Dr Jaime S Rosa Duque (陸俊文)

MD(US), PhD(US), LMCHK(US/HK), FHKAM(Paediatrics)(HK), DCH(UK), FAAP(US), FACAAI(US), FAAAAI(US), Specialist in Paediatric Immunology, Allergy and Infectious Diseases(HK)

 

 

Clinical Assistant Professor

Department of Paediatrics and Adolescent Medicine
The University of Hong Kong

 

Honorary Distinguished Professor of Immunology and Rheumatology
Guangzhou Women and Children’s Medical Center
Guangzhou Medical University

 

 

Specialties
Immunology, allergy, infectious diseases

 

 

Selected Awards
Paediatric Immunology, Allergy and Infectious Diseases Study Day – Best Paper Award (2018)
Della M Mudd Award (2013)
Doctor of Medicine (MD), graduation with Distinction in Research (2010)
Meyskens Family Medical Research Award (2010)
Nathan Weinstein Memorial Research Award (2008)
American Physiological Society Endocrinology and Metabolism Section Research Recognition Award (2007)

 

 

Contact

Email:

Tel:

Fax:
Office:

 jsrduque@hku.hk
(852) 2255-4091
(852) 2855-1523
Department of Paediatrics & Adolescent Medicine
Room 115, 1/F, New Clinical Building
102 Pokfulam Road, Queen Mary Hospital, Hong Kong

 

 

Research ID

ORCID ID
HKU Scholars Hub

 

 

Research

Research interests

Immunology, with focus on genomics, cellular mechanisms, clinical outcomes and epidemiology of inborn errors of immunity (primary immunodeficiencies), inflammatory bowel disease (IBD), immune-mediated drug allergy and immune responses to vaccination

 

Inborn errors of immunity (basic and translational science, clinical studies)

  • An international network of immunologists whose patients have suspected inborn errors of immunity are referred to our Asian Pacific Society for Immunodeficiency Centre of Excellence at the University of Hong Kong for confirmatory diagnosis, clinical correlation, family screening, in-depth laboratory assays to understand the fundamental immunogenomic alterations at the molecular and cellular levels, with eventual gene discovery and identification of potential immunotherapeutic targets

  • Data science using registry across continents for understanding long-term complications from inborn errors of immunity, clinical management outcomes and recruitment for novel treatments

  • Immune mechanisms underlying monogenic inflammatory bowel disease and responses to novel therapeutics

     

Vaccinology (translational science, clinical studies)

  • Identification of the specific immune responses, cell markers and signaling pathways that are diminished after vaccination against SARS-CoV-2 virus and Streptococcus pneumoniae in inborn errors of immunity and immunocompetent hosts as causes of vaccine failures
  • Long-term immunogenicity after SARS-CoV-2 and measles booster vaccination
  • Immunogenicity to other vaccines, such rotavirus and varicella virus
  • Vaccine effectiveness at the population level

 

Immune-mediated drug allergy (clinical studies)

  • Immediate immune-mediated hypersensitivity reactions and perioperative anaphylaxis to neuromuscular blocking agents (muscle relaxants) – diagnostics, clinical management and induction of temporary tolerance to medications or immunotherapies (drug desensitization) in children
  • Delayed drug hypersensitivities to drugs – epidemiology, diagnostics, genetic and genomic predisposition

 

 

Selected publications (*, denotes first authors; #, denotes corresponding author)

  1. Yu MKL, Chan SHS, Cheng S, Leung D, Chan SM, Yan ASK, Wong WHS, Peiris M,# Lau YL,# Rosa Duque JS.# Hesitancy, reactogenicity and immunogenicity of the mRNA and whole-virus inactivated Covid-19 vaccines in pediatric neuromuscular diseases. Hum Vaccin Immunother. 2023 Dec 31;19(1):2206278. doi: 10.1080/21645515.2023.2206278. Epub 2023 May 9. PMID: 37157992; PMCID: PMC10294767.
  2. Sharma M,* Leung D,* Momenilandi M,* Jones LCW,* Pacillo L,* James AE,* Murrell JR,* Delafontaine S,* Maimaris J,* Vaseghi-Shanjani M,* Del Bel KL,* Lu HY,* Chua GT, Di Cesare S, Fornes O, Liu Z, Di Matteo G, Fu MP, Amodio D, Tam IYS, Chan GSW, Sharma AA, Dalmann J, van der Lee R, Blanchard-Rohner G, Lin S, Philippot Q, Richmond PA, Lee JJ, Matthews A, Seear M, Turvey AK, Philips RL, Brown-Whitehorn TF, Gray CJ, Izumi K, Treat JR, Wood KH, Lack J, Khleborodova A, Niemela JE, Yang X, Liang R, Kui L, Wong CSM, Poon GWK, Hoischen A, van der Made CI, Yang J, Chan KW, Rosa Duque JSD, Lee PPW, Ho MHK, Chung BHY, Le HTM, Yang W, Rohani P, Fouladvand A, Rokni-Zadeh H, Changi-Ashtiani M, Miryounesi M, Puel A, Shahrooei M, Finocchi A, Rossi P, Rivalta B, Cifaldi C, Novelli A, Passarelli C, Arasi S, Bullens D, Sauer K, Claeys T, Biggs CM, Morris EC, Rosenzweig SD, O'Shea JJ, Wasserman WW, Bedford HM, van Karnebeek CDM, Palma P, Burns SO,# Meyts I,# Casanova JL,# Lyons JJ,# Parvaneh N,# Nguyen ATV,# Cancrini C,# Heimall J,# Ahmed H,# McKinnon ML,# Lau YL,# Béziat V,# Turvey SE.# Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease. J Exp Med. 2023 May 1;220(5):e20221755. doi: 10.1084/jem.20221755. Epub 2023 Mar 8. PMID: 36884218; PMCID: PMC10037107.
  3. Rosa Duque JS,* Leung D,* Yip KM, Lee DHL, So HK, Wong WHS,# Lau YL.# COVID-19 vaccines versus pediatric hospitalization. Cell Rep Med. 2023 Feb 21;4(2):100936. doi: 10.1016/j.xcrm.2023.100936. Epub 2023 Jan 23. PMID: 36801010; PMCID: PMC9868379.
  4. Mu X,* Cohen CA,* Leung D,* Rosa Duque JS,* Cheng SMS,* Chung Y, Wong HHW, Lee AMT, Li WY, Tam IYS, Lam JHY, Lee DHL, Chan SM, Tsang LCH, Chan KCK, Li JKC, Luk LLH, Chaothai S, Kwan KKH, Chu NC, Mori M, Jeevan T, Kandeil A, Webby RJ, Tu W,# Valkenburg SA,# Peiris M,# Lau YL.# Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents. Signal Transduct Target Ther. 2022 Dec 14;7(1):397. doi: 10.1038/s41392-022-01282-7. PMID: 36517469.
  5. Tso WWY,* Kwan MYW,* Wang YL, Leung LK, Leung D, Chua GT, Ip P, Fong DYT, Wong WHS, Chan SHS, Chan JFW, Peiris M, Lau YL,# Rosa Duque JS.# Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections. Emerg Microbes Infect. 2022 Dec;11(1):1742-1750. doi: 10.1080/22221751.2022.2093135. PMID: 35730665; PMCID: PMC9258055.
  6. Leung D,* Mu X,* Duque JSR,* Cheng SMS,* Wang M, Zhang W, Zhang Y, Tam IYS, Lee TSS, Lam JHY, Chan SM, Cheang CH, Chung Y, Wong HHW, Lee AMT, Li WY, Chaothai S, Tsang LCH, Chua GT, Cheong KN, Au EYL, Kwok JSY, Chan KW, Chong PCY, Lee PPW, Ho MHK, Lee TL, Tu W,# Peiris M,# Lau YL.# Safety and immunogenicity of 3 doses of BNT162b2 and CoronaVac in children and adults with inborn errors of immunity. Front Immunol. 2022 Sep 20;13:982155. doi: 10.3389/fimmu.2022.982155. PMID: 36203563; PMCID: PMC9530261.
  7. Chan KW, Wong CY, Leung D, Yang X, Fok SFS, Mak PHS, Yao L, Ma W, Mao H, Zhao X, Liang W, Singh S, Barbouche MR, He JX, Jiang LP, Liew WK, Le MHT, Muktiarti D, Santos-Ocampo FJ, Djidjik R, Belaid B, Ismail IH, Abdul Latiff AH, Lee WS, Chen TX, Liu J, Jin R, Wang X, Chien YH, Yu HH, Raj D, Raj R, Vaughan J, Urban M, van den Berg S, Eley B, Lee AC, Isa MS, Ang EY, Lee BW, Yeoh AEJ, Shek LP, Quynh Le NN, Nguyen VAT, Phan Nguyen Lien A, Capulong RD, Mallillin JM, Villanueva JCMM, Camonayan KAB, Vera M, Casis-Hao RJ, Lobo RCM, Foronda R, Binas VWE, Boushaki S, Kechout N, Phongsamart G, Wongwaree S, Jiratchaya C, Lao-Araya M, Trakultivakorn M, Suratannon N, Jirapongsananuruk O, Chantveerawong T, Kamchaisatian W, Chan LL, Koh MT, Wong KJ, Fong SM, Thong MK, Latiff ZA, Noh LM, de Silva R, Jouhadi Z, Al-Saad K, Vignesh P, Jindal AK, Rawat A, Gupta A, Suri D, Yang J, Au EY, Kwok JS, Chan SY, Hui WY, Chua GT, Duque JR, Cheong KN, Chong PCY, Ho MHK, Lee TL, Wong WH, Yang W, Lee PP, Tu W, Yang XQ, Lau YL. Targeted gene sanger sequencing should remain the first-tier genetic test for children suspected to have the five common X-linked inborn errors of immunity. Front Immunol. 2022 Jul 8;13:883446. doi: 10.3389/fimmu.2022.883446. PMID: 35874699; PMCID: PMC9304939.
  8. Rosa Duque JS,* Wang X,* Leung D,* Cheng SMS,* Cohen CA,* Mu X, Hachim A, Zhang Y, Chan SM, Chaothai S, Kwan KKH, Chan KCK, Li JKC, Luk LLH, Tsang LCH, Wong WHS, Cheang CH, Hung TK, Lam JHY, Chua GT, Tso WWY, Ip P, Mori M, Kavian N, Leung WH, Valkenburg S,* Peiris M,* Tu W,* Lau YL.* Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents. Nat Commun. 2022 Jun 28;13(1):3700. doi: 10.1038/s41467-022-31485-z. PMID: 35764637; PMCID: PMC9240007.
  9. Saper VE, Ombrello MJ, Tremoulet AH, Montero-Martin G, Prahalad S, Canna S, Shimizu C, Deutsch G, Tan SY, Remmers EF, Monos D, Hahn T, Phadke OK, Cassidy E, Ferguson I, Mallajosyula V, Xu J, Rosa Duque JS, Chua GT, Ghosh D, Szymanski AM, Rubin D, Burns JC, Tian L, Fernandez-Vina MA, Mellins ED, Hollenbach JA; Drug Hypersensitivity Consortium; INCHARGE Consortium. Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles. Ann Rheum Dis. 2022 Mar;81(3):406-415. doi: 10.1136/annrheumdis-2021-220578. PMID: 34789453.
  10. Chiu TL,* Leung D,* Chan KW, Yeung HM, Wong CY, Mao H, He J, Vignesh P, Liang W, Liew WK, Jiang LP, Chen TX, Chen XY, Tao YB, Xu YB, Yu HH, Terblanche A, Lung DC, Li CR, Chen J, Tian M, Eley B, Yang X, Yang J, Chiang WC, Lee BW, Suri D, Rawat A, Gupta A, Singh S, Wong WHS, Chua GT, Duque JSDR, Cheong KN, Chong PC, Ho MH, Lee TL, Yang W, Lee PP,# Lau YL.# Phenomic analysis of chronic granulomatous disease reveals more severe integumentary infections in X-Linked compared with autosomal recessive chronic granulomatous disease. Front Immunol. 2022 Jan 24;12:803763. doi: 10.3389/fimmu.2021.803763. PMID: 35140711; PMCID: PMC8818666.
  11. Rosa Duque JS,* Leung D,* Au EYL, Lau YL. Second dose of COVID-19 vaccination in immediate reactions to the first BNT162b2. Pediatr Allergy Immunol. 2022 Jan;33(1):e13683. doi: 10.1111/pai.13683. PMID: 34669219; PMCID: PMC8646469.
  12. Chua GT, Chong PC, Au EY, Cheong KN, Wong WH, Chan EY, Ho MH, Lau YL, Duque JSR.# Skin prick testing a better predictor than blood testing for the diagnosis of peanut allergy in Chinese children. Asian Pac J Allergy Immunol. 2021 Dec;39(4):241-248. doi: 10.12932/AP-110319-0519. PMID: 31310149.
  13. Wong CH,* Duque JSR,* Wong JSC,* Chan CV, Lam ICS, Fu YM, Cheong KN, Chua GT, Lee PP, Ip P, Ho MHK, Wong ICK, Chan GC, Leung WH, Lee SL, Lee KP, Chiu SC, Wong MSR, Wong MSC, Lau YL,# Kwan MY.# Epidemiology and trends of infective meningitis in neonates and infants less than 3 months of age in Hong Kong. Int J Infect Dis. 2021 Oct;111:288-294. doi: 10.1016/j.ijid.2021.06.025. PMID: 34217874.
  14. Duque JSR, Cheuk DK, Chong PC, Ip P, Wong WH, Lee PP, Wong IC, Chan GC, Lau YL, Ho MH.# Risk factors for drug allergies in Chinese children. Asian Pac J Allergy Immunol. 2020 Dec;38(4):271-278. doi: 10.12932/AP-191018-0417. PMID: 30903997.
  15. Rosa JS,# Kappagoda S, Hsu AP, Davis J, Holland SM, Liu AY. West Nile virus encephalitis in GATA2 deficiency. Allergy Asthma Clin Immunol. 2019 Jan 24;15:5. doi: 10.1186/s13223-019-0321-x. PMID: 30697248; PMCID: PMC6346581.
  16. Rosa JS,# Hernandez JD, Sherr JA, Smith BM, Brown KD, Farhadian B, Mahony T, McGhee SA, Lewis DB, Thienemann M, Frankovich JD. Allergic diseases and immune-mediated food disorders in pediatric acute-onset neuropsychiatric syndrome. Pediatr Allergy Immunol Pulmonol. 2018 Sep 1;31(3):158-165. doi: 10.1089/ped.2018.0888. PMID: 30283713; PMCID: PMC6154445.
  17. Chinthrajah RS,* Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC.# Development of a tool predicting severity of allergic reaction during peanut challenge. Ann Allergy Asthma Immunol. 2018 Jul;121(1):69-76.e2. doi: 10.1016/j.anai.2018.04.020. PMID: 29709643; PMCID: PMC6026554.
  18. Rosa JS,# Flores RL, Oliver SR, Pontello AM, Zaldivar FP, Galassetti PR. Resting and exercise-induced IL-6 levels in children with type 1 diabetes reflect hyperglycemic profiles during the previous 3 days. J Appl Physiol (1985). 2010 Feb;108(2):334-42. doi: 10.1152/japplphysiol.01083.2009. PMID: 20007854; PMCID: PMC2822671.
  19. Rosa JS,# Flores RL, Oliver SR, Pontello AM, Zaldivar FP, Galassetti PR. Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. Pediatr Diabetes. 2008 Feb;9(1):9-16. doi: 10.1111/j.1399-5448.2007.00243.x. PMID: 18211631.
  20. Rosa JS,# Oliver SR, Flores RL, Graf SC, Pontello AM, Lbardolaza M, Zaldivar FP, Galassetti PR. Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children. J Pediatr Endocrinol Metab. 2007 Dec;20(12):1293-305. doi: 10.1515/jpem.2007.20.12.1293. PMID: 18341089.

Full publication list

 

 

 

Education

Dr Rosa Duque serves as a supervisor for students pursuing a Master’s, PhD or MD degrees with areas of interest in human and animal research, medical sciences, immunology, vaccinology, infectious diseases, allergic diseases, genetics and genomics, flow cytometry, cell culture, murine models, epidemiology and biostatistics

Research and clinical training for medical students, interns, resident trainees and postdoctoral graduates at the University of Hong Kong, its affiliated hospitals and Guangzhou Women and Children’s Medical Center of the Guangzhou Medical University

    PhD students

  • Michael Kwan Leung YU (BS from the Hong Kong Polytechnic University; PhD completed at HKU in August 2024)

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    Master’s Degree students

  • Jeffrey Ching Ho CHAN (MBBS in process at HKU; MResMed at HKU in process)
  • Liz Zixuan YANG (BS from Sichuan University; MPhil at HKU in process)
  • Felice Hei Wun PAK (BS from Queen Mary University of London; MPhil at HKU in process)

 

 

Clinical Service

 

Immunology, allergy and infectious diseases; paediatrics