.com/science/journal/16720229
l Zhang L#, Yang W#*, Ying D, Cherny SS, Hildebrandt F, Sham PC, Lau YL. Homozygosity mapping on a single patient - identification of homozygous regions of recent common ancestry by using population data. Hum Mutat.2011 Jan 25.? 32(3):345-53 
http://www.ncbi.nlm.nih.gov/pubmed/21309031
l Zhang L, Zhang J, Yang J, Ying D, Lau YL, *Yang W. PriVar: a toolkit for prioritizing SNVs and indels from next-generation sequencing data. Bioinformatics. 2013 Jan 1;29(1):124-5. 
http://bioinformatics.oxfordjournals.org/content/29/1/124.full.pdf

*: corresponding author; #: equal contribution

 

Full publication list

 

Education

 

Courses:

CCST9025: Genetics and Human Nature

BBMS2003: Human Genetics

 

We welcome Research Postgraduate Students, MBBS students, high school students and others to have attachment programs to gain hands on experience on genomic data analysis in our laboratory correspondin