Dr Anthony Pak-yin LIU (廖栢賢)

MBBS (Hons.), MRCPCH, MMedSc (HK), FHKAM(Paed), FHKCPaed

 

Clinical Assistant Professor

Department of Paediatrics and Adolescent Medicine,

LKS Faculty of Medicine, The University of Hong Kong

 

Contact

Email:

Tel:

Fax:
Office:

apyliu@hku.hk
(852) 2255-4482
(852) 2855-1523
Department of Paediatrics & Adolescent Medicine
Room 115, 1/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong

 

Research ID

ORCid: https://orcid.org/0000-0002-4780-0289

 

Research

 

Research interest

 

Paediatric haematology and oncology with special interest in neuro-oncology and cancer in young children

 

Grants

 

l Principal investigator: Genome-wide DNA-methylation profiling as frontline diagnostic test for central nervous system embryonal tumors in children. Health and Medical Research Fund 2018​.
l Principal investigator: Copy-number variations in Chinese patients with conotruncal defects. Small Project Funding
l Principal investigator: Language and communication in genetic counseling for Sudden Arrhythmia Death Syndromes (SADS) in Hong Kong: An exploratory study. Small Project Funding
l Co-investigator: Copy-number variations in Chinese patients with conotruncal defects - a pilot study of 100 patients. Hong Kong Children’s Heart Foundation.
l Co-investigator: Stopping SADS-stories from Happening – Genetic Diagnosis of SADS (Sudden Arrhythmia Death Syndromes). Hong Kong Children's Heart Foundation.
l Sub-investigator: Immunogenicity and safety study of GlaxoSmithKline Biologicals' HPV-16/18 L1 AS04 vaccine and Merck's Gardasil® vaccine when administered according to alternative 2-dose schedules in 9-14 year old females.

 

Selected publications

 

Pediatric Neuro-Oncology
l Liu A.P.Y., Hastings, C., Wu S. et al. 2018. Treatment burden and long-term health deficits of patients with low-grade glioma or glioneuronal tumors diagnosed during the first year of life. Cancer (in press)
l Liu A.P.Y., Harreld J.H., Jacola J.M. et al. 2018. Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis. Acta Neuropathol Commun, 6:101
l Kumar R., Liu A.P.Y. (co-first author), Orr B.A., Northcott P.A., Robinson G.W. 2018. Advances in classification of pediatric brain tumors through DNA methylation profiling: from research tool to frontline diagnostic. Cancer (Epub)
l Liu A.P.Y., Shing M.M., Yuen H.L., Li C.H., Ling S.C., Luk C.W., Ha S.Y., Li C.K., Chan G.C.F. 2015. Central nervous system tumors in Chinese children under the age of three: a population study. J Pediatr Hematol Oncol, 37(2): 94-103
l Liu A.P.Y., Shing M.M., Yuen H.L., Li C.H., Ling S.C., Luk C.W., Ha S.Y., Li C.K., Kwong D.L., Chan G.C.F. 2013. Timing of adjuvant radiotherapy and treatment outcome in childhood ependymoma. Pediatr Blood Cancer, 61(4): 606-611
   
Pediatric Hematology/Oncology
l Liu A.P.Y., Ip J.J.K., Leung A.W.K. et al. (2018). Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong. Pediatr Blood Cancer (in press)
l Liu A.P.Y., Lee P.P.W., Kwok J.S.Y. et al. (2018). Selective T cell-depleted haploidentical hematopoietic stem cell transplantation for relapsed/refractory neuroblastoma. Pediatr Transplant (Epub)
l Liu A.P.Y., Leung A.W.K., Cheuk D.K.L. et al. (2018). Gemtuzumab Ozogamicin Containing Chemotherapy for Relapsed or Refractory Acute Myeloid Leukemia (AML) in Children. 2017. J Pediatr Hematol Oncol, 40(2):163-8
l Liu A.P.Y., Kwok J.S.Y., Chiang A.K.S. et al. (2017). Donor Lymphocyte Infusion Reversed Graft Rejection in Matched-Unrelated Donor Hematopoietic Stem Cell Transplantation for a Child with Thalassemia. Annals of Hematology, 96(7): 1205-6
l Liu A.P.Y., Cheuk K.L., Lee A.H.Y. et al. (2016). Cyclosporin A for Persistent or Chronic Immune Thrombocytopenia in Children. Ann Hematol, 95(11): 1881-6
l Liu A.P.Y., Leung R.Y.Y., Cheuk K.L. et al. (2016). Remission with Donor Lymphocyte Infusion in a Child with Marrow Relapse after Haploidentical Stem Cell Transplantation for Relapsed Stage 4 Neuroblastoma. Pediatr Blood Cancer, 63(8):1477-9
l Liu A.P.Y., Wong K.N., See Q.W.S. et al. (2016). 11C-Acetate Positron Emission Tomography for Detection of Occult Metastatic Recurrence in Hepatoblastoma. J Pediatr Hematol Oncol, 38(4):317-20
l Liu A.P.Y., Lee V., Li C.K. et al. (2016). Refractory acute lymphoblastic leukemia in Chinese children: bridging to stem cell transplantation with clofarabine, cyclophosphamide and etoposide. Ann Hematol, 95(3): 501-7
   
HPV vaccination
l Leung T.F., Liu A.P.Y. (co-first author), Lim F.S. et al. (2018).Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and 4vHPV vaccine administered according to two- or three-dose schedules in girls aged 9-14 years: results to month 36 from a randomized trial. Vaccine. 36(1): 98-106
l Liu A.P.Y., Ho. F.K.W., Chan L.K.L. et al. (2018).Chinese medical students’ knowledge, attitude, and practice towards Human papillomavirus (HPV) vaccination and their intention to recommend the vaccine. Journal of Paediatrics and Child Health. 54: 302-10
   
Clinical Genetics
l Liu A.P.Y., Chow P.C., Lee P.P.W. et al. (2014). Under-recognition of 22q11.2 deletion in adult Chinese patients with conotruncal anomalies: implications in transitional care. Eur J Med Genet, 57(6): 306-11
l Liu A.P.Y., Tang W.F., Lau E.T. et al. (2013). Expanded Prader–Willi syndrome due to chromosome 15q11.2–14 deletion: Report and a review of literature. Am J Med Genet Part A, 161A(6): 1309-18

 

Education 

 

l Accredited tutor in Problem-Based Learning Programme
l Tutor, Clinical Skills Sessions; MBBS Clinical Interpersonal Skills Workshop; Paediatric Clerkship
l Examiner, MBBS examination

 

Clinical Service

 

General paediatrics, paediatric haematology/oncology, genetic counselling