Dr. James Chun-bong Li (李振邦)

BSc. (Hons), M.Phil, Ph.D

 

Assistant Professor
Department of
Paediatrics and Adolescent Medicine, LKS Faculty of Medicine,
The University of Hong Kong

 

Awards

Young Investigator Award, Hong Kong Society for Immunology, 2011

 

Contact

Email:

Tel:

Office:

jamesli@hku.hk

(852) 28199863

Department of Paediatrics & Adolescent Medicine
L2-01, Laboratory Block, Faculty of Medicine Building 21 Sassoon Road, Pokfulam, Hong Kong

 

Research

 

Research areas

 

l Stem cell biology, cell and immunotherapy
l Immune responses to microbes – HIV, mycobacteria, influenza and drug-resistant bacteria
l Cytokine biology
l Molecular signaling of infectious diseases and cancer
l Platform Technology for investigating Bioactive Molecules from Natural Products

  

Selected publications

 

l *Au KY, Pong JC, Ling WL, Li JC*. MiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B. PLoS One. 2016 Jan 15;11(1):e0146770. doi: 10.1371/journal.pone.0146770. eCollection 2016.
l Guo ZL, Yu B, Ning BT, Chan S, Lin QB, Li JC, Huang JD, Chan GC. Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma. J Hematol Oncol. 2015 Aug 19;8:99. doi: 10.1186/s13045-015-0196-3.
l Ho JT, Chan GC, Li JC*. Systemic effects of gut microbiota and its relationship with disease and modulation. BMC Immunol. 2015 Mar 26;16:21. doi: 10.1186/s12865-015-0083-2. Review
l Ling WW, Wang VW, Lau AS. Li JC* A role for nitric oxide in interleukin-17A mediated mycobacterial survival. Immunology. 2013 Nov;140(3):323-34.
l Yim HC, Li JC, Pong JC, Lau AS. A role for c-Myc in regulating anti-mycobacterial responses. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17749-54
l Fang JW, Li JC*, Au KY, Lau AS. Interleukin-17A Modulation of Bacillus Calmétte Guerin-induced Cytokine Responses. Journal of Leukocyte Biology. 2011 Aug;90(2):333-41.
l Or TC, Yang CL, Law AH, Chik SC, Li JC, Lau AS. Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action. Neuropharmacology. 2011 May;60(6):823-31
l Wang VL, Yang CL, Li JC, Lau AS. Differential effect of Radix Paeoniae Rubra on cytokine expression inducible by mycobacterium. Chin Med. 2011 Mar 30;6(1):14.
l Li JC, Au KY, Fang JW, Yim CH, Lau AS. HIV-1 trans-activator protein dysregulates IFN-gamma signaling contributes to the abrogation of autophagy induction. AIDS, 2011 Jan 2; 25(1): 15-25.
l Li JC, Yim HC, Lau AS. The role of HIV-1 Tat regulatory protein in AIDS pathogenesis: its effects on cytokine dysregulation and contribution to opportunistic infection. Editorial Review. AIDS,2010 Jul 17;24(11):1609-23
l Chan LL, Cheung BK, Li JC, Lau AS. A role for STAT3 and cathepsin S in IL-10 downregulation of IFN-g-induced MHC class II molecule on primary human blood macrophages. Journal of Leukocyte Biology, 2010 Aug;88(2):303-11
l Yang CL, Chik SC, Li JC, Cheung BK, Lau AS. Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. J Med Chem. 2009 Nov 12;52(21):6707-15
l Chan MM, Cheung BK, Li JC, Chan LL, Lau AS. A Role for Glycogen Synthase Kinase-3 in Antagonizing Mycobacterial Immune Evasion by Negatively Regulating IL-10 Induction. Journal of Leukocyte Biology. 2009 Aug;86(2):283-91
l Yim HC, Li JC, Lau JS, Lau AS. HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: microbial interactions in HIV infection. AIDS. 2009 Jul 31;23(12):1473-84
l Lee DC, Yang CL, Chik SC, Li JC, Rong JH, Chan GC, Lau AS. Immunomodulatory effect of Panax ginseng on human promonocytic U937 cells. J Transl Med. 2009 May 14;7:34
l Li JC#, Cheng SM#, Lin BS, Lee DC, Liu L, Chen Z, Lau AS. HIV-1 trans-activator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling. Blood. May 21;113(21):5192-201.
l Chan WK, Lau AS, Li JC, Law HK, Lau YL, Chan GC MHC expression kinetics and immunogenicity of mesenchymal stromal cells after short-term IFN-gamma challenge. Exp Hematol. 2008 Nov;36(11):1545-55
l Gray JS, Bae HK, Li JC, Lau AS, Pestka JJ. Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. Toxicol Sci. 2008 Oct;105(2):322-30
l Cheng SM, Xing B, Li JC, Cheung BK, Lau AS. Interferon-gamma regulation of TNFalpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells. Int J Cancer. 2007 Sep 15;121(6):1190-6
l Li JC, Lau AS. A role for mitogen-activated protein kinase and Ets-1 in the induction of interleukin-10 transcription by human immunodeficiency virus-1 Tat. Immunology. 2007 Jul;121(3):337-48
l Cheung BK, Lee DC, Li JC, Lau AS. A Role for Double-stranded RNA-activated Protein Kinase PKR in Mycobacterium-induced Cytokine Expression. J Immunol. 2005 Dec 1;175(11):7218-25
l Li JC, Lee DC, Cheung BK, Lau AS. Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response. FEBS Lett. 2005 Jun 6;579(14):3055-62
l Wong YF, Cheung TH, Poon KY, Wang VW, Li JC, Lo KW, Yim SF, Yu MY, Lahr G, Chung TK. The role of microsatellite instability in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix. Gynecol Oncol. 2003 Jun;89(3):434-9
l Lo KW, Wong YF, Chan MK, Li JC, Poon JS, Wang VW, Zhu SN, Zhang TM, He ZG, Wu QL, Li GD, Tam JS, Kahn T, Lam P, Cheung TH, Chung TK . Prevalence of human papillomavirus in cervical cancer: a multicenter study in China. Int J Cancer 2002. Jul 20;100(3):327-31
l Lo KW, Cheung TH, Chung TK, Wang VW, Poon JS, Li JC, Lam P, Wong YF. Clinical and prognostic significance of human papillomavirus in a Chinese population of cervical cancers. Gynecol Obstet Invest2001; 51:202-207

# Denotes JCBL and SMC contributed equally to this project

* Denotes JCBL is a co-corresponding author of this manuscript

 

Editorship

Section Editor, BMC Immunology

Associate Editor, Frontiers in Pharmacology

 

Patents

Approved US Patent: Novel compound and uses thereof for treating inflammation and modulating immune responses., PI: Allan SY Lau. Co-I: Cindy LH Yang, James CB Li, and Stanley C Chik. US patent #8,377,987

 

US Patent: Use of Cytoplasmic c-Myc for Regulating Immune Responses. PI: Allan SY Lau. Co-I: Howard CH Yim, James CB Li and John CH Pong. Provisional patent Application Serial #61/407,276.

 

 

Students interested in joining our team, please send email to jamesli@hku.hk for further details.