Professor Wanling Yang (楊萬嶺)

M. Medicine (China), Ph.D. Pharmacology and Bioinformatics (Minnesota)

 

Professor
Department of Paediatrics and Adolescent Medicine,

Scientific Staff, Centre for Genomic Sciences,

School of Clinical Medicine, The University of Hong Kong

 

Specialty

Genetics, genomics and Bioinformatics

 

Contact

Email:

Tel:

Fax:
Office:

 yangwl@hku.hk
(852) 28315077
(852) 28198142
Department of Paediatrics & Adolescent Medicine
Office 5, 1/F, The Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong
 
Yang Lab webpage

 

Publications List

 

  1. Xing, F., Yang W, Liu, B., and Tao H., Effects of pregnancy iodine-deficiency on monoamine neurotransmitters in neonatal mice brain.  J. of Chinese Endemic Diseases 12(4):203-205, 1993. 
  2. Chakrabarti, S., Yang W, Law, P.Y, Loh H.H. The mu opioid receptor down-regulates differently from the delta-opioid receptor: Requirement of a high affinity receptor/G protein complex formation. Molecular Pharmacology 52:105-113, 1997. http://molpharm.aspetjournals.org/content/52/1/105.long (IF: 4.411, citation: 65)
  3. Loh, HH., Liu, H.C., Cavalli, A., Yang W, Chen, Y.F., Wei, L.N. mu  Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality, Molecular Brain Research 54,321-326, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9555078?dopt=Citation (IF: 2.879; citation: 245)
  4. Yang W, Law, P.Y., Guo, X., Loh, H.H. In vivo activation of a mutant mu-opioid receptor by antagonist: Future direction for opiate pain treatment paradigm that lacks undesirable side effects. Proc. Natl. Acad. Sci. USA 100(4), 2117-2121, 2003.
    (IF: 9.737, citation: 13)
    http://www.ncbi.nlm.nih.gov/pubmed/12525693?dopt=Citation (pharmacology)
    See also correction for this paper: Proc. Natl. Acad. Sci. USA 100(4), 2163, 2003. http://www.pnas.org/content/100/4/2163.3.full
  5. Yang W, White B., Spicer EK., Weinstein BL., and Hildebrandt JD., Complex haplotype structure of the human GNAS gene identifies a recombination hot spot centered on a single nucleotide polymorphism widely used in association studies Pharmacogenetics 14:741-747, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15564881?dopt=Citation (genomics) (IF: 3.608; citation: 12)
  6. Yang W, Hildebrandt, J.D. Genomic analysis of G protein gamma subunits in human and mouse – The relationship between conserved gene structure and G proteindimmer formation  Cellular Signaling, 18(2)194-201, 2006 http://www.ncbi.nlm.nih.gov/pubmed/16006100?dopt=Citation (genomics) (IF: 4.304; citation: 9)
  7. Yang W*, Ping Ng, Minghui Zhao, Thomas K.F. Wong, SM Yiu and Yu Lung Lau, Promoter-sharing by CPNE1 and RBM12 that is conserved from fish to human – Indication of functional interaction between the two genes BMC Genomics, 2008, 9:456 http://www.biomedcentral.com/1471-2164/9/456 (genomics) (IF: 4.397; citation: 4)
  8. Yang W*, Zhanyong Wang, Lusheng Wang, Pak-Chung Sham, Peng Huang and Yu-Lung Lau,  Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies European Journal of Human Genetics, 2008,  16:1535-1543 http://www.nature.com/ejhg/journal/v16/n12/abs/ejhg2008116a.html (statistical genetics)
    (IF: 4.319; citation: 5)
  9. Thomas K.F. Wong, T.W. Lam, Yang W. and SM Yiu, Finding Alternative Splicing Patterns with Strong Support from Expressed Sequences on Individual Exons/Introns, (J. Bioinformatics and Computational Biology, 2008,6(5):1021-33) http://jem.rupress.org/cgi/content/full/205/7/1573 (genomics) (IF: NA, citation: 3)
  10. G. Lin; Z. Wang; L. Wang; Y.L. Lau; Yang W*, Identification of Linked Regions using High-Density SNP Genotype Data in Linkage Analysis, Bioinformatics 2008; 24(1):86-93 http://bioinformatics.oxfordjournals.org/cgi/content/full/24/1/86 (statistical genetics)
    (IF: 5.323; citation: 12)
  11. LC Willcocks, PA Lyons, MR Clatworthy, JI  Robinson, Yang W, SA Newland, V Plagnol, N McGovern, A Condliffe, ER Chilvers, D Adu, EC Jolly, R Watts, YL Lau, AW Morgan, G Nash, KGC Smith. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. (J. Experimental  Medicine 2008, 205(7):1573-82, 10.1084/jem.20072413), http://jem.rupress.org/cgi/content/full/205/7/1573 (collaboration) (IF: 13.214; citation: 108)
  12. Ho-On Siu, Yang W., Yu-Lung Lau, and Marta E Alarcon-Riquelme  Association of a Haplotype of IRF5 Gene with SLE in Chinese,  J. Rheumatology, 2008, 35(2):360-362
    http://www.jrheum.org/content/35/2/360.long  (human genetics)
    (IF: 3.258; citation: 22)
  13. Lin P, Li J, Liu Q, Mao F, Qiu R, Hu H, Song Y, Yang Y, Gao G, Yan C, Yang W, Shao C, Gong Y: A Missense Mutation in SLC33A1, which Encodes the Acetyl-CoA Transporter, Causes Autosomal-Dominant Spastic Paraplegia (SPG42). Am. J. Hum. Genet. 2008, 83:752-759, http://www.cell.com/AJHG/retrieve/pii/S0002929708005880 (collaboration)
    (IF: 11.202; citation: 38)
  14. Chung, B.H., S.T. Lam, T.M. Tong, S.Y. Li, K.S. Lun, D.H. Chan, S.F. Fok, J.S. Or, D.K. Smith, Yang W., and Y.L. Lau. 2009. Identification of novel FBN1 and TGFBR2 mutations in 65 probands with Marfan syndrome or Marfan-like phenotypes. Am J Med Genet A. 2009, 149A:1452-1459, http://www3.interscience.wiley.com/cgi-bin/fulltext/122458321/PDFSTART (human genetics) (IF: 2.304; citation: 9)
  15. Yang W*, Dingge Ying, Yu Lung Lau, In-depth cDNA library sequencing and quantitative gene expression profiling in cancer biomarker discovery  Genomics, Proteomics, and Bioinformatics, 2009, 7(1-2):1-12 http://www.sciencedirect.com/science/journal/16720229 (genomics)
     (IF: NA; citation: 3)
  16. Lusheng Wang, Zhanyong Wang and Yang W*, Linked Region Detection Using High-Density SNP Geno-type Data via the Minimum Recombinant Model of Pedigree Haplotype Inference,  BMC Bioinformatics, 2009, 10:216. http://www.biomedcentral.com/1471-2105/10/216 (statistical genetics) (IF: 3.024; citation: 3)
  17. Yang W, Ping Ng , MingHui Zhao , Nattiya Hirankarn , Chak Sing Lau , Chi Chiu Mok , Tak-Mo Chan , Raymond Wong , Ka Wing Lee , Mo Yin Mok , Sik Nin Wong , Yingyos Avihingsanon , Tsz Leung Lee , Marco Ho , Pamela Lee , Hing-Sang Wong, Population differences in SLE susceptibility genes--STAT4 and BLK, but not PXK, are associated with Systemic Lupus Erythematosus in Hong Kong Chinese  Genes & Immunity, 10: 219-226, 2009, http://www.nature.com/gene/journal/v10/n3/pdf/gene20091a.pdf  (human genetics)
    (IF: 3.675; citation: 41)
  18. Yuk Chang, Yang W, Minghui Zhao, Chi Chiu Mok, Tak Mao Chan, Raymond W.S. Wong, Ka Wing Lee, Mo Yin Mok, Sik Nin Wong, Irene Oi Lin NG, Tsz Leung Lee, Marco Hok Kung Ho, Pamela Pui Wah Lee,  Wilfred Hing Sang Wong, Chak Sing Lau, 6Pak Chung Sham, Yu Lung Lau, Association of BANK1 and TNFSF4 with Systemic Lupus Erythematosus in Hong Kong Chinese  Genes and Immunity, 2009, 10:414-420. (human genetics) (IF: 3.675; citation: 43)
  19. Yang W, Minghui Zhao, Nattiya Hirankarn, Chak Sing Lau, Chi Chiu Mok, Tak Mao Chan, Raymond W.S. Wong, Ka Wing Lee, Mo Yin Mok, Sik Nin Wong, Yingyos Avihingsanon, Irene Oi Lin NG, Tsz Leung Lee, Marco Hok Kung Ho, Pamela Pui Wah Lee,  Wilfred Hing Sang Wong, Pak Chung Sham, Yu Lung Lau, ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai Human Molecular Genetics, 18: 2063-2070, 2009 http://hmg.oxfordjournals.org/cgi/reprint/18/11/2063 (human genetics)
    (IF: 7.692; citation: 40)
  20. Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX, Hirankarn N, Ying D, Pan HF, Mok CC, Chan TM, Wong RW, Lee KW, Mok MY, Wong SN, Leung AM, Li XP, Avihingsanon Y, Wong CM, Lee TL, Ho MH, Lee PP, Chang YK, Li PH, Li RJ, Zhang L, Wong WH, Ng IO, Lau CS, Sham PC, Lau YL, Asian Lupus Genetics Consortium. Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus. PLoS Genet 6(2): e1000841. doi:10.1371/journal.pgen.1000841, 2010
    http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000841  (human genetics) (IF: 8.517; citation: 126)
  21. LC. Willcocks, EJ. Carr, HA. Niederer, TF. Rayner, TN. Williams, Yang W, JAG. Scott, BC Urban, N Peshu, TJ. Vyse, YL Lau, PA. Lyons and KGC Smith, A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus, Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7881-5. Epub 2010 Apr 12. (collaboration) (IF: 9.737; citation: 25)
  22. Lee PP, Chen TX, Jiang LP, Chan KW, Yang W, Lee BW, Chiang WC, Chen XY, Fok SFS, Lee TL, Ho MHK, Yang XQ, and Lau YL. Clinical Characteristics and Genotype-phenotype Correlation in 62 Patients with X-linked Agammaglobulinemia. J Clin Immunol, 2010 Jan;30(1):121-31. http://www.springerlink.com/content/p186n551555l2w78/fulltext.pdf  (collaboration) (IF: 3.382; citation: 10)
  23. Niederer HA, Willcocks LC, Rayner TF, Yang W, Lau YL, Williams TN, Scott JA, Urban BC, Peshu N, Dunstan SJ, Hien TT, Phu NH, Padyukov L, Gunnarsson I, Svenungsson E, Savage CO, Watts RA, Lyons PA, Clayton DG, Copy number, linkage disequilibrium and disease association in the FCGR locus., Smith KG.  Hum Mol Genet. 2010 Aug 15;19(16):3282-94. Epub 2010 May 27. (collaboration) (IF: 7.692, citation: 40)
  24. Shen N, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Wu YL, Yu CY, Tang Y, Chen JY, Yang W, Wong M, Kawasaki A, Tsuchiya N, Sumida T, Kawaguchi Y, Howe HS, Mok MY, Bang SY, Liu FL, Chang DM, Takasaki Y, Hashimoto H, Harley JB, Guthridge JM, Grossman JM, Cantor RM, Song YW, Bae SC, Chen S, Hahn BH, Lau YL, Tsao BP., Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15838-43. Epub 2010 Aug 23. (collaboration) (IF: 9.737, citation: 57)
  25. Lin P, Mao F, Liu Q, Yang W, Shao C, Yan C, Gong Y. A novel deletion mutation in GJB1 causes X-linked Charcot-Marie-Tooth disease in a Han Chinese family. Muscle Nerve. 2010 Dec;42(6):922-6. (collaboration) (IF: 2.314; citation:2)
  26. F Yu, MH Chen, L Kuo, P Huang, Yang W., Bayesian hierarchical modeling and selection of differentially expressed genes for the EST data, Biometrics, 2011 Mar;67(1):142-50. (collaboration) (IF: 1.412)
  27. Yang J#, Yang W#, Hirankarn N, Ye DQ, Zhang Y, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Baum L, Kwan P, Lee TL, Ho MH, Lee PP, Wong WH, Zeng S, Zhang J, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL.  ELF1 is associated with systemic lupus erythematosus in Asian populations. Hum Mol Genet. 2011 Feb 1;20(3):601-7. Epub 2010 Nov 2 http://www.ncbi.nlm.nih.gov/pubmed/21044949 (human genetics)
    (IF: 7.692; citation: 17)
  28. Zhang L#, Yang W#*, Ying D, Cherny SS, Hildebrandt F, Sham PC, Lau YL. Homozygosity mapping on a single patient - identification of homozygous regions of recent common ancestry by using population data. Hum Mutat. 2011 Jan 25.  32(3):345-53 http://www.ncbi.nlm.nih.gov/pubmed/21309031 (statistical genetics)
    (IF: 5.213, citation: 4)
  29. Zhang Y, Yang W*, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Lee TL, Ho MH, Lee PP, Wong WH, Yang J, Zhang J, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Tam PK, Sham PC, Lau CS, Lau YL*. Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun. 2011 Apr;12(3):231-4. Epub 2011 Feb 17. http://www.nature.com/gene/journal/v12/n3/full/gene201066a.html  (human genetics)
    (IF: 3.675, citation: 8)
  30. Chiea Chuen Khor, Sonia Davila, Willemijn B. Breunis, Yi-Ching Lee, Chisato Shimizu, Victoria J. Wright, Rae S.M. Yeung, Dennis E.K. Tan, Kar Seng Sim, Jie Jin Wang, Tien Yin Wong, Junxiong Pang, Paul Mitchell, Rolando Cimaz, Nagib Dahdah, Yiu-Fai Cheung, Guo-Ying Huang, Yang W, In-Sook Park, Jong-Keuk Lee, Jer-Yuarn Wu, Michael Levin, Jane C. Burns, David Burgner, Taco W. Kuijpers, and Martin L Hibberd, on behalf of the Hong Kong-Shanghai, Korean, Taiwan, U.S. and International, Kawasaki Disease Genetics Consortiums, Genome-wide association study in five independent cohorts identifies FCGR2A as a susceptibility factor for Kawasaki disease, Nat Genet. 2011 Nov 13. doi: 10.1038/ng.981. [Epub ahead of print], (collaboration)
    (IF: 35.209; citation: 39)
  31. R. Li#, Yang W#, Jing Zhang#, Nattiya Hirankarn, Hai-Feng Pan, Chi Chiu Mok, Tak Mao Chan, Raymond Woon Sing Wong, Mo Yin Mok, 6Ka Wing Lee, Sik Nin Wong, Alexander Moon Ho Leung, Xiang-Pei Li, Yingyos Avihingsanon, Tsz Leung Lee, Marco Hok Kung Ho, Pamela Pui Wah Lee, Wilfred Hing Sang Wong, Chun-Ming Wong, Irene Oi Lin Ng, Jing Yang, Philip H. Li, Yan Zhang, Lu Zhang, Wenxian Li, Larry Baum, Patrick Kwan, Pornpimol Rianthavorn, Thavatchai Deekajorndej, Kanya Suphapeetiporn, Vorasuk Shotelersuk, Maria-Mercè Garcia-Barceló, 6Stacey S. Cherny, Paul Kwong-Hang Tam, Pak Chung Sham, Chak Sing Lau, Nan Shen *Yu Lung Lau, *Dong-Qing Ye, Association of CD247 with systemic lupus erythematosus in Asian Populations, Lupus. 2011 Oct 17. [Epub ahead of print] (human genetics)
    (IF: 2.783; citation: 3)
  32. Luo X#, Yang W#, Ye DQ, Cui H, Zhang Y, Hirankarn N, Qian X, Tang Y, Lau YL, de Vries N, Tak PP, Tsao BP, Shen N.    A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus.  PLoS Genet. 2011 Jun;7(6):e1002128. Epub 2011 Jun 30. (human genetics) (IF: 8.517, citation: 50)
  33. Guo Y, Baum LW, Sham PC, Wong V, Ng PW, Lui CH, Sin NC, Tsoi TH, Tang CS, Kwan JS, Yip BH, Xiao SM, Thomas GN, Lau YL, Yang W, Cherny SS, Kwan P.  Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese. Hum Mol Genet. 2011 Nov 24. [Epub ahead of print] (IF: 7.692, citation 13)
  34. #Mao H, #Yang W, Lee PP, Ho MH, Yang J, Zeng S, Chong CY, Lee TL, Tu W, Lau YL. Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease. Genes Immun. 2012 Apr 5. (IF:3.675, citation: 8)
  35. Zhang J, Zhang Y, Zhang L, Yang J, Ying D, Zeng S, Lee TL, Lau CS, Chan TM, Leung AMH, Mok CC, Wong SN, Lee KW, Ho MHK, Lee PPW, Chung BHY, Chong CY, Wong RWS, Mok MY, Wong WHS, Lau YL,*Yang W, Epistatic interaction between genetic variants in susceptibility gene ETS1 correlates with IL-17 levels in SLE patients Ann Hum Genet. 2013 Apr 24. doi: 10.1111/ahg.12018. [Epub ahead of print] (IF: 2.215, citation = 1)
  36. Li PH, Wong WH, Lee TL, Lau CS, Chan TM, Leung AM, Tong KL, Tse NK, Mok CC, Wong SN, Lee KW, Ho MH, Lee PP, Chong CY, Wong RW, Mok MY, Ying SK, Fung SK, Lai WM, Yang W, Lau YL. Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese. Rheumatology (Oxford). 2013 Feb;52(2):337-45. (IF=4.212, citation = 3)
  37. PriVar: a toolkit for prioritizing SNVs and indels from next-generation sequencing data. Zhang L, Zhang J, Yang J, Ying D, Lau YL, *Yang W. Bioinformatics. 2013 Jan 1;29(1):124-5. (IF=5.323, citation=2)
  38. Wong EH, Cui L, Ng CL, Tang CS, Liu XL, So MT, Yip BH, Cheng G, Zhang R, Tang WK, Yang W, Lau YL, Baum L, Kwan P, Sun LD, Zuo XB, Ren YQ, Yin XY, Miao XP, Liu J, Lui VC, Ngan ES, Yuan ZW, Zhang SW, Xia J, Wang H, Sun XB, Wang R, Chang T, Chan IH, Chung PH, Zhang XJ, Wong KK, Cherny SS, Sham PC, Tam PK, Garcia-Barcelo MM. Genome-wide copy number variation study in anorectal malformations. Hum Mol Genet. 2013 Feb 1;22(3):621-31. (IF:7.692)
  39. Kaiser R, Taylor KE, Deng Y, Zhao J, Li Y, Nititham J, Chang M, Catanese J, Begovich AB, Brown EE, Edberg JC, McGwin G, Alarcón GS, Ramsey-Goldman R, Reveille JD, Vila LM, Petri M, Kimberly RP, Feng X, Sun L, Shen N, Li W, Lu JX, Wakeland EK, Li QZ, Yang W, Lau YL, Liu FL, Chang DM, Yu CY, Song YW, Tsao BP, Criswell LA; Hwee Siew Howe and the Tan Tock Seng Hospital Systemic Lupus Erythematosus Study Group. Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians. Arthritis Rheum. 2013 Jan;65(1):211-5. (IF=7.477, citation=1)
  40. #Yang W, #Tang H, #Zhang Y, #Tang X, #Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Shen N, Tam PK, Sham PC, Ye DQ, Yang S, Zhang X, Lau YL. Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians. Am J Hum Genet. 2013 Jan 10;92(1):41-51. (IF=11.202, citation=11)
  41. Li MX, Kwan JS, Bao SY, Yang W, Ho SL, Song YQ, Sham PC. Predicting mendelian disease-causing non-synonymous single nucleotide variants in exome sequencing studies. PLoS Genet. 2013 Jan;9(1):e1003143. (IF=8.517; citation=7)
  42. An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4, Zhao H, Yang W, Qiu R, Li J, Xin Q, Wang X, Feng Y, Shan S, Liu Y, Gong Y, Liu Q.  Genes and Immunity 2012, 13 (7) , pp. 536-542 (IF=3.675; citation=4)
  43. Zhang J, Zhang Y, Zhang L, Yang J, Ying D, Zeng S, Lee TL, Lau CS, Chan TM, Leung AMH, Mok CC, Wong SN, Lee KW, Ho MHK, Lee PPW, Chung BHY, Chong CY, Wong RWS, Mok MY, Wong WHS, *Lau YL,*Yang W, Three SNPs in chromosome 11q23.3 are independently associated with systemic lupus erythematosus in Asians  Human Molecular Genetics. (IF: 7.692)
  44. Lee PPW, Mao H, Yang W, Chan KW, Ho MHK, Lee TL, Chan JFW, Woo PCY, Tu W, and  Lau YL, Penicillium marneffei infection and impaired interferon-gamma immunity in humans with autosomal dominant gain-of-phosphorylation STAT1 mutations, Journal of Allergy and Clinical Immunology, in press (IF:12.047,  citation=1)