Professor Godfrey Chi-Fung Chan (陳志峰)

DMD (U. East, Phil), MD (U. East, Phil), LMCHK, MSc (U. Birmingham, UK), Dip Palliative Med (U Wales, UK), MRCP (UK), FHKAM, FHKCPaed, FRCP (Edin), FRCPCH (UK), FAAP (USA)

 

Tsao Yen-Chow Endowed Professor in Paediatrics & Adolescent Medicine
Head
Department of Paediatrics & Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
Chief of Service
Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital / HKU-Shenzhen Hospital / Gleneagle Hospital
Director
Molecular Laboratory for Traditional Chinese Medicine
Deputy Director
Stem Cells & Regenerative Medicine Consortium
Chief Commission Service Coordinator (Paediatric Oncology)

Hong Kong Children's Hospital

 

Selected Publications

288 published articles in Indexed Journals; 115 published abstracts; 9 book chapters; one book

 

5 Selected Publications on Mesenchymal Stem Cells 

  1. Yu JL, Deng R, Chung SK, Chan GCF. Epac Activation Regulates Human Mesenchymal Stem Cells Migration and Adhesion. Stem Cells. 2016 Apr;34(4):948-59. doi: 10.1002/stem.2264.
  2. Robles JD, Liu YP, Cao J, Xiang Z, Cai Y, Manio M, Tang EH, Chan GCF. Immunosuppressive mechanisms of human bone marrow derived mesenchymal stromal cells in BALB/c host graft versus host disease murine models. Exp Hematol Oncol. 2015;4:13. doi: 10.1186/s40164-015-0007-0.
  3. Fung MKL, Liang RHS, Chan GCF. Vincristine But Not Imatinib Could Suppress Mesenchymal Niche’s Support to Lymphoid Leukemic Cells. Leukemia Lymphoma 2010; 51(3):515-22.
  4. Tsao HW, Law HKW, Tu WW, Chan GCF, Lau YL. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cell 2010;28(5):939-54.
  5. Chan WK, Lau ASY, Li JCB, Law HKW, Lau YL, Chan GCF. MHC expression kinetics and immunogenicity of mesenchymal stromal cells after short term IFN-g challenge. Exp Hematol 2008 ;36(11):1545-55.

 

5 Selected Publications on Studies for TCM 

  1. Jin X, Ruiz Beguerie J, Sze DM, Chan GCF. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2016 Apr 5;4:CD007731.
  2. Chan GCF, Cheung KW, Sze DMY. The Immunomodulatory and Anticancer Properties of Propolis. Clin Rev Allergy & Immuno 2012;44(3):262-73.
  3. Sze DMY, Chan GCF. Supplements for immune enhancement in hematologic malignancies. Hemtaology (Am Soc Hematol Educ Program) 2009; 313-9.
  4. Chan GCF, Chan WK, Sze DMY. The effects of b-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2(1):25.
  5. Chan WK, Cheung C, Law H, Lau YL, Chan GCF. Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. J Hematol Oncol 2008; 21;1(1):9,1-12.

 

5 Selected Papers on Pediatric Neurogenic Tumors 

  1. Guo ZL, Richardson DR, Kalinowski DS, Kovacevic Z, Tan-Un KC, Chan GCF. The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms. J Hematol Oncol. 2016 Sep 27;9(1):98.
  2. Ning B, Cheuk DK, Chiang AK, Lee PP, Ha SY, Chan GCF. Autologous cord blood transplantation for metastatic neuroblastoma. Pediatr Transplant. 2016;20(2):290-6.
  3. Guo ZL, Yu B, Ning BT, Chan S, Lin QB, Li JC, Huang JD, Chan GCF. Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma. J Hematol Oncol. 2015 Aug 19;8(1):99.
  4. Hong YF, Lai YT, Chan GCF, Sun HZ. Glutathione and MRP transporter mediate a self-propelled disposal of bismuth in human cells. Proc Natl Acad Sci U S A. 2015;112(11):3211-6.
  5. Ma M, Ye JY, Deng RX, Dee CM, Chan GCF. Mesenchymal Stromal Cells May Enhance Metastasis of Neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 Signaling. Cancer Letter 2011 Jul 7.

 

5 Selected Clinical Papers on Pediatric Haematology 

  1. Powell JS, Pasi KJ, Ragni MV, Ozelo MC, Valentino LA, Mahlangu JN, Josephson NC, Perry D, Manco-Johnson MJ, Apte S, Baker RI, Chan GCF, Novitzky N, Wong RS, Krassova S, Allen G, Jiang HY, Innes A, Li S, Cristiano LM, Goyal J, Sommer JM, Dumont JA, Nugent K, Gloria Vigliani, Brennan A, Luk A, Pierce GF. Phase 3 Study of Recombinant Factor IX Fc Fusion Protein in Hemophilia B.N Engl J Med. 2013;369(24):2313-23.
  2. Chan GCF, Ng DMW, Fong DYT, Ha SY, Lau YL. Comparison of subcutaneous infusion needles for transfusion dependent thalassemia patients by intra-personal assessment model. Am J Hematol 2004 ;76(4):398-404.
  3. Cheung YF, Chan GCF, Ha SY. Arterial stiffness and endothelial function in patients with beta thalassemia major. Circulation 2002; 106:2561-2566.
  4. Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X ,  Bouman D,  Li  Y, Mehta P, Kaneko Y, Chan GCF, Chan LC,  Squire J, Scherer SW, Hitzle JK. Fusion of RNA recognition motif-encoding gene, RBM15, to the SAP DNA-binding domain gene, Megakaryoblastic Leukemia-1 (MKL1), in acute megakaryoblastic leukemias with t(1;22)(p13;q13). Nature Genetic 2001; 28(30):220-221.
  5. Chan GCF, Wang WC, Raimondi SC, Behm FG, Krance RA, Chen G, Freiberg A, Ingram L, Butler D, Head DR. Myelodysplastic syndrome in children : Differentiation from acute myeloid leukemia with a low blast count. Leukaemia 1997;11:206-211.