Dr Pik-to Cheung (張璧濤)

MBBS(HK), MRCP(UK), FHKAM(Paediatrics), FRCP(Edinburgh), FHKCPaed


Clinical Associate Professor
Department of
Paediatrics and Adolescent Medicine, LKS Faculty of Medicine,
The University of Hong Kong



Paediatric Endocrinology








(852) 22554090
(852) 28551523
Department of Paediatrics & Adolescent Medicine
Room 318, 3/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong




Research interests


l Neuroprotection against neonatal brain injuries
l Neurodegeneration of motor neurons secondary to mutant androgen receptor with polyglutamine expansion
l IGF-I n human fetal and postnatal growth and neural protection
l Molecular genetics of paediatric disorders


Current projects


l Neonatal brain injuries and neuroprotection Main fields: Bilirubin toxicity and hypoxic ischaemic encephalopathy
  Studying the protective role of IGF-I in neural
  Studying the cellular and molecular mechanisms of p75 neurotrophic receptor mediated apoptosis in HIE
  Studying the regulation of interleukin-6 by bilirubin - promotor-reporter gene construct
  Studying the molecular mechanisms of bilirubin-mediated cell death - focusing on mitochondrial dysfunction and apoptosis in bilirubin induced apoptosis
  Evaluating the protective/therapeutic effects of various treatment for neonatal brain injuries - caspase inhibitors; IGF-I; neurotrophins; traditional Chinese medicine
l Neurodegeneration mouse model Using transgenic mice and in vitro culture models to study the mechanisms of neurodegeneration in a human hereditary neurodegenerative disorder of motor neuron, spinal and bulbal muscular atrophy, caused by trinucleotide CAG repeat expansion in the androgen receptor gene
l Molecular genetics of endocrine disorders, neurodegenerative and general paediatric disorders


Selected publications



Full publication list





Books and book chapters


Clinical Service